Tyrosine-protein phosphatase non-receptor type substrate 1 (SHP substrate 1) (SHPS-1) (Brain Ig-like molecule with tyrosine-based activation motifs) (Bit) (CD172 antigen-like family member A) (Inhibitory receptor SHPS-1) (Macrophage fusion receptor) (MyD-1 antigen) (Signal-regulatory protein alpha-1) (Sirp-alpha-1) (Signal-regulatory protein alpha-2) (Sirp-alpha-2) (Signal-regulatory protein alpha-3) (Sirp-alpha-3) (p84) (CD antigen CD172a)
1_MEPAG 6_ PAPGR 11_ LGPLL 16_ CLLLA 21_ ASCAW 26_ SGVAG 31_ EEELQ 36_ VIQPD 41_ KSVLV 46_ AAGET 51_ ATLRC 56_ TATSL 61_ IPVGP 66_ IQWFR 71_ GAGPG 76_ RELIY 81_ NQKEG 86_ HFPRV 91_ TTVSD 96_ LTKRN 101_ NMDFS 106_ IRIGN 111_ ITPAD 116_ AGTYY 121_ CVKFR 126_ KGSPD 131_ DVEFK 136_ SGAGT 141_ ELSVR 146_ AKPSA 151_ PVVSG 156_ PAARA 161_ TPQHT 166_ VSFTC 171_ ESHGF 176_ SPRDI 181_ TLKWF 186_ KNGNE 191_ LSDFQ 196_ TNVDP 201_ VGESV 206_ SYSIH 211_ STAKV 216_ VLTRE 221_ DVHSQ 226_ VICEV 231_ AHVTL 236_ QGDPL 241_ RGTAN 246_ LSETI 251_ RVPPT 256_ LEVTQ 261_ QPVRA 266_ ENQVN 271_ VTCQV 276_ RKFYP 281_ QRLQL 286_ TWLEN 291_ GNVSR 296_ TETAS 301_ TVTEN 306_ KDGTY 311_ NWMSW 316_ LLVNV 321_ SAHRD 326_ DVKLT 331_ CQVEH 336_ DGQPA 341_ VSKSH 346_ DLKVS 351_ AHPKE 356_ QGSNT 361_ AAENT 366_ GSNER 371_ NIYIV 376_ VGVVC 381_ TLLVA 386_ LLMAA 391_ LYLVR 396_ IRQKK 401_ AQGST 406_ SSTRL 411_ HEPEK 416_ NAREI 421_ TQDTN 426_ DITYA 431_ DLNLP 436_ KGKKP 441_ APQAA 446_ EPNNH 451_ TEYAS 456_ IQTSP 461_ QPASE 466_ DTLTY 471_ ADLDM 476_ VHLNR 481_ TPKQP 486_ APKPE 491_ PSFSE 496_YASVQ
1: Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function (By similarity). Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Plays a role in antiviral immunity and limits new world arenavirus infection by decreasing virus internalization (By similarity). Receptor for THBS1 (PubMed:24511121). Interaction with THBS1 stimulates phosphorylation of SIRPA (By similarity). In response to THBS1, involved in ROS signaling in non-phagocytic cells, stimulating NADPH oxidase-derived ROS production (PubMed:24511121)