ATP-sensitive inward rectifier potassium channel 10 (ATP-dependent inwardly rectifying potassium channel Kir4.1) (Inward rectifier K(+) channel Kir1.2) (Potassium channel, inwardly rectifying subfamily J member 10)
1_MTSVA 6_ KVYYS 11_ QTTQT 16_ ESRPL 21_ MGPGI 26_ RRRRV 31_ LTKDG 36_ RSNVR 41_ MEHIA 46_ DKRFL 51_ YLKDL 56_ WTTFI 61_ DMQWR 66_ YKLLL 71_ FSATF 76_ AGTWF 81_ LFGVV 86_ WYLVA 91_ VAHGD 96_ LLELD 101_ PPANH 106_ TPCVV 111_ QVHTL 116_ TGAFL 121_ FSLES 126_ QTTIG 131_ YGFRY 136_ ISEEC 141_ PLAIV 146_ LLIAQ 151_ LVLTT 156_ ILEIF 161_ ITGTF 166_ LAKIA 171_ RPKKR 176_ AETIR 181_ FSQHA 186_ VVASH 191_ NGKPC 196_ LMIRV 201_ ANMRK 206_ SLLIG 211_ CQVTG 216_ KLLQT 221_ HQTKE 226_ GENIR 231_ LNQVN 236_ VTFQV 241_ DTASD 246_ SPFLI 251_ LPLTF 256_ YHVVD 261_ ETSPL 266_ KDLPL 271_ RSGEG 276_ DFELV 281_ LILSG 286_ TVEST 291_ SATCQ 296_ VRTSY 301_ LPEEI 306_ LWGYE 311_ FTPAI 316_ SLSAS 321_ GKYIA 326_ DFSLF 331_ DQVVK 336_ VASPS 341_ GLRDS 346_ TVRYG 351_ DPEKL 356_ KLEES 361_ LREQA 366_ EKEGS 371_ALSVR
1: May be responsible for potassium buffering action of glial cells in the brain (By similarity). Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it (PubMed:8995301). Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages (PubMed:8995301). The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium (PubMed:8995301). In the kidney, together with KCNJ16, mediates basolateral K(+) recycling in distal tubules; this process is critical for Na(+) reabsorption at the tubules (PubMed:24561201)