Iroquois-class homeodomain protein IRX-3 (Homeodomain protein IRXB1) (Iroquois homeobox protein 3)
1_MSFPQ 6_ LGYQY 11_ IRPLY 16_ PSERP 21_ GAAGG 26_ SGGSA 31_ GARGG 36_ LGAGA 41_ SELNA 46_ SGSLS 51_ NVLSS 56_ VYGAP 61_ YAAAA 66_ AAAAA 71_ QGYGA 76_ FLPYA 81_ AELPI 86_ FPQLG 91_ AQYEL 96_ KDSPG 101_ VQHPA 106_ AAAAF 111_ PHPHP 116_ AFYPY 121_ GQYQF 126_ GDPSR 131_ PKNAT 136_ RESTS 141_ TLKAW 146_ LNEHR 151_ KNPYP 156_ TKGEK 161_ IMLAI 166_ ITKMT 171_ LTQVS 176_ TWFAN 181_ ARRRL 186_ KKENK 191_ MTWAP 196_ RSRTD 201_ EEGNA 206_ YGSER 211_ EEEDE 216_ EEDEE 221_ DGKRE 226_ LELEE 231_ EELGG 236_ EEEDT 241_ GGEGL 246_ ADDDE 251_ DEEID 256_ LENLD 261_ GAATE 266_ PELSL 271_ AGAAR 276_ RDGDL 281_ GLGPI 286_ SDSKN 291_ SDSED 296_ SSEGL 301_ EDRPL 306_ PVLSL 311_ APAPP 316_ PVAVA 321_ SPSLP 326_ SPPVS 331_ LDPCA 336_ PAPAP 341_ ASALQ 346_ KPKIW 351_ SLAET 356_ ATSPD 361_ NPRRS 366_ PPGAG 371_ GSPPG 376_ AAVAP 381_ SALQL 386_ SPAAA 391_ AAAAH 396_ RLVSA 401_ PLGKF 406_ PAWTN 411_ RPFPG 416_ PPPGP 421_ RLHPL 426_ SLLGS 431_ APPHL 436_ LGLPG 441_ AAGHP 446_ AAAAA 451_ FARPA 456_ EPEGG 461_ TDRCS 466_ ALEVE 471_ KKLLK 476_ TAFQP 481_ VPRRP 486_ QNHLD 491_ AALVL 496_SALSS
1: Transcription factor involved in SHH-dependent neural patterning. Together with NKX2-2 and NKX6-1 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class I proteins of neuronal progenitor factors, which are repressed by SHH signals. Involved in the transcriptional repression of MNX1 in non-motor neuron cells. Acts as a regulator of energy metabolism