DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit) (DNA-PKcs) (EC 2.7.11.1) (DNPK1) (p460)
1_MAGSG 6_ AGVRC 11_ SLLRL 16_ QETLS 21_ AADRC 26_ GAALA 31_ GHQLI 36_ RGLGQ 41_ ECVLS 46_ SSPAV 51_ LALQT 56_ SLVFS 61_ RDFGL 66_ LVFVR 71_ KSLNS 76_ IEFRE 81_ CREEI 86_ LKFLC 91_ IFLEK 96_ MGQKI 101_ APYSV 106_ EIKNT 111_ CTSVY 116_ TKDRA 121_ AKCKI 126_ PALDL 131_ LIKLL 136_ QTFRS 141_ SRLMD 146_ EFKIG 151_ ELFSK 156_ FYGEL 161_ ALKKK 166_ IPDTV 171_ LEKVY 176_ ELLGL 181_ LGEVH 186_ PSEMI 191_ NNAEN 196_ LFRAF 201_ LGELK 206_ TQMTS 211_ AVREP 216_ KLPVL 221_ AGCLK 226_ GLSSL 231_ LCNFT 236_ KSMEE 241_ DPQTS 246_ REIFN 251_ FVLKA 256_ IRPQI 261_ DLKRY 266_ AVPSA 271_ GLRLF 276_ ALHAS 281_ QFSTC 286_ LLDNY 291_ VSLFE 296_ VLLKW 301_ CAHTN 306_ VELKK 311_ AALSA 316_ LESFL 321_ KQVSN 326_ MVAKN 331_ AEMHK 336_ NKLQY 341_ FMEQF 346_ YGIIR 351_ NVDSN 356_ NKELS 361_ IAIRG 366_ YGLFA 371_ GPCKV 376_ INAKD 381_ VDFMY 386_ VELIQ 391_ RCKQM 396_ FLTQT 401_ DTGDD 406_ RVYQM 411_ PSFLQ 416_ SVASV 421_ LLYLD 426_ TVPEV 431_ YTPVL 436_ EHLVV 441_ MQIDS 446_ FPQYS 451_ PKMQL 456_ VCCRA 461_ IVKVF 466_ LALAA 471_ KGPVL 476_ RNCIS 481_ TVVHQ 486_ GLIRI 491_ CSKPV 496_ VLPKG 501_ PESES 506_ EDHRA 511_ SGEVR 516_ TGKWK 521_ VPTYK 526_ DYVDL 531_ FRHLL 536_ SSDQM 541_ MDSIL 546_ ADEAF 551_ FSVNS 556_ SSESL 561_ NHLLY 566_ DEFVK 571_ SVLKI 576_ VEKLD 581_ LTLEI 586_ QTVGE 591_ QENGD 596_ EAPGV 601_ WMIPT 606_ SDPAA 611_ NLHPA 616_ KPKDF 621_ SAFIN 626_ LVEFC 631_ REILP 636_ EKQAE 641_ FFEPW 646_ VYSFS 651_ YELIL 656_ QSTRL 661_ PLISG 666_ FYKLL 671_ SITVR 676_ NAKKI 681_ KYFEG 686_ VSPKS 691_ LKHSP 696_ EDPEK 701_ YSCFA 706_ LFVKF 711_ GKEVA 716_ VKMKQ 721_ YKDEL 726_ LASCL 731_ TFLLS 736_ LPHNI 741_ IELDV 746_ RAYVP 751_ ALQMA 756_ FKLGL 761_ SYTPL 766_ AEVGL 771_ NALEE 776_ WSIYI 781_ DRHVM 786_ QPYYK 791_ DILPC 796_ LDGYL 801_ KTSAL 806_ SDETK 811_ NNWEV 816_ SALSR 821_ AAQKG 826_ FNKVV 831_ LKHLK 836_ KTKNL 841_ SSNEA 846_ ISLEE 851_ IRIRV 856_ VQMLG 861_ SLGGQ 866_ INKNL 871_ LTVTS 876_ SDEMM 881_ KSYVA 886_ WDREK 891_ RLSFA 896_ VPFRE 901_ MKPVI 906_ FLDVF 911_ LPRVT 916_ ELALT 921_ ASDRQ 926_ TKVAA 931_ CELLH 936_ SMVMF 941_ MLGKA 946_ TQMPE 951_ GGQGA 956_ PPMYQ 961_ LYKRT 966_ FPVLL 971_ RLACD 976_ VDQVT 981_ RQLYE 986_ PLVMQ 991_ LIHWF 996_ TNNKK 1001_ FESQD 1006_ TVALL 1011_ EAILD 1016_ GIVDP 1021_ VDSTL 1026_ RDFCG 1031_ RCIRE 1036_ FLKWS 1041_ IKQIT 1046_ PQQQE 1051_ KSPVN 1056_ TKSLF 1061_ KRLYS 1066_ LALHP 1071_ NAFKR 1076_ LGASL 1081_ AFNNI 1086_ YREFR 1091_ EEESL 1096_ VEQFV 1101_ FEALV 1106_ IYMES 1111_ LALAH 1116_ ADEKS 1121_ LGTIQ 1126_ QCCDA 1131_ IDHLC 1136_ RIIEK 1141_ KHVSL 1146_ NKAKK 1151_ RRLPR 1156_ GFPPS 1161_ ASLCL 1166_ LDLVK 1171_ WLLAH 1176_ CGRPQ 1181_ TECRH 1186_ KSIEL 1191_ FYKFV 1196_ PLLPG 1201_ NRSPN 1206_ LWLKD 1211_ VLKEE 1216_ GVSFL 1221_ INTFE 1226_ GGGCG 1231_ QPSGI 1236_ LAQPT 1241_ LLYLR 1246_ GPFSL 1251_ QATLC 1256_ WLDLL 1261_ LAALE 1266_ CYNTF 1271_ IGERT 1276_ VGALQ 1281_ VLGTE 1286_ AQSSL 1291_ LKAVA 1296_ FFLES 1301_ IAMHD 1306_ IIAAE 1311_ KCFGT 1316_ GAAGN 1321_ RTSPQ 1326_ EGERY 1331_ NYSKC 1336_ TVVVR 1341_ IMEFT 1346_ TTLLN 1351_ TSPEG 1356_ WKLLK 1361_ KDLCN 1366_ THLMR 1371_ VLVQT 1376_ LCEPA 1381_ SIGFN 1386_ IGDVQ 1391_ VMAHL 1396_ PDVCV 1401_ NLMKA 1406_ LKMSP 1411_ YKDIL 1416_ ETHLR 1421_ EKITA 1426_ QSIEE 1431_ LCAVN 1436_ LYGPD 1441_ AQVDR 1446_ SRLAA 1451_ VVSAC 1456_ KQLHR 1461_ AGLLH 1466_ NILPS 1471_ QSTDL 1476_ HHSVG 1481_ TELLS 1486_ LVYKG 1491_ IAPGD 1496_ ERQCL 1501_ PSLDL 1506_ SCKQL 1511_ ASGLL 1516_ ELAFA 1521_ FGGLC 1526_ ERLVS 1531_ LLLNP 1536_ AVLST 1541_ ASLGS 1546_ SQGSV 1551_ IHFSH 1556_ GEYFY 1561_ SLFSE 1566_ TINTE 1571_ LLKNL 1576_ DLAVL 1581_ ELMQS 1586_ SVDNT 1591_ KMVSA 1596_ VLNGM 1601_ LDQSF 1606_ RERAN 1611_ QKHQG 1616_ LKLAT 1621_ TILQH 1626_ WKKCD 1631_ SWWAK 1636_ DSPLE 1641_ TKMAV 1646_ LALLA 1651_ KILQI 1656_ DSSVS 1661_ FNTSH 1666_ GSFPE 1671_ VFTTY 1676_ ISLLA 1681_ DTKLD 1686_ LHLKG 1691_ QAVTL 1696_ LPFFT 1701_ SLTGG 1706_ SLEEL 1711_ RRVLE 1716_ QLIVA 1721_ HFPMQ 1726_ SREFP 1731_ PGTPR 1736_ FNNYV 1741_ DCMKK 1746_ FLDAL 1751_ ELSQS 1756_ PMLLE 1761_ LMTEV 1766_ LCREQ 1771_ QHVME 1776_ ELFQS 1781_ SFRRI 1786_ ARRGS 1791_ CVTQV 1796_ GLLES 1801_ VYEMF 1806_ RKDDP 1811_ RLSFT 1816_ RQSFV 1821_ DRSLL 1826_ TLLWH 1831_ CSLDA 1836_ LREFF 1841_ STIVV 1846_ DAIDV 1851_ LKSRF 1856_ TKLNE 1861_ STFDT 1866_ QITKK 1871_ MGYYK 1876_ ILDVM 1881_ YSRLP 1886_ KDDVH 1891_ AKESK 1896_ INQVF 1901_ HGSCI 1906_ TEGNE 1911_ LTKTL 1916_ IKLCY 1921_ DAFTE 1926_ NMAGE 1931_ NQLLE 1936_ RRRLY 1941_ HCAAY 1946_ NCAIS 1951_ VICCV 1956_ FNELK 1961_ FYQGF 1966_ LFSEK 1971_ PEKNL 1976_ LIFEN 1981_ LIDLK 1986_ RRYNF 1991_ PVEVE 1996_ VPMER 2001_ KKKYI 2006_ EIRKE 2011_ AREAA 2016_ NGDSD 2021_ GPSYM 2026_ SSLSY 2031_ LADST 2036_ LSEEM 2041_ SQFDF 2046_ STGVQ 2051_ SYSYS 2056_ SQDPR 2061_ PATGR 2066_ FRRRE 2071_ QRDPT 2076_ VHDDV 2081_ LELEM 2086_ DELNR 2091_ HECMA 2096_ PLTAL 2101_ VKHMH 2106_ RSLGP 2111_ PQGEE 2116_ DSVPR 2121_ DLPSW 2126_ MKFLH 2131_ GKLGN 2136_ PIVPL 2141_ NIRLF 2146_ LAKLV 2151_ INTEE 2156_ VFRPY 2161_ AKHWL 2166_ SPLLQ 2171_ LAASE 2176_ NNGGE 2181_ GIHYM 2186_ VVEIV 2191_ ATILS 2196_ WTGLA 2201_ TPTGV 2206_ PKDEV 2211_ LANRL 2216_ LNFLM 2221_ KHVFH 2226_ PKRAV 2231_ FRHNL 2236_ EIIKT 2241_ LVECW 2246_ KDCLS 2251_ IPYRL 2256_ IFEKF 2261_ SGKDP 2266_ NSKDN 2271_ SVGIQ 2276_ LLGIV 2281_ MANDL 2286_ PPYDP 2291_ QCGIQ 2296_ SSEYF 2301_ QALVN 2306_ NMSFV 2311_ RYKEV 2316_ YAAAA 2321_ EVLGL 2326_ ILRYV 2331_ MERKN 2336_ ILEES 2341_ LCELV 2346_ AKQLK 2351_ QHQNT 2356_ MEDKF 2361_ IVCLN 2366_ KVTKS 2371_ FPPLA 2376_ DRFMN 2381_ AVFFL 2386_ LPKFH 2391_ GVLKT 2396_ LCLEV 2401_ VLCRV 2406_ EGMTE 2411_ LYFQL 2416_ KSKDF 2421_ VQVMR 2426_ HRDDE 2431_ RQKVC 2436_ LDIIY 2441_ KMMPK 2446_ LKPVE 2451_ LRELL 2456_ NPVVE 2461_ FVSHP 2466_ STTCR 2471_ EQMYN 2476_ ILMWI 2481_ HDNYR 2486_ DPESE 2491_ TDNDS 2496_ QEIFK 2501_ LAKDV 2506_ LIQGL 2511_ IDENP 2516_ GLQLI 2521_ IRNFW 2526_ SHETR 2531_ LPSNT 2536_ LDRLL 2541_ ALNSL 2546_ YSPKI 2551_ EVHFL 2556_ SLATN 2561_ FLLEM 2566_ TSMSP 2571_ DYPNP 2576_ MFEHP 2581_ LSECE 2586_ FQEYT 2591_ IDSDW 2596_ RFRST 2601_ VLTPM 2606_ FVETQ 2611_ ASQGT 2616_ LQTRT 2621_ QEGSL 2626_ SARWP 2631_ VAGQI 2636_ RATQQ 2641_ QHDFT 2646_ LTQTA 2651_ DGRSS 2656_ FDWLT 2661_ GSSTD 2666_ PLVDH 2671_ TSPSS 2676_ DSLLF 2681_ AHKRS 2686_ ERLQR 2691_ APLKS 2696_ VGPDF 2701_ GKKRL 2706_ GLPGD 2711_ EVDNK 2716_ VKGAA 2721_ GRTDL 2726_ LRLRR 2731_ RFMRD 2736_ QEKLS 2741_ LMYAR 2746_ KGVAE 2751_ QKREK 2756_ EIKSE 2761_ LKMKQ 2766_ DAQVV 2771_ LYRSY 2776_ RHGDL 2781_ PDIQI 2786_ KHSSL 2791_ ITPLQ 2796_ AVAQR 2801_ DPIIA 2806_ KQLFS 2811_ SLFSG 2816_ ILKEM 2821_ DKFKT 2826_ LSEKN 2831_ NITQK 2836_ LLQDF 2841_ NRFLN 2846_ TTFSF 2851_ FPPFV 2856_ SCIQD 2861_ ISCQH 2866_ AALLS 2871_ LDPAA 2876_ VSAGC 2881_ LASLQ 2886_ QPVGI 2891_ RLLEE 2896_ ALLRL 2901_ LPAEL 2906_ PAKRV 2911_ RGKAR 2916_ LPPDV 2921_ LRWVE 2926_ LAKLY 2931_ RSIGE 2936_ YDVLR 2941_ GIFTS 2946_ EIGTK 2951_ QITQS 2956_ ALLAE 2961_ ARSDY 2966_ SEAAK 2971_ QYDEA 2976_ LNKQD 2981_ WVDGE 2986_ PTEAE 2991_ KDFWE 2996_ LASLD 3001_ CYNHL 3006_ AEWKS 3011_ LEYCS 3016_ TASID 3021_ SENPP 3026_ DLNKI 3031_ WSEPF 3036_ YQETY 3041_ LPYMI 3046_ RSKLK 3051_ LLLQG 3056_ EADQS 3061_ LLTFI 3066_ DKAMH 3071_ GELQK 3076_ AILEL 3081_ HYSQE 3086_ LSLLY 3091_ LLQDD 3096_ VDRAK 3101_ YYIQN 3106_ GIQSF 3111_ MQNYS 3116_ SIDVL 3121_ LHQSR 3126_ LTKLQ 3131_ SVQAL 3136_ TEIQE 3141_ FISFI 3146_ SKQGN 3151_ LSSQV 3156_ PLKRL 3161_ LNTWT 3166_ NRYPD 3171_ AKMDP 3176_ MNIWD 3181_ DIITN 3186_ RCFFL 3191_ SKIEE 3196_ KLTPL 3201_ PEDNS 3206_ MNVDQ 3211_ DGDPS 3216_ DRMEV 3221_ QEQEE 3226_ DISSL 3231_ IRSCK 3236_ FSMKM 3241_ KMIDS 3246_ ARKQN 3251_ NFSLA 3256_ MKLLK 3261_ ELHKE 3266_ SKTRD 3271_ DWLVS 3276_ WVQSY 3281_ CRLSH 3286_ CRSRS 3291_ QGCSE 3296_ QVLTV 3301_ LKTVS 3306_ LLDEN 3311_ NVSSY 3316_ LSKNI 3321_ LAFRD 3326_ QNILL 3331_ GTTYR 3336_ IIANA 3341_ LSSEP 3346_ ACLAE 3351_ IEEDK 3356_ ARRIL 3361_ ELSGS 3366_ SSEDS 3371_ EKVIA 3376_ GLYQR 3381_ AFQHL 3386_ SEAVQ 3391_ AAEEE 3396_ AQPPS 3401_ WSCGP 3406_ AAGVI 3411_ DAYMT 3416_ LADFC 3421_ DQQLR 3426_ KEEEN 3431_ ASVID 3436_ SAELQ 3441_ AYPAL 3446_ VVEKM 3451_ LKALK 3456_ LNSNE 3461_ ARLKF 3466_ PRLLQ 3471_ IIERY 3476_ PEETL 3481_ SLMTK 3486_ EISSV 3491_ PCWQF 3496_ ISWIS 3501_ HMVAL 3506_ LDKDQ 3511_ AVAVQ 3516_ HSVEE 3521_ ITDNY 3526_ PQAIV 3531_ YPFII 3536_ SSESY 3541_ SFKDT 3546_ STGHK 3551_ NKEFV 3556_ ARIKS 3561_ KLDQG 3566_ GVIQD 3571_ FINAL 3576_ DQLSN 3581_ PELLF 3586_ KDWSN 3591_ DVRAE 3596_ LAKTP 3601_ VNKKN 3606_ IEKMY 3611_ ERMYA 3616_ ALGDP 3621_ KAPGL 3626_ GAFRR 3631_ KFIQT 3636_ FGKEF 3641_ DKHFG 3646_ KGGSK 3651_ LLRMK 3656_ LSDFN 3661_ DITNM 3666_ LLLKM 3671_ NKDSK 3676_ PPGNL 3681_ KECSP 3686_ WMSDF 3691_ KVEFL 3696_ RNELE 3701_ IPGQY 3706_ DGRGK 3711_ PLPEY 3716_ HVRIA 3721_ GFDER 3726_ VTVMA 3731_ SLRRP 3736_ KRIII 3741_ RGHDE 3746_ REHPF 3751_ LVKGG 3756_ EDLRQ 3761_ DQRVE 3766_ QLFQV 3771_ MNGIL 3776_ AQDSA 3781_ CSQRA 3786_ LQLRT 3791_ YSVVP 3796_ MTSRL 3801_ GLIEW 3806_ LENTV 3811_ TLKDL 3816_ LLNTM 3821_ SQEEK 3826_ AAYLS 3831_ DPRAP 3836_ PCEYK 3841_ DWLTK 3846_ MSGKH 3851_ DVGAY 3856_ MLMYK 3861_ GANRT 3866_ ETVTS 3871_ FRKRE 3876_ SKVPA 3881_ DLLKR 3886_ AFVRM 3891_ STSPE 3896_ AFLAL 3901_ RSHFA 3906_ SSHAL 3911_ ICISH 3916_ WILGI 3921_ GDRHL 3926_ NNFMV 3931_ AMETG 3936_ GVIGI 3941_ DFGHA 3946_ FGSAT 3951_ QFLPV 3956_ PELMP 3961_ FRLTR 3966_ QFINL 3971_ MLPMK 3976_ ETGLM 3981_ YSIMV 3986_ HALRA 3991_ FRSDP 3996_ GLLTN 4001_ TMDVF 4006_ VKEPS 4011_ FDWKN 4016_ FEQKM 4021_ LKKGG 4026_ SWIQE 4031_ INVAE 4036_ KNWYP 4041_ RQKIC 4046_ YAKRK 4051_ LAGAN 4056_ PAVIT 4061_ CDELL 4066_ LGHEK 4071_ APAFR 4076_ DYVAV 4081_ ARGSK 4086_ DHNIR 4091_ AQEPE 4096_ SGLSE 4101_ ETQVK 4106_ CLMDQ 4111_ ATDPN 4116_ ILGRT 4121_WEGWE
1: Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234). Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234, PubMed:34352203). Must be bound to DNA to express its catalytic properties (PubMed:11955432). Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C) (PubMed:11955432). Recruited by XRCC5 and XRCC6 to DNA ends and is required to (1) protect and align broken ends of DNA, thereby preventing their degradation, (2) and sequester the DSB for repair by NHEJ (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326, PubMed:33854234). Acts as a scaffold protein to aid the localization of DNA repair proteins to the site of damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion (By similarity). Also involved in modulation of transcription (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). As part of the DNA-PK complex, involved in the early steps of ribosome assembly by promoting the processing of precursor rRNA into mature 18S rRNA in the small-subunit processome (PubMed:32103174). Binding to U3 small nucleolar RNA, recruits PRKDC and XRCC5/Ku86 to the small-subunit processome (PubMed:32103174). Recognizes the substrate consensus sequence [ST]-Q (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Phosphorylates 'Ser-139' of histone variant H2AX, thereby regulating DNA damage response mechanism (PubMed:14627815, PubMed:16046194). Phosphorylates ASF1A, DCLRE1C, c-Abl/ABL1, histone H1, HSPCA, c-jun/JUN, p53/TP53, PARP1, POU2F1, DHX9, FH, SRF, NHEJ1/XLF, XRCC1, XRCC4, XRCC5, XRCC6, WRN, MYC and RFA2 (PubMed:10026262, PubMed:10467406, PubMed:11889123, PubMed:12509254, PubMed:14599745, PubMed:14612514, PubMed:14704337, PubMed:15177042, PubMed:1597196, PubMed:16397295, PubMed:18644470, PubMed:2247066, PubMed:2507541, PubMed:26237645, PubMed:26666690, PubMed:28712728, PubMed:29478807, PubMed:30247612, PubMed:8407951, PubMed:8464713, PubMed:9139719, PubMed:9362500). Can phosphorylate C1D not only in the presence of linear DNA but also in the presence of supercoiled DNA (PubMed:9679063). Ability to phosphorylate p53/TP53 in the presence of supercoiled DNA is dependent on C1D (PubMed:9363941). Acts as a regulator of the phosphatidylinositol 3-kinase/protein kinase B signal transduction by mediating phosphorylation of 'Ser-473' of protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), promoting their activation (PubMed:15262962). Contributes to the determination of the circadian period length by antagonizing phosphorylation of CRY1 'Ser-588' and increasing CRY1 protein stability, most likely through an indirect mechanism (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Also regulates the cGAS-STING pathway by catalyzing phosphorylation of CGAS, thereby impairing CGAS oligomerization and activation (PubMed:33273464). Also regulates the cGAS-STING pathway by mediating phosphorylation of PARP1 (PubMed:35460603)