Disintegrin and metalloproteinase domain-containing protein 17 (ADAM 17) (EC 3.4.24.86) (Snake venom-like protease) (TNF-alpha convertase) (TNF-alpha-converting enzyme) (CD antigen CD156b)
1_MRQSL 6_ LFLTS 11_ VVPFV 16_ LAPRP 21_ PDDPG 26_ FGPHQ 31_ RLEKL 36_ DSLLS 41_ DYDIL 46_ SLSNI 51_ QQHSV 56_ RKRDL 61_ QTSTH 66_ VETLL 71_ TFSAL 76_ KRHFK 81_ LYLTS 86_ STERF 91_ SQNFK 96_ VVVVD 101_ GKNES 106_ EYTVK 111_ WQDFF 116_ TGHVV 121_ GEPDS 126_ RVLAH 131_ IRDDD 136_ VIIRI 141_ NTDGA 146_ EYNIE 151_ PLWRF 156_ VNDTK 161_ DKRML 166_ VYKSE 171_ DIKNV 176_ SRLQS 181_ PKVCG 186_ YLKVD 191_ NEELL 196_ PKGLV 201_ DREPP 206_ EELVH 211_ RVKRR 216_ ADPDP 221_ MKNTC 226_ KLLVV 231_ ADHRF 236_ YRYMG 241_ RGEES 246_ TTTNY 251_ LIELI 256_ DRVDD 261_ IYRNT 266_ SWDNA 271_ GFKGY 276_ GIQIE 281_ QIRIL 286_ KSPQE 291_ VKPGE 296_ KHYNM 301_ AKSYP 306_ NEEKD 311_ AWDVK 316_ MLLEQ 321_ FSFDI 326_ AEEAS 331_ KVCLA 336_ HLFTY 341_ QDFDM 346_ GTLGL 351_ AYVGS 356_ PRANS 361_ HGGVC 366_ PKAYY 371_ SPVGK 376_ KNIYL 381_ NSGLT 386_ STKNY 391_ GKTIL 396_ TKEAD 401_ LVTTH 406_ ELGHN 411_ FGAEH 416_ DPDGL 421_ AECAP 426_ NEDQG 431_ GKYVM 436_ YPIAV 441_ SGDHE 446_ NNKMF 451_ SNCSK 456_ QSIYK 461_ TIESK 466_ AQECF 471_ QERSN 476_ KVCGN 481_ SRVDE 486_ GEECD 491_ PGIMY 496_ LNNDT 501_ CCNSD 506_ CTLKE 511_ GVQCS 516_ DRNSP 521_ CCKNC 526_ QFETA 531_ QKKCQ 536_ EAINA 541_ TCKGV 546_ SYCTG 551_ NSSEC 556_ PPPGN 561_ AEDDT 566_ VCLDL 571_ GKCKD 576_ GKCIP 581_ FCERE 586_ QQLES 591_ CACNE 596_ TDNSC 601_ KVCCR 606_ DLSGR 611_ CVPYV 616_ DAEQK 621_ NLFLR 626_ KGKPC 631_ TVGFC 636_ DMNGK 641_ CEKRV 646_ QDVIE 651_ RFWDF 656_ IDQLS 661_ INTFG 666_ KFLAD 671_ NIVGS 676_ VLVFS 681_ LIFWI 686_ PFSIL 691_ VHCVD 696_ KKLDK 701_ QYESL 706_ SLFHP 711_ SNVEM 716_ LSSMD 721_ SASVR 726_ IIKPF 731_ PAPQT 736_ PGRLQ 741_ PAPVI 746_ PSAPA 751_ APKLD 756_ HQRMD 761_ TIQED 766_ PSTDS 771_ HMDED 776_ GFEKD 781_ PFPNS 786_ STAAK 791_ SFEDL 796_ TDHPV 801_ TRSEK 806_ AASFK 811_ LQRQN 816_RVDSK
1: Transmembrane metalloprotease which mediates the ectodomain shedding of a myriad of transmembrane proteins including adhesion proteins, growth factor precursors and cytokines important for inflammation and immunity (PubMed:24226769, PubMed:24227843, PubMed:28060820, PubMed:28923481). Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form (PubMed:36078095, PubMed:9034191). Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface (PubMed:20592283). Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein (PubMed:12441351). Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT) (PubMed:24226769). Plays a role in the proteolytic processing of ACE2 (PubMed:24227843). Plays a role in hemostasis through shedding of GP1BA, the platelet glycoprotein Ib alpha chain (By similarity). Mediates the proteolytic cleavage of LAG3, leading to release the secreted form of LAG3 (By similarity). Mediates the proteolytic cleavage of IL6R, leading to the release of secreted form of IL6R (PubMed:26876177, PubMed:28060820). Mediates the proteolytic cleavage and shedding of FCGR3A upon NK cell stimulation, a mechanism that allows for increased NK cell motility and detachment from opsonized target cells. Cleaves TREM2, resulting in shedding of the TREM2 ectodomain (PubMed:28923481)