Claudin-10 (Oligodendrocyte-specific protein-like) (OSP-like)
1_MASTA 6_ SEIIA 11_ FMVSI 16_ SGWVL 21_ VSSTL 26_ PTDYW 31_ KVSTI 36_ DGTVI 41_ TTATY 46_ WANLW 51_ KACVT 56_ DSTGV 61_ SNCKD 66_ FPSML 71_ ALDGY 76_ IQACR 81_ GLMIA 86_ AVSLG 91_ FFGSI 96_ FALFG 101_ MKCTK 106_ VGGSD 111_ KAKAK 116_ IACLA 121_ GIVFI 126_ LSGLC 131_ SMTGC 136_ SLYAN 141_ KITTE 146_ FFDPL 151_ FVEQK 156_ YELGA 161_ ALFIG 166_ WAGAS 171_ LCIIG 176_ GVIFC 181_ FSISD 186_ NNKTP 191_ RYTYN 196_ GATSV 201_ MSSRT 206_ KYHGG 211_ EDFKT 216_ TNPSK 221_QFDKN
1: Forms paracellular channels: polymerizes in tight junction strands with cation- and anion-selective channels through the strands, conveying epithelial permeability in a process known as paracellular tight junction permeability
2: Forms cation-selective paracellular channels. In sweat glands and in the thick ascending limb (TAL) of Henle's loop in kidney, it controls paracellular sodium permeability which is essential for proper sweat production and renal function (PubMed:19383724, PubMed:28686597, PubMed:28771254, PubMed:35650657, PubMed:36008380)
3: Forms anion-selective paracellular channels. In renal proximal tubules, it conveys selective chloride over hydrogencarbonate anion permeability which is required for renal chloride reabsorption and salt homeostasis