Phosphate-regulating neutral endopeptidase PHEX (EC 3.4.24.-) (Metalloendopeptidase homolog PEX) (Vitamin D-resistant hypophosphatemic rickets protein) (X-linked hypophosphatemia protein) (HYP)
1_MEAET 6_ GSSVE 11_ TGKKA 16_ NRGTR 21_ IALVV 26_ FVGGT 31_ LVLGT 36_ ILFLV 41_ SQGLL 46_ SLQAK 51_ QEYCL 56_ KPECI 61_ EAAAA 66_ ILSKV 71_ NLSVD 76_ PCDNF 81_ FRFAC 86_ DGWIS 91_ NNPIP 96_ EDMPS 101_ YGVYP 106_ WLRHN 111_ VDLKL 116_ KELLE 121_ KSISR 126_ RRDTE 131_ AIQKA 136_ KILYS 141_ SCMNE 146_ KAIEK 151_ ADAKP 156_ LLHIL 161_ RHSPF 166_ RWPVL 171_ ESNIG 176_ PEGVW 181_ SERKF 186_ SLLQT 191_ LATFR 196_ GQYSN 201_ SVFIR 206_ LYVSP 211_ DDKAS 216_ NEHIL 221_ KLDQA 226_ TLSLA 231_ VREDY 236_ LDNST 241_ EAKSY 246_ RDALY 251_ KFMVD 256_ TAVLL 261_ GANSS 266_ RAEHD 271_ MKSVL 276_ RLEIK 281_ IAEIM 286_ IPHEN 291_ RTSEA 296_ MYNKM 301_ NISEL 306_ SAMIP 311_ QFDWL 316_ GYIKK 321_ VIDTR 326_ LYPHL 331_ KDISP 336_ SENVV 341_ VRVPQ 346_ YFKDL 351_ FRILG 356_ SERKK 361_ TIANY 366_ LVWRM 371_ VYSRI 376_ PNLSR 381_ RFQYR 386_ WLEFS 391_ RVIQG 396_ TTTLL 401_ PQWDK 406_ CVNFI 411_ ESALP 416_ YVVGK 421_ MFVDV 426_ YFQED 431_ KKEMM 436_ EELVE 441_ GVRWA 446_ FIDML 451_ EKENE 456_ WMDAG 461_ TKRKA 466_ KEKAR 471_ AVLAK 476_ VGYPE 481_ FIMND 486_ THVNE 491_ DLKAI 496_ KFSEA 501_ DYFGN 506_ VLQTR 511_ KYLAQ 516_ SDFFW 521_ LRKAV 526_ PKTEW 531_ FTNPT 536_ TVNAF 541_ YSAST 546_ NQIRF 551_ PAGEL 556_ QKPFF 561_ WGTEY 566_ PRSLS 571_ YGAIG 576_ VIVGH 581_ EFTHG 586_ FDNNG 591_ RKYDK 596_ NGNLD 601_ PWWST 606_ ESEEK 611_ FKEKT 616_ KCMIN 621_ QYSNY 626_ YWKKA 631_ GLNVK 636_ GKRTL 641_ GENIA 646_ DNGGL 651_ REAFR 656_ AYRKW 661_ INDRR 666_ QGLEE 671_ PLLPG 676_ ITFTN 681_ NQLFF 686_ LSYAH 691_ VRCNS 696_ YRPEA 701_ AREQV 706_ QIGAH 711_ SPPQF 716_ RVNGA 721_ ISNFE 726_ EFQKA 731_ FNCPP 736_ NSTMN 741_RGMDS
1: Peptidase that cleaves SIBLING (small integrin-binding ligand, N-linked glycoprotein)-derived ASARM peptides, thus regulating their biological activity (PubMed:15664000, PubMed:18162525, PubMed:18597632, PubMed:9593714). Cleaves ASARM peptides between Ser and Glu or Asp residues (PubMed:18597632). Regulates osteogenic cell differentiation and bone mineralization through the cleavage of the MEPE-derived ASARM peptide (PubMed:18597632). Promotes dentin mineralization and renal phosphate reabsorption by cleaving DMP1- and MEPE-derived ASARM peptides (PubMed:18162525, PubMed:18597632). Inhibits the cleavage of MEPE by CTSB/cathepsin B thus preventing MEPE degradation (PubMed:12220505)