Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1)
1_MEPSR 6_ ALLGC 11_ LASAA 16_ AAAPP 21_ GEDGA 26_ GAGAE 31_ EEEEE 36_ EEEAA 41_ AAVGP 46_ GELGC 51_ DAPLP 56_ YWTAV 61_ FEYEA 66_ AGEDE 71_ LTLRL 76_ GDVVE 81_ VLSKD 86_ SQVSG 91_ DEGWW 96_ TGQLN 101_ QRVGI 106_ FPSNY 111_ VTPRS 116_ AFSSR 121_ CQPGG 126_ EDPSC 131_ YPPIQ 136_ LLEID 141_ FAELT 146_ LEEII 151_ GIGGF 156_ GKVYR 161_ AFWIG 166_ DEVAV 171_ KAARH 176_ DPDED 181_ ISQTI 186_ ENVRQ 191_ EAKLF 196_ AMLKH 201_ PNIIA 206_ LRGVC 211_ LKEPN 216_ LCLVM 221_ EFARG 226_ GPLNR 231_ VLSGK 236_ RIPPD 241_ ILVNW 246_ AVQIA 251_ RGMNY 256_ LHDEA 261_ IVPII 266_ HRDLK 271_ SSNIL 276_ ILQKV 281_ ENGDL 286_ SNKIL 291_ KITDF 296_ GLARE 301_ WHRTT 306_ KMSAA 311_ GTYAW 316_ MAPEV 321_ IRASM 326_ FSKGS 331_ DVWSY 336_ GVLLW 341_ ELLTG 346_ EVPFR 351_ GIDGL 356_ AVAYG 361_ VAMNK 366_ LALPI 371_ PSTCP 376_ EPFAK 381_ LMEDC 386_ WNPDP 391_ HSRPS 396_ FTNIL 401_ DQLTT 406_ IEESG 411_ FFEMP 416_ KDSFH 421_ CLQDN 426_ WKHEI 431_ QEMFD 436_ QLRAK 441_ EKELR 446_ TWEEE 451_ LTRAA 456_ LQQKN 461_ QEELL 466_ RRREQ 471_ ELAER 476_ EIDIL 481_ ERELN 486_ IIIHQ 491_ LCQEK 496_ PRVKK 501_ RKGKF 506_ RKSRL 511_ KLKDG 516_ NRISL 521_ PSDFQ 526_ HKFTV 531_ QASPT 536_ MDKRK 541_ SLINS 546_ RSSPP 551_ ASPTI 556_ IPRLR 561_ AIQLT 566_ PGESS 571_ KTWGR 576_ SSVVP 581_ KEEGE 586_ EEEKR 591_ APKKK 596_ GRTWG 601_ PGTLG 606_ QKELA 611_ SGDEG 616_ SPQRR 621_ EKANG 626_ LSTPS 631_ ESPHF 636_ HLGLK 641_ SLVDG 646_ YKQWS 651_ SSAPN 656_ LVKGP 661_ RSSPA 666_ LPGFT 671_ SLMEM 676_ EDEDS 681_ EGPGS 686_ GESRL 691_ QHSPS 696_ QSYLC 701_ IPFPR 706_ GEDGD 711_ GPSSD 716_ GIHEE 721_ PTPVN 726_ SATST 731_ PQLTP 736_ TNSLK 741_ RGGAH 746_ HRRCE 751_ VALLG 756_ CGAVL 761_ AATGL 766_ GFDLL 771_ EAGKC 776_ QLLPL 781_ EEPEP 786_ PAREE 791_ KKRRE 796_ GLFQR 801_ SSRPR 806_ RSTSP 811_ PSRKL 816_ FKKEE 821_ PMLLL 826_ GDPSA 831_ SLTLL 836_ SLSSI 841_ SECNS 846_ TRSLL 851_ RSDSD 856_ EIVVY 861_ EMPVS 866_ PVEAP 871_ PLSPC 876_ THNPL 881_ VNVRV 886_ ERFKR 891_ DPNQS 896_ LTPTH 901_ VTLTT 906_ PSQPS 911_ SHRRT 916_ PSDGA 921_ LKPET 926_ LLASR 931_ SPSSN 936_ GLSPS 941_ PGAGM 946_ LKTPS 951_ PSRDP 956_ GEFPR 961_ LPDPN 966_ VVFPP 971_ TPRRW 976_ NTQQD 981_ STLER 986_ PKTLE 991_ FLPRP 996_ RPSAN 1001_ RQRLD 1006_ PWWFV 1011_ SPSHA 1016_ RSTSP 1021_ ANSSS 1026_ TETPS 1031_ NLDSC 1036_ FASSS 1041_ STVEE 1046_ RPGLP 1051_ ALLPF 1056_ QAGPL 1061_ PPTER 1066_ TLLDL 1071_ DAEGQ 1076_ SQDST 1081_ VPLCR 1086_ AELNT 1091_ HRPAP 1096_YEIQQ
1: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade through the phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7 which in turn activate the JNKs. The MKK/JNK signaling pathway regulates stress response via activator protein-1 (JUN) and GATA4 transcription factors. Also plays a role in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis