SRSF protein kinase 2 (EC 2.7.11.1) (SFRS protein kinase 2) (Serine/arginine-rich protein-specific kinase 2) (SR-protein-specific kinase 2) [Cleaved into: SRSF protein kinase 2 N-terminal; SRSF protein kinase 2 C-terminal]
1_MSVNS 6_ EKSSS 11_ SERPE 16_ PQQKA 21_ PLVPP 26_ PPPPP 31_ PPPPP 36_ PLPDP 41_ TPPEP 46_ EEEIL 51_ GSDDE 56_ EQEDP 61_ ADYCK 66_ GGYHP 71_ VKIGD 76_ LFNGR 81_ YHVIR 86_ KLGWG 91_ HFSTV 96_ WLCWD 101_ MQGKR 106_ FVAMK 111_ VVKSA 116_ QHYTE 121_ TALDE 126_ IKLLK 131_ CVRES 136_ DPSDP 141_ NKDMV 146_ VQLID 151_ DFKIS 156_ GMNGI 161_ HVCMV 166_ FEVLG 171_ HHLLK 176_ WIIKS 181_ NYQGL 186_ PVRCV 191_ KSIIR 196_ QVLQG 201_ LDYLH 206_ SKCKI 211_ IHTDI 216_ KPENI 221_ LMCVD 226_ DAYVR 231_ RMAAE 236_ ATEWQ 241_ KAGAP 246_ PPSGS 251_ AVSTA 256_ PQQKP 261_ IGKIS 266_ KNKKK 271_ KLKKK 276_ QKRQA 281_ ELLEK 286_ RLQEI 291_ EELER 296_ EAERK 301_ IIEEN 306_ ITSAA 311_ PSNDQ 316_ DGEYC 321_ PEVKL 326_ KTTGL 331_ EEAAE 336_ AETAK 341_ DNGEA 346_ EDQEE 351_ KEDAE 356_ KENIE 361_ KDEDD 366_ VDQEL 371_ ANIDP 376_ TWIES 381_ PKTNG 386_ HIENG 391_ PFSLE 396_ QQLDD 401_ EDDDE 406_ EDCPN 411_ PEEYN 416_ LDEPN 421_ AESDY 426_ TYSSS 431_ YEQFN 436_ GELPN 441_ GRHKI 446_ PESQF 451_ PEFST 456_ SLFSG 461_ SLEPV 466_ ACGSV 471_ LSEGS 476_ PLTEQ 481_ EESSP 486_ SHDRS 491_ RTVSA 496_ SSTGD 501_ LPKAK 506_ TRAAD 511_ LLVNP 516_ LDPRN 521_ ADKIR 526_ VKIAD 531_ LGNAC 536_ WVHKH 541_ FTEDI 546_ QTRQY 551_ RSIEV 556_ LIGAG 561_ YSTPA 566_ DIWST 571_ ACMAF 576_ ELATG 581_ DYLFE 586_ PHSGE 591_ DYSRD 596_ EDHIA 601_ HIIEL 606_ LGSIP 611_ RHFAL 616_ SGKYS 621_ REFFN 626_ RRGEL 631_ RHITK 636_ LKPWS 641_ LFDVL 646_ VEKYG 651_ WPHED 656_ AAQFT 661_ DFLIP 666_ MLEMV 671_ PEKRA 676_ SAGEC 681_LRHPW
1: Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing (PubMed:18559500, PubMed:21056976, PubMed:9472028). Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression (PubMed:19592491). This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression (PubMed:21205200). Phosphorylates ACIN1, and redistributes it from the nuclear speckles to the nucleoplasm, resulting in cyclin A1 but not cyclin A2 up-regulation (PubMed:18559500). Plays an essential role in spliceosomal B complex formation via the phosphorylation of DDX23/PRP28 (PubMed:18425142). Probably by phosphorylating DDX23, leads to the suppression of incorrect R-loops formed during transcription; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA (PubMed:28076779). Can mediate hepatitis B virus (HBV) core protein phosphorylation (PubMed:12134018). Plays a negative role in the regulation of HBV replication through a mechanism not involving the phosphorylation of the core protein but by reducing the packaging efficiency of the pregenomic RNA (pgRNA) without affecting the formation of the viral core particles (PubMed:16122776)