E3 ubiquitin-protein ligase RNF4 (EC 2.3.2.27) (RING finger protein 4) (RING-type E3 ubiquitin transferase RNF4) (Small nuclear ring finger protein) (Protein SNURF)
1_MSTRK 6_ RRGGA 11_ INSRQ 16_ AQKRT 21_ REATS 26_ TPEIS 31_ LEAEP 36_ IELVE 41_ TAGDE 46_ IVDLT 51_ CESLE 56_ PVVVD 61_ LTHND 66_ SVVIV 71_ DERRR 76_ PRRNA 81_ RRLPQ 86_ DHADS 91_ CVVSS 96_ DDEEL 101_ SRDRD 106_ VYVTT 111_ HTPRN 116_ ARDEG 121_ ATGLR 126_ PSGTV 131_ SCPIC 136_ MDGYS 141_ EIVQN 146_ GRLIV 151_ STECG 156_ HVFCS 161_ QCLRD 166_ SLKNA 171_ NTCPT 176_ CRKKI 181_NHKRY
1: E3 ubiquitin-protein ligase which binds polysumoylated chains covalently attached to proteins and mediates 'Lys-6'-, 'Lys-11'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination of those substrates and their subsequent targeting to the proteasome for degradation (PubMed:18408734, PubMed:19307308, PubMed:35013556). Regulates the degradation of several proteins including PML and the transcriptional activator PEA3 (PubMed:18408734, PubMed:19307308, PubMed:20943951). Involved in chromosome alignment and spindle assembly, it regulates the kinetochore CENPH-CENPI-CENPK complex by targeting polysumoylated CENPI to proteasomal degradation (PubMed:20212317). Regulates the cellular responses to hypoxia and heat shock through degradation of respectively EPAS1 and PARP1 (PubMed:19779455, PubMed:20026589). Alternatively, it may also bind DNA/nucleosomes and have a more direct role in the regulation of transcription for instance enhancing basal transcription and steroid receptor-mediated transcriptional activation (PubMed:12885770). Catalyzes ubiquitination of sumoylated PARP1 in response to PARP1 trapping to chromatin, leading to PARP1 removal from chromatin by VCP/p97 (PubMed:35013556)