Homeobox protein Nkx-6.1 (Homeobox protein NK-6 homolog A)
1_MLAVG 6_ AMEGT 11_ RQSAF 16_ LLSSP 21_ PLAAL 26_ HSMAE 31_ MKTPL 36_ YPAAY 41_ PPLPA 46_ GPPSS 51_ SSSSS 56_ SSSSP 61_ SPPLG 66_ THNPG 71_ GLKPP 76_ ATGGL 81_ SSLGS 86_ PPQQL 91_ SAATP 96_ HGIND 101_ ILSRP 106_ SMPVA 111_ SGAAL 116_ PSASP 121_ SGSSS 126_ SSSSS 131_ ASASS 136_ ASAAA 141_ AAAAA 146_ AAAAA 151_ SSPAG 156_ LLAGL 161_ PRFSS 166_ LSPPP 171_ PPPGL 176_ YFSPS 181_ AAAVA 186_ AVGRY 191_ PKPLA 196_ ELPGR 201_ TPIFW 206_ PGVMQ 211_ SPPWR 216_ DARLA 221_ CTPHQ 226_ GSILL 231_ DKDGK 236_ RKHTR 241_ PTFSG 246_ QQIFA 251_ LEKTF 256_ EQTKY 261_ LAGPE 266_ RARLA 271_ YSLGM 276_ TESQV 281_ KVWFQ 286_ NRRTK 291_ WRKKH 296_ AAEMA 301_ TAKKK 306_ QDSET 311_ ERLKG 316_ ASENE 321_ EEDDD 326_ YNKPL 331_ DPNSD 336_ DEKIT 341_ QLLKK 346_ HKSSS 351_ GGGGG 356_ LLLHA 361_SEPES
1: Transcription factor which binds to specific A/T-rich DNA sequences in the promoter regions of a number of genes. Involved in the development of insulin-producing beta cells in the islets of Langerhans at the secondary transition (By similarity). Together with NKX2-2 and IRX3 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class II proteins of neuronal progenitor factors, which are induced by SHH signals (By similarity)