Arginase-2, mitochondrial (EC 3.5.3.1) (Arginase II) (Kidney-type arginase) (Non-hepatic arginase) (Type II arginase)
1_MSLRG 6_ SLSRL 11_ LQTRV 16_ HSILK 21_ KSVHS 26_ VAVIG 31_ APFSQ 36_ GQKRK 41_ GVEHG 46_ PAAIR 51_ EAGLM 56_ KRLSS 61_ LGCHL 66_ KDFGD 71_ LSFTP 76_ VPKDD 81_ LYNNL 86_ IVNPR 91_ SVGLA 96_ NQELA 101_ EVVSR 106_ AVSDG 111_ YSCVT 116_ LGGDH 121_ SLAIG 126_ TISGH 131_ ARHCP 136_ DLCVV 141_ WVDAH 146_ ADINT 151_ PLTTS 156_ SGNLH 161_ GQPVS 166_ FLLRE 171_ LQDKV 176_ PQLPG 181_ FSWIK 186_ PCISS 191_ ASIVY 196_ IGLRD 201_ VDPPE 206_ HFILK 211_ NYDIQ 216_ YFSMR 221_ DIDRL 226_ GIQKV 231_ MERTF 236_ DLLIG 241_ KRQRP 246_ IHLSF 251_ DIDAF 256_ DPTLA 261_ PATGT 266_ PVVGG 271_ LTYRE 276_ GMYIA 281_ EEIHN 286_ TGLLS 291_ ALDLV 296_ EVNPQ 301_ LATSE 306_ EEAKT 311_ TANLA 316_ VDVIA 321_ SSFGQ 326_ TREGG 331_ HIVYD 336_ QLPTP 341_ SSPDE 346_SENQA
1: May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to nitric oxid synthase (NOS). Arginine metabolism is a critical regulator of innate and adaptive immune responses. Seems to be involved in negative regulation of the survival capacity of activated CD4(+) and CD8(+) T cells (PubMed:27745970). May suppress inflammation-related signaling in asthmatic airway epithelium (PubMed:27214549). May contribute to the immune evasion of H.pylori by restricting M1 macrophage activation and polyamine metabolism (By similarity). In fetal dendritic cells may play a role in promoting immune suppression and T cell TNF-alpha production during gestation (PubMed:28614294). Regulates RPS6KB1 signaling, which promotes endothelial cell senescence and inflammation and implicates NOS3/eNOS dysfunction (PubMed:22928666). Can inhibit endothelial autophagy independently of its enzymatic activity implicating mTORC2 signaling (PubMed:25484082). Involved in vascular smooth muscle cell senescence and apoptosis independently of its enzymatic activity (PubMed:23832324). Since NOS is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase-2 plays a role in both male and female sexual arousal (PubMed:12859189)