Gamma-aminobutyric acid receptor subunit epsilon (GABA(A) receptor subunit epsilon)
1_MLSKV 6_ LPVLL 11_ GILLI 16_ LQSRV 21_ EGPQT 26_ ESKNE 31_ ASSRD 36_ VVYGP 41_ QPQPL 46_ ENQLL 51_ SEETK 56_ STETE 61_ TGSRV 66_ GKLPE 71_ ASRIL 76_ NTILS 81_ NYDHK 86_ LRPGI 91_ GEKPT 96_ VVTVE 101_ ISVNS 106_ LGPLS 111_ ILDME 116_ YTIDI 121_ IFSQT 126_ WYDER 131_ LCYND 136_ TFESL 141_ VLNGN 146_ VVSQL 151_ WIPDT 156_ FFRNS 161_ KRTHE 166_ HEITM 171_ PNQMV 176_ RIYKD 181_ GKVLY 186_ TIRMT 191_ IDAGC 196_ SLHML 201_ RFPMD 206_ SHSCP 211_ LSFSS 216_ FSYPE 221_ NEMIY 226_ KWENF 231_ KLEIN 236_ EKNSW 241_ KLFQF 246_ DFTGV 251_ SNKTE 256_ IITTP 261_ VGDFM 266_ VMTIF 271_ FNVSR 276_ RFGYV 281_ AFQNY 286_ VPSSV 291_ TTMLS 296_ WVSFW 301_ IKTES 306_ APART 311_ SLGIT 316_ SVLTM 321_ TTLGT 326_ FSRKN 331_ FPRVS 336_ YITAL 341_ DFYIA 346_ ICFVF 351_ CFCAL 356_ LEFAV 361_ LNFLI 366_ YNQTK 371_ AHASP 376_ KLRHP 381_ RINSR 386_ AHART 391_ RARSR 396_ ACARQ 401_ HQEAF 406_ VCQIV 411_ TTEGS 416_ DGEER 421_ PSCSA 426_ QQPPS 431_ PGSPE 436_ GPRSL 441_ CSKLA 446_ CCEWC 451_ KRFKK 456_ YFCMV 461_ PDCEG 466_ STWQQ 471_ GRLCI 476_ HVYRL 481_ DNYSR 486_ VVFPV 491_ TFFFF 496_ NVLYW 501_LVCLN
1: Epsilon subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:16412217, PubMed:9882711). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interfaces (By similarity). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (By similarity). GABAARs containing epsilon subunits also permit spontaneous chloride channel activity while preserving the structural information required for GABA-gated openings (PubMed:16412217, PubMed:9882711). GABARs containing epsilon subunit may regulate cardiac function (Probable)