ETS-related transcription factor Elf-3 (E74-like factor 3) (Epithelial-restricted with serine box) (Epithelium-restricted Ets protein ESX) (Epithelium-specific Ets transcription factor 1) (ESE-1)
1_MAATC 6_ EISNI 11_ FSNYF 16_ SAMYS 21_ SEDST 26_ LASVP 31_ PAATF 36_ GADDL 41_ VLTLS 46_ NPQMS 51_ LEGTE 56_ KASWL 61_ GEQPQ 66_ FWSKT 71_ QVLDW 76_ ISYQV 81_ EKNKY 86_ DASAI 91_ DFSRC 96_ DMDGA 101_ TLCNC 106_ ALEEL 111_ RLVFG 116_ PLGDQ 121_ LHAQL 126_ RDLTS 131_ SSSDE 136_ LSWII 141_ ELLEK 146_ DGMAF 151_ QEALD 156_ PGPFD 161_ QGSPF 166_ AQELL 171_ DDGQQ 176_ ASPYH 181_ PGSCG 186_ AGAPS 191_ PGSSD 196_ VSTAG 201_ TGASR 206_ SSHSS 211_ DSGGS 216_ DVDLD 221_ PTDGK 226_ LFPSD 231_ GFRDC 236_ KKGDP 241_ KHGKR 246_ KRGRP 251_ RKLSK 256_ EYWDC 261_ LEGKK 266_ SKHAP 271_ RGTHL 276_ WEFIR 281_ DILIH 286_ PELNE 291_ GLMKW 296_ ENRHE 301_ GVFKF 306_ LRSEA 311_ VAQLW 316_ GQKKK 321_ NSNMT 326_ YEKLS 331_ RAMRY 336_ YYKRE 341_ ILERV 346_ DGRRL 351_ VYKFG 356_ KNSSG 361_ WKEEE 366_VLQSR
1: Transcriptional activator that binds and transactivates ETS sequences containing the consensus nucleotide core sequence GGA[AT]. Acts synergistically with POU2F3 to transactivate the SPRR2A promoter and with RUNX1 to transactivate the ANGPT1 promoter. Also transactivates collagenase, CCL20, CLND7, FLG, KRT8, NOS2, PTGS2, SPRR2B, TGFBR2 and TGM3 promoters. Represses KRT4 promoter activity. Involved in mediating vascular inflammation. May play an important role in epithelial cell differentiation and tumorigenesis. May be a critical downstream effector of the ERBB2 signaling pathway. May be associated with mammary gland development and involution. Plays an important role in the regulation of transcription with TATA-less promoters in preimplantation embryos, which is essential in preimplantation development (By similarity)