Endonuclease III-like protein 1 (hNTH1) (EC 3.2.2.-) (EC 4.2.99.18) (Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase) (DNA glycosylase/AP lyase)
1_MCSPQ 6_ ESGMT 11_ ALSAR 16_ MLTRS 21_ RSLGP 26_ GAGPR 31_ GCREE 36_ PGPLR 41_ RREAA 46_ AEARK 51_ SHSPV 56_ KRPRK 61_ AQRLR 66_ VAYEG 71_ SDSEK 76_ GEGAE 81_ PLKVP 86_ VWEPQ 91_ DWQQQ 96_ LVNIR 101_ AMRNK 106_ KDAPV 111_ DHLGT 116_ EHCYD 121_ SSAPP 126_ KVRRY 131_ QVLLS 136_ LMLSS 141_ QTKDQ 146_ VTAGA 151_ MQRLR 156_ ARGLT 161_ VDSIL 166_ QTDDA 171_ TLGKL 176_ IYPVG 181_ FWRSK 186_ VKYIK 191_ QTSAI 196_ LQQHY 201_ GGDIP 206_ ASVAE 211_ LVALP 216_ GVGPK 221_ MAHLA 226_ MAVAW 231_ GTVSG 236_ IAVDT 241_ HVHRI 246_ ANRLR 251_ WTKKA 256_ TKSPE 261_ ETRAA 266_ LEEWL 271_ PRELW 276_ HEING 281_ LLVGF 286_ GQQTC 291_ LPVHP 296_ RCHAC 301_ LNQAL 306_CPAAQ
1: Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage (PubMed:29610152, PubMed:9927729). The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. Also has 8-oxo-7,8-dihydroguanine (8-oxoG) DNA glycosylase activity. Acts preferentially on DNA damage opposite guanine residues in DNA. Is able to process lesions in nucleosomes without requiring or inducing nucleosome disruption