Cytochrome P450 4F2 (EC 1.14.14.1) (20-hydroxyeicosatetraenoic acid synthase) (20-HETE synthase) (Arachidonic acid omega-hydroxylase) (CYPIVF2) (Cytochrome P450-LTB-omega) (Docosahexaenoic acid omega-hydroxylase) (EC 1.14.14.79) (Leukotriene-B(4) 20-monooxygenase 1) (Leukotriene-B(4) omega-hydroxylase 1) (EC 1.14.14.94) (Phylloquinone omega-hydroxylase CYP4F2) (EC 1.14.14.78)
1_MSQLS 6_ LSWLG 11_ LWPVA 16_ ASPWL 21_ LLLLV 26_ GASWL 31_ LAHVL 36_ AWTYA 41_ FYDNC 46_ RRLRC 51_ FPQPP 56_ RRNWF 61_ WGHQG 66_ MVNPT 71_ EEGMR 76_ VLTQL 81_ VATYP 86_ QGFKV 91_ WMGPI 96_ SPLLS 101_ LCHPD 106_ IIRSV 111_ INASA 116_ AIAPK 121_ DKFFY 126_ SFLEP 131_ WLGDG 136_ LLLSA 141_ GDKWS 146_ RHRRM 151_ LTPAF 156_ HFNIL 161_ KPYMK 166_ IFNES 171_ VNIMH 176_ AKWQL 181_ LASEG 186_ SACLD 191_ MFEHI 196_ SLMTL 201_ DSLQK 206_ CVFSF 211_ DSHCQ 216_ EKPSE 221_ YIAAI 226_ LELSA 231_ LVSKR 236_ HHEIL 241_ LHIDF 246_ LYYLT 251_ PDGQR 256_ FRRAC 261_ RLVHD 266_ FTDAV 271_ IQERR 276_ RTLPS 281_ QGVDD 286_ FLQAK 291_ AKSKT 296_ LDFID 301_ VLLLS 306_ KDEDG 311_ KKLSD 316_ EDIRA 321_ EADTF 326_ MFEGH 331_ DTTAS 336_ GLSWV 341_ LYHLA 346_ KHPEY 351_ QERCR 356_ QEVQE 361_ LLKDR 366_ EPKEI 371_ EWDDL 376_ AHLPF 381_ LTMCM 386_ KESLR 391_ LHPPV 396_ PVISR 401_ HVTQD 406_ IVLPD 411_ GRVIP 416_ KGIIC 421_ LISVF 426_ GTHHN 431_ PAVWP 436_ DPEVY 441_ DPFRF 446_ DPENI 451_ KERSP 456_ LAFIP 461_ FSAGP 466_ RNCIG 471_ QTFAM 476_ AEMKV 481_ VLALT 486_ LLRFR 491_ VLPDH 496_ TEPRR 501_ KPELV 506_ LRAEG 511_GLWLR
1: A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, eicosanoids and vitamins (PubMed:10660572, PubMed:10833273, PubMed:11997390, PubMed:17341693, PubMed:18574070, PubMed:18577768). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes predominantly the oxidation of the terminal carbon (omega-oxidation) of long- and very long-chain fatty acids. Displays high omega-hydroxylase activity toward polyunsaturated fatty acids (PUFAs) (PubMed:18577768). Participates in the conversion of arachidonic acid to omega-hydroxyeicosatetraenoic acid (20-HETE), a signaling molecule acting both as vasoconstrictive and natriuretic with overall effect on arterial blood pressure (PubMed:10660572, PubMed:17341693, PubMed:18574070). Plays a role in the oxidative inactivation of eicosanoids, including both pro-inflammatory and anti-inflammatory mediators such as leukotriene B4 (LTB4), lipoxin A4 (LXA4), and several HETEs (PubMed:10660572, PubMed:10833273, PubMed:17341693, PubMed:18574070, PubMed:18577768, PubMed:8026587, PubMed:9799565). Catalyzes omega-hydroxylation of 3-hydroxy fatty acids (PubMed:18065749). Converts monoepoxides of linoleic acid leukotoxin and isoleukotoxin to omega-hydroxylated metabolites (PubMed:15145985). Contributes to the degradation of very long-chain fatty acids (VLCFAs) by catalyzing successive omega-oxidations and chain shortening (PubMed:16547005, PubMed:18182499). Plays an important role in vitamin metabolism by chain shortening. Catalyzes omega-hydroxylation of the phytyl chain of tocopherols (forms of vitamin E), with preference for gamma-tocopherols over alpha-tocopherols, thus promoting retention of alpha-tocopherols in tissues (PubMed:11997390). Omega-hydroxylates and inactivates phylloquinone (vitamin K1), and menaquinone-4 (MK-4, a form of vitamin K2), both acting as cofactors in blood coagulation (PubMed:19297519, PubMed:24138531)