DENN domain-containing protein 2B (HeLa tumor suppression 1) (Suppression of tumorigenicity 5 protein)
1_MTMTA 6_ NKNSS 11_ ITHGA 16_ GGTKA 21_ PRGTL 26_ SRSQS 31_ VSPPP 36_ VLSPP 41_ RSPIY 46_ PLSDS 51_ ETSAC 56_ RYPSH 61_ SSSRV 66_ LLKDR 71_ HPPAP 76_ SPQNP 81_ QDPSP 86_ DTSPP 91_ TCPFK 96_ TASFG 101_ YLDRS 106_ PSACK 111_ RDAQK 116_ ESVQG 121_ AAQDV 126_ AGVAA 131_ CLPLA 136_ QSTPF 141_ PGPAA 146_ GPRGV 151_ LLTRT 156_ GTRAH 161_ SLGIR 166_ EKISA 171_ WEGRR 176_ EASPR 181_ MSMCG 186_ EKREG 191_ SGSEW 196_ AASEG 201_ CPSLG 206_ CPSVV 211_ PSPCS 216_ SEKTF 221_ DFKGL 226_ RRMSR 231_ TFSEC 236_ SYPET 241_ EEEGE 246_ ALPVR 251_ DSFYR 256_ LEKRL 261_ GRSEP 266_ SAFLR 271_ GHGSR 276_ KESSA 281_ VLSRI 286_ QKIEQ 291_ VLKEQ 296_ PGRGL 301_ PQLPS 306_ SCYSV 311_ DRGKR 316_ KTGTL 321_ GSLEE 326_ PAGGA 331_ SVSAG 336_ SRAVG 341_ VAGVA 346_ GEAGP 351_ PPERE 356_ GSGST 361_ KPGTP 366_ GNSPS 371_ SQRLP 376_ SKSSL 381_ DPAVN 386_ PVPKP 391_ KRTFE 396_ YEADK 401_ NPKSK 406_ PSNGL 411_ PPSPT 416_ PAAPP 421_ PLPST 426_ PAPPV 431_ TRRPK 436_ KDMRG 441_ HRKSQ 446_ SRKSF 451_ EFEDA 456_ SSLQS 461_ LYPSS 466_ PTENG 471_ TENQP 476_ KFGSK 481_ STLEE 486_ NAYED 491_ IVGDL 496_ PKENP 501_ YEDVD 506_ LKSRR 511_ AGRKS 516_ QQLSE 521_ NSLDS 526_ LHRMW 531_ SPQDR 536_ KYNSP 541_ PTQLS 546_ LKPNS 551_ QSLRS 556_ GNWSE 561_ RKSHR 566_ LPRLP 571_ KRHSH 576_ DDMLL 581_ LAQLS 586_ LPSSP 591_ SSLNE 596_ DSLST 601_ TSELL 606_ SSRRA 611_ RRIPK 616_ LVQRI 621_ NSIYN 626_ AKRGK 631_ KRLKK 636_ LSMSS 641_ IETAS 646_ LRDEN 651_ SESES 656_ DSDDR 661_ FKAHT 666_ QRLVH 671_ IQSML 676_ KRAPS 681_ YRTLE 686_ LELLE 691_ WQERE 696_ LFEYF 701_ VVVSL 706_ KKKPS 711_ RNTYL 716_ PEVSY 721_ QFPKL 726_ DRPTK 731_ QMREA 736_ EERLK 741_ AIPQF 746_ CFPDA 751_ KDWLP 756_ VSEYS 761_ SETFS 766_ FMLTG 771_ EDGSR 776_ RFGYC 781_ RRLLP 786_ SGKGP 791_ RLPEV 796_ YCVIS 801_ RLGCF 806_ GLFSK 811_ VLDEV 816_ ERRRG 821_ ISAAL 826_ VYPFM 831_ RSLME 836_ SPFPA 841_ PGKTI 846_ KVKTF 851_ LPGAG 856_ NEVLE 861_ LRRPM 866_ DSRLE 871_ HVDFE 876_ CLFTC 881_ LSVRQ 886_ LIRIF 891_ ASLLL 896_ ERRVI 901_ FVADK 906_ LSTLS 911_ SCSHA 916_ VVALL 921_ YPFSW 926_ QHTFI 931_ PVLPA 936_ SMIDI 941_ VCCPT 946_ PFLVG 951_ LLSSS 956_ LPKLK 961_ ELPVE 966_ EALMV 971_ NLGSD 976_ RFIRQ 981_ MDDED 986_ TLLPR 991_ KLQAA 996_ LEQAL 1001_ ERKNE 1006_ LISQD 1011_ SDSDS 1016_ DDECN 1021_ TLNGL 1026_ VSEVF 1031_ IRFFV 1036_ ETVGH 1041_ YSLFL 1046_ TQSEK 1051_ GERAF 1056_ QREAF 1061_ RKSVA 1066_ SKSIR 1071_ RFLEV 1076_ FMESQ 1081_ MFAGF 1086_ IQDRE 1091_ LRKCR 1096_ AKGLF 1101_ EQRVE 1106_ QYLEE 1111_ LPDTE 1116_ QSGMN 1121_ KFLRG 1126_ LGNKM 1131_KFLHK
1: May be involved in cytoskeletal organization and tumorogenicity. Seems to be involved in a signaling transduction pathway leading to activation of MAPK1/ERK2. Plays a role in EGFR trafficking from recycling endosomes back to the cell membrane (PubMed:29030480)
2: Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form
3: May block ERK2 activation stimulated by ABL1 (Probable). May alter cell morphology and cell growth (Probable)