Protein BTG2 (BTG family member 2) (NGF-inducible anti-proliferative protein PC3)
1_MSHGK 6_ GTDML 11_ PEIAA 16_ AVGFL 21_ SSLLR 26_ TRGCV 31_ SEQRL 36_ KVFSG 41_ ALQEA 46_ LTEHY 51_ KHHWF 56_ PEKPS 61_ KGSGY 66_ RCIRI 71_ NHKMD 76_ PIISR 81_ VASQI 86_ GLSQP 91_ QLHQL 96_ LPSEL 101_ TLWVD 106_ PYEVS 111_ YRIGE 116_ DGSIC 121_ VLYEE 126_ APLAA 131_ SCGLL 136_ TCKNQ 141_ VLLGR 146_ SSPSK 151_NYVMA
1: Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex. Activates mRNA deadenylation in a CNOT6 and CNOT7-dependent manner. In vitro can inhibit deadenylase activity of CNOT7 and CNOT8. Involved in cell cycle regulation. Could be involved in the growth arrest and differentiation of the neuronal precursors (By similarity). Modulates transcription regulation mediated by ESR1. Involved in mitochondrial depolarization and neurite outgrowth