Iroquois-class homeodomain protein IRX-5 (Homeodomain protein IRX-2A) (Homeodomain protein IRXB2) (Iroquois homeobox protein 5)
1_MSYPQ 6_ GYLYQ 11_ PSASL 16_ ALYSC 21_ PAYST 26_ SVISG 31_ PRTDE 36_ LGRSS 41_ SGSAF 46_ SPYAG 51_ STAFT 56_ APSPG 61_ YNSHL 66_ QYGAD 71_ PAAAA 76_ AAAFS 81_ SYVGS 86_ PYDHT 91_ PGMAG 96_ SLGYH 101_ PYAAP 106_ LGSYP 111_ YGDPA 116_ YRKNA 121_ TRDAT 126_ ATLKA 131_ WLNEH 136_ RKNPY 141_ PTKGE 146_ KIMLA 151_ IITKM 156_ TLTQV 161_ STWFA 166_ NARRR 171_ LKKEN 176_ KMTWT 181_ PRNRS 186_ EDEEE 191_ EENID 196_ LEKND 201_ EDEPQ 206_ KPEDK 211_ GDPEG 216_ PEAGG 221_ AEQKA 226_ ASGCE 231_ RLQGP 236_ PTPAG 241_ KETEG 246_ SLSDS 251_ DFKEP 256_ PSEGR 261_ LDALQ 266_ GPPRT 271_ GGPSP 276_ AGPAA 281_ ARLAE 286_ DPAPH 291_ YPAGA 296_ PAPGP 301_ HPAAG 306_ EVPPG 311_ PGGPS 316_ VIHSP 321_ PPPPP 326_ PAVLA 331_ KPKLW 336_ SLAEI 341_ ATSSD 346_ KVKDG 351_ GGGNE 356_ GSPCP 361_ PCPGP 366_ IAGQA 371_ LGGSR 376_ ASPAP 381_ APSRS 386_ PSAQC 391_ PFPGG 396_ TVLSR 401_ PLYYT 406_ APFYP 411_ GYTNY 416_ GSFGH 421_ LHGHP 426_ GPGPG 431_ PTTGP 436_ GSHFN 441_ GLNQT 446_ VLNRA 451_ DALAK 456_ DPKML 461_ RSQSQ 466_ LDLCK 471_ DSPYE 476_LKKGM
1: Establishes the cardiac repolarization gradient by its repressive actions on the KCND2 potassium-channel gene. Required for retinal cone bipolar cell differentiation. May regulate contrast adaptation in the retina and control specific aspects of visual function in circuits of the mammalian retina (By similarity). Could be involved in the regulation of both the cell cycle and apoptosis in prostate cancer cells. Involved in craniofacial and gonadal development. Modulates the migration of progenitor cell populations in branchial arches and gonads by repressing CXCL12