Phosphatidylinositol 5-phosphate 4-kinase type-2 beta (EC 2.7.1.149) (1-phosphatidylinositol 5-phosphate 4-kinase 2-beta) (Diphosphoinositide kinase 2-beta) (Phosphatidylinositol 5-phosphate 4-kinase type II beta) (PI(5)P 4-kinase type II beta) (PIP4KII-beta) (PtdIns(5)P-4-kinase isoform 2-beta)
1_MSSNC 6_ TSTTA 11_ VAVAP 16_ LSASK 21_ TKTKK 26_ KHFVC 31_ QKVKL 36_ FRASE 41_ PILSV 46_ LMWGV 51_ NHTIN 56_ ELSNV 61_ PVPVM 66_ LMPDD 71_ FKAYS 76_ KIKVD 81_ NHLFN 86_ KENLP 91_ SRFKF 96_ KEYCP 101_ MVFRN 106_ LRERF 111_ GIDDQ 116_ DYQNS 121_ VTRSA 126_ PINSD 131_ SQGRC 136_ GTRFL 141_ TTYDR 146_ RFVIK 151_ TVSSE 156_ DVAEM 161_ HNILK 166_ KYHQF 171_ IVECH 176_ GNTLL 181_ PQFLG 186_ MYRLT 191_ VDGVE 196_ TYMVV 201_ TRNVF 206_ SHRLT 211_ VHRKY 216_ DLKGS 221_ TVARE 226_ ASDKE 231_ KAKDL 236_ PTFKD 241_ NDFLN 246_ EGQKL 251_ HVGEE 256_ SKKNF 261_ LEKLK 266_ RDVEF 271_ LAQLK 276_ IMDYS 281_ LLVGI 286_ HDVDR 291_ AEQEE 296_ MEVEE 301_ RAEDE 306_ ECEND 311_ GVGGN 316_ LLCSY 321_ GTPPD 326_ SPGNL 331_ LSFPR 336_ FFGPG 341_ EFDPS 346_ VDVYA 351_ MKSHE 356_ SSPKK 361_ EVYFM 366_ AIIDI 371_ LTPYD 376_ TKKKA 381_ AHAAK 386_ TVKHG 391_ AGAEI 396_ STVNP 401_ EQYSK 406_ RFNEF 411_MSNIL
1: Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate (PubMed:26774281, PubMed:9038203). Preferentially utilizes GTP, rather than ATP, for PI(5)P phosphorylation and its activity reflects changes in direct proportion to the physiological GTP concentration (PubMed:26774281). Its GTP-sensing activity is critical for metabolic adaptation (PubMed:26774281). PIP4Ks negatively regulate insulin signaling through a catalytic-independent mechanism. They interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin-dependent conversion to PtdIns(3,4,5)P3 (PubMed:31091439)