Death domain-containing protein CRADD (Caspase and RIP adapter with death domain) (RIP-associated protein with a death domain)
1_MEARD 6_ KQVLR 11_ SLRLE 16_ LGAEV 21_ LVEGL 26_ VLQYL 31_ YQEGI 36_ LTENH 41_ IQEIN 46_ AQTTG 51_ LRKTM 56_ LLLDI 61_ LPSRG 66_ PKAFD 71_ TFLDS 76_ LQEFP 81_ WVREK 86_ LKKAR 91_ EEAMT 96_ DLPAG 101_ DRLTG 106_ IPSHI 111_ LNSSP 116_ SDRQI 121_ NQLAQ 126_ RLGPE 131_ WEPMV 136_ LSLGL 141_ SQTDI 146_ YRCKA 151_ NHPHN 156_ VQSQV 161_ VEAFI 166_ RWRQR 171_ FGKQA 176_ TFQSL 181_ HNGLR 186_ AVEVD 191_PSLLL
1: Adapter protein that associates with PIDD1 and the caspase CASP2 to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis (PubMed:15073321, PubMed:16652156, PubMed:17159900, PubMed:17289572, PubMed:9044836). Also recruits CASP2 to the TNFR-1 signaling complex through its interaction with RIPK1 and TRADD and may play a role in the tumor necrosis factor-mediated signaling pathway (PubMed:8985253)