Disks large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP-90) (SAP90)
1_MDCLC 6_ IVTTK 11_ KYRYQ 16_ DEDTP 21_ PLEHS 26_ PAHLP 31_ NQANS 36_ PPVIV 41_ NTDTL 46_ EAPGY 51_ ELQVN 56_ GTEGE 61_ MEYEE 66_ ITLER 71_ GNSGL 76_ GFSIA 81_ GGTDN 86_ PHIGD 91_ DPSIF 96_ ITKII 101_ PGGAA 106_ AQDGR 111_ LRVND 116_ SILFV 121_ NEVDV 126_ REVTH 131_ SAAVE 136_ ALKEA 141_ GSIVR 146_ LYVMR 151_ RKPPA 156_ EKVME 161_ IKLIK 166_ GPKGL 171_ GFSIA 176_ GGVGN 181_ QHIPG 186_ DNSIY 191_ VTKII 196_ EGGAA 201_ HKDGR 206_ LQIGD 211_ KILAV 216_ NSVGL 221_ EDVMH 226_ EDAVA 231_ ALKNT 236_ YDVVY 241_ LKVAK 246_ PSNAY 251_ LSDSY 256_ APPDI 261_ TTSYS 266_ QHLDN 271_ EISHS 276_ SYLGT 281_ DYPTA 286_ MTPTS 291_ PRRYS 296_ PVAKD 301_ LLGEE 306_ DIPRE 311_ PRRIV 316_ IHRGS 321_ TGLGF 326_ NIVGG 331_ EDGEG 336_ IFISF 341_ ILAGG 346_ PADLS 351_ GELRK 356_ GDQIL 361_ SVNGV 366_ DLRNA 371_ SHEQA 376_ AIALK 381_ NAGQT 386_ VTIIA 391_ QYKPE 396_ EYSRF 401_ EAKIH 406_ DLREQ 411_ LMNSS 416_ LGSGT 421_ ASLRS 426_ NPKRG 431_ FYIRA 436_ LFDYD 441_ KTKDC 446_ GFLSQ 451_ ALSFR 456_ FGDVL 461_ HVIDA 466_ SDEEW 471_ WQARR 476_ VHSDS 481_ ETDDI 486_ GFIPS 491_ KRRVE 496_ RREWS 501_ RLKAK 506_ DWGSS 511_ SGSQG 516_ REDSV 521_ LSYET 526_ VTQME 531_ VHYAR 536_ PIIIL 541_ GPTKD 546_ RANDD 551_ LLSEF 556_ PDKFG 561_ SCVPH 566_ TTRPK 571_ REYEI 576_ DGRDY 581_ HFVSS 586_ REKME 591_ KDIQA 596_ HKFIE 601_ AGQYN 606_ SHLYG 611_ TSVQS 616_ VREVA 621_ EQGKH 626_ CILDV 631_ SANAV 636_ RRLQA 641_ AHLHP 646_ IAIFI 651_ RPRSL 656_ ENVLE 661_ INKRI 666_ TEEQA 671_ RKAFD 676_ RATKL 681_ EQEFT 686_ ECFSA 691_ IVEGD 696_ SFEEI 701_ YHKVK 706_ RVIED 711_ LSGPY 716_IWVPA
1: Postsynaptic scaffolding protein that plays a critical role in synaptogenesis and synaptic plasticity by providing a platform for the postsynaptic clustering of crucial synaptic proteins. Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B. Also regulates AMPA-type glutamate receptor (AMPAR) immobilization at postsynaptic density keeping the channels in an activated state in the presence of glutamate and preventing synaptic depression (By similarity). Under basal conditions, cooperates with FYN to stabilize palmitoyltransferase ZDHHC5 at the synaptic membrane through FYN-mediated phosphorylation of ZDHHC5 and its subsequent inhibition of association with endocytic proteins (PubMed:26334723)