Oxidized low-density lipoprotein receptor 1 (Ox-LDL receptor 1) (C-type lectin domain family 8 member A) (Lectin-like oxidized LDL receptor 1) (LOX-1) (Lectin-like oxLDL receptor 1) (hLOX-1) (Lectin-type oxidized LDL receptor 1) [Cleaved into: Oxidized low-density lipoprotein receptor 1, soluble form]
1_MTFDD 6_ LKIQT 11_ VKDQP 16_ DEKSN 21_ GKKAK 26_ GLQFL 31_ YSPWW 36_ CLAAA 41_ TLGVL 46_ CLGLV 51_ VTIMV 56_ LGMQL 61_ SQVSD 66_ LLTQE 71_ QANLT 76_ HQKKK 81_ LEGQI 86_ SARQQ 91_ AEEAS 96_ QESEN 101_ ELKEM 106_ IETLA 111_ RKLNE 116_ KSKEQ 121_ MELHH 126_ QNLNL 131_ QETLK 136_ RVANC 141_ SAPCP 146_ QDWIW 151_ HGENC 156_ YLFSS 161_ GSFNW 166_ EKSQE 171_ KCLSL 176_ DAKLL 181_ KINST 186_ ADLDF 191_ IQQAI 196_ SYSSF 201_ PFWMG 206_ LSRRN 211_ PSYPW 216_ LWEDG 221_ SPLMP 226_ HLFRV 231_ RGAVS 236_ QTYPS 241_ GTCAY 246_ IQRGA 251_ VYAEN 256_ CILAA 261_ FSICQ 266_KKANL
1: Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria
2: (Microbial infection) May serve as a receptor for adhesin A variant 3 (nadA) of N.meningitidis