Iroquois-class homeodomain protein IRX-6 (Homeodomain protein IRXB3) (Iroquois homeobox protein 6)
1_MSFPH 6_ FGHPY 11_ RGASQ 16_ FLASA 21_ SSSTT 26_ CCEST 31_ QRSVS 36_ DVASG 41_ STPAP 46_ ALCCA 51_ PYDSR 56_ LLGSA 61_ RPELG 66_ AALGI 71_ YGAPY 76_ AAAAA 81_ AQSYP 86_ GYLPY 91_ SPEPP 96_ SLYGA 101_ LNPQY 106_ EFKEA 111_ AGSFT 116_ SSLAQ 121_ PGAYY 126_ PYERT 131_ LGQYQ 136_ YERYG 141_ AVELS 146_ GAGRR 151_ KNATR 156_ ETTST 161_ LKAWL 166_ NEHRK 171_ NPYPT 176_ KGEKI 181_ MLAII 186_ TKMTL 191_ TQVST 196_ WFANA 201_ RRRLK 206_ KENKM 211_ TWAPK 216_ NKGGE 221_ ERKAE 226_ GGEED 231_ SLGCL 236_ TADTK 241_ EVTAS 246_ QEARG 251_ LRLSD 256_ LEDLE 261_ EEEEE 266_ EEEAE 271_ DEEVV 276_ ATAGD 281_ RLTEF 286_ RKGAQ 291_ SLPGP 296_ CAAAR 301_ EGRLE 306_ RRECG 311_ LAAPR 316_ FSFND 321_ PSGSE 326_ EADFL 331_ SAETG 336_ SPRLT 341_ MHYPC 346_ LEKPR 351_ IWSLA 356_ HTATA 361_ SAVEG 366_ APPAR 371_ PRPRS 376_ PECRM 381_ IPGQP 386_ PASAR 391_ RLSVP 396_ RDSAC 401_ DESSC 406_ IPKAF 411_ GNPKF 416_ ALQGL 421_ PLNCA 426_ PCPRR 431_ SEPVV 436_ QCQYP 441_SGAEA
1: Transcription factor. Binds to the iroquois binding site (IBS) motif of target genes to regulate gene expression; functions as a transcriptional activator or repressor. Modulates expression of RCVRN, VSX1, BHLHE22/BHLHB5 and TACR3/Nk3r. Required downstream of retinal bipolar cell specification for the terminal differentiation of type 2, type 3a and possibly type 6 bipolar cells