Fractalkine (C-X3-C motif chemokine 1) (CX3C membrane-anchored chemokine) (Neurotactin) (Small-inducible cytokine D1) [Cleaved into: Processed fractalkine]
1_MAPIS 6_ LSWLL 11_ RLATF 16_ CHLTV 21_ LLAGQ 26_ HHGVT 31_ KCNIT 36_ CSKMT 41_ SKIPV 46_ ALLIH 51_ YQQNQ 56_ ASCGK 61_ RAIIL 66_ ETRQH 71_ RLFCA 76_ DPKEQ 81_ WVKDA 86_ MQHLD 91_ RQAAA 96_ LTRNG 101_ GTFEK 106_ QIGEV 111_ KPRTT 116_ PAAGG 121_ MDESV 126_ VLEPE 131_ ATGES 136_ SSLEP 141_ TPSSQ 146_ EAQRA 151_ LGTSP 156_ ELPTG 161_ VTGSS 166_ GTRLP 171_ PTPKA 176_ QDGGP 181_ VGTEL 186_ FRVPP 191_ VSTAA 196_ TWQSS 201_ APHQP 206_ GPSLW 211_ AEAKT 216_ SEAPS 221_ TQDPS 226_ TQAST 231_ ASSPA 236_ PEENA 241_ PSEGQ 246_ RVWGQ 251_ GQSPR 256_ PENSL 261_ EREEM 266_ GPVPA 271_ HTDAF 276_ QDWGP 281_ GSMAH 286_ VSVVP 291_ VSSEG 296_ TPSRE 301_ PVASG 306_ SWTPK 311_ AEEPI 316_ HATMD 321_ PQRLG 326_ VLITP 331_ VPDAQ 336_ AATRR 341_ QAVGL 346_ LAFLG 351_ LLFCL 356_ GVAMF 361_ TYQSL 366_ QGCPR 371_ KMAGE 376_ MAEGL 381_ RYIPR 386_ SCGSN 391_SYVLV
1: Chemokine that acts as a ligand for both CX3CR1 and integrins ITGAV:ITGB3 and ITGA4:ITGB1 (PubMed:12055230, PubMed:21829356, PubMed:23125415, PubMed:9782118, PubMed:9931005). The CX3CR1-CX3CL1 signaling exerts distinct functions in different tissue compartments, such as immune response, inflammation, cell adhesion and chemotaxis (PubMed:12055230, PubMed:9024663, PubMed:9177350, PubMed:9782118). Regulates leukocyte adhesion and migration processes at the endothelium (PubMed:9024663, PubMed:9177350). Can activate integrins in both a CX3CR1-dependent and CX3CR1-independent manner (PubMed:23125415, PubMed:24789099). In the presence of CX3CR1, activates integrins by binding to the classical ligand-binding site (site 1) in integrins (PubMed:23125415, PubMed:24789099). In the absence of CX3CR1, binds to a second site (site 2) in integrins which is distinct from site 1 and enhances the binding of other integrin ligands to site 1 (PubMed:23125415, PubMed:24789099)
2: The soluble form is chemotactic for T-cells and monocytes, but not for neutrophils
3: The membrane-bound form promotes adhesion of those leukocytes to endothelial cells
4: (Microbial infection) Mediates the cytoadherence of erythrocytes infected with parasite P.falciparum (strain 3D7) with endothelial cells by interacting with P.falciparum CBP1 and CBP2 expressed at the surface of erythrocytes (PubMed:27653778). The adhesion prevents the elimination of infected erythrocytes by the spleen (Probable)