Solute carrier family 35 member B1 (ATP/ADP exchanger ER) (AXER) (Endoplasmic reticulum ATP/ADP translocase) (UDP-galactose transporter-related protein 1) (UGTrel1)
1_MASSS 6_ SLVPD 11_ RLRLP 16_ LCFLG 21_ VFVCY 26_ FYYGI 31_ LQEKI 36_ TRGKY 41_ GEGAK 46_ QETFT 51_ FALTL 56_ VFIQC 61_ VINAV 66_ FAKIL 71_ IQFFD 76_ TARVD 81_ RTRSW 86_ LYAAC 91_ SISYL 96_ GAMVS 101_ SNSAL 106_ QFVNY 111_ PTQVL 116_ GKSCK 121_ PIPVM 126_ LLGVT 131_ LLKKK 136_ YPLAK 141_ YLCVL 146_ LIVAG 151_ VALFM 156_ YKPKK 161_ VVGIE 166_ EHTVG 171_ YGELL 176_ LLLSL 181_ TLDGL 186_ TGVSQ 191_ DHMRA 196_ HYQTG 201_ SNHMM 206_ LNINL 211_ WSTLL 216_ LGMGI 221_ LFTGE 226_ LWEFL 231_ SFAER 236_ YPAII 241_ YNILL 246_ FGLTS 251_ ALGQS 256_ FIFMT 261_ VVYFG 266_ PLTCS 271_ IITTT 276_ RKFFT 281_ ILASV 286_ ILFAN 291_ PISPM 296_ QWVGT 301_ VLVFL 306_ GLGLD 311_ AKFGK 316_GAKKT
1: ATP:ADP antiporter that catalyzes the exchange of ATP and ADP across the endoplasmic reticulum (ER) membrane. Imports ATP from the cytosol to the ER lumen and exports ADP in the opposite direction (PubMed:30154480, PubMed:35041824). Regulates ER energy metabolism and protein biogenesis. Appears to be part of a calcium-dependent ER to cytosol low energy response axis, where calcium efflux from ER to the cytosol triggers ATP import into the ER lumen to maintain sufficient ATP supply. Provides ATP to ER chaperone HSPA5 that drives protein folding and trafficking in the ER (PubMed:30154480, PubMed:35041824). Can transport dATP, UTP or UDP in exchange for ATP, but the physiological relevance of this process remains to be established (PubMed:30154480, PubMed:35041824)
2: ATP:ADP antiporter
3: ATP:ADP antiporter