Interferon-induced 35 kDa protein (IFP 35) (Ifi-35)
1_MSAPL 6_ DAALH 11_ ALQEE 16_ QARLK 21_ MRLWD 26_ LQQLR 31_ KELGD 36_ SPKDK 41_ VPFSV 46_ PKIPL 51_ VFRGH 56_ TQQDP 61_ EVPKS 66_ LVSNL 71_ RIHCP 76_ LLAGS 81_ ALITF 86_ DDPKV 91_ AEQVL 96_ QQKEH 101_ TINME 106_ ECRLR 111_ VQVQP 116_ LELPM 121_ VTTIQ 126_ MSSQL 131_ SGRRV 136_ LVTGF 141_ PASLR 146_ LSEEE 151_ LLDKL 156_ EIFFG 161_ KTRNG 166_ GGDVD 171_ VRELL 176_ PGSVM 181_ LGFAR 186_ DGVAQ 191_ RLCQI 196_ GQFTV 201_ PLGGQ 206_ QVPLR 211_ VSPYV 216_ NGEIQ 221_ KAEIR 226_ SQPVP 231_ RSVLV 236_ LNIPD 241_ ILDGP 246_ ELHDV 251_ LEIHF 256_ QKPTR 261_ GGGEV 266_ EALTV 271_ VPQGQ 276_ QGLAV 281_FTSES
1: Acts as a signaling pathway regulator involved in innate immune system response (PubMed:26342464, PubMed:29038465, PubMed:29350881). In response to interferon IFN-alpha, associates in a complex with signaling pathway regulator NMI to regulate immune response; the complex formation prevents proteasome-mediated degradation of IFI35 and correlates with IFI35 dephosphorylation (PubMed:10779520, PubMed:10950963). In complex with NMI, inhibits virus-triggered type I interferon/IFN-beta production (PubMed:26342464). In complex with NMI, negatively regulates nuclear factor NF-kappa-B signaling by inhibiting the nuclear translocation, activation and transcription of the NF-kappa-B subunit p65/RELA, resulting in the inhibition of endothelial cell proliferation, migration and re-endothelialization of injured arteries (PubMed:29350881). Beside its role as an intracellular signaling pathway regulator, also functions extracellularly as damage-associated molecular patterns (DAMPs) to promote inflammation when actively released by macrophage to the extracellular space during cell injury and pathogen invasion (PubMed:29038465). Macrophage-secreted IFI35 activates NF-kappa-B signaling in adjacent macrophages through Toll-like receptor 4/TLR4 activation, thereby inducing NF-kappa-B translocation from the cytoplasm into the nucleus which promotes the release of pro-inflammatory cytokines (PubMed:29038465)