Nucleobindin-2 (DNA-binding protein NEFA) (Epididymis secretory protein Li 109) (Gastric cancer antigen Zg4) (Prepronesfatin) [Cleaved into: Nesfatin-1]
1_MRWRT 6_ ILLQY 11_ CFLLI 16_ TCLLT 21_ ALEAV 26_ PIDID 31_ KTKVQ 36_ NIHPV 41_ ESAKI 46_ EPPDT 51_ GLYYD 56_ EYLKQ 61_ VIDVL 66_ ETDKH 71_ FREKL 76_ QKADI 81_ EEIKS 86_ GRLSK 91_ ELDLV 96_ SHHVR 101_ TKLDE 106_ LKRQE 111_ VGRLR 116_ MLIKA 121_ KLDSL 126_ QDIGM 131_ DHQAL 136_ LKQFD 141_ HLNHL 146_ NPDKF 151_ ESTDL 156_ DMLIK 161_ AATSD 166_ LEHYD 171_ KTRHE 176_ EFKKY 181_ EMMKE 186_ HERRE 191_ YLKTL 196_ NEEKR 201_ KEEES 206_ KFEEM 211_ KKKHE 216_ NHPKV 221_ NHPGS 226_ KDQLK 231_ EVWEE 236_ TDGLD 241_ PNDFD 246_ PKTFF 251_ KLHDV 256_ NSDGF 261_ LDEQE 266_ LEALF 271_ TKELE 276_ KVYDP 281_ KNEED 286_ DMVEM 291_ EEERL 296_ RMREH 301_ VMNEV 306_ DTNKD 311_ RLVTL 316_ EEFLK 321_ ATEKK 326_ EFLEP 331_ DSWET 336_ LDQQQ 341_ FFTEE 346_ ELKEY 351_ ENIIA 356_ LQENE 361_ LKKKA 366_ DELQK 371_ QKEEL 376_ QRQHD 381_ QLEAQ 386_ KLEYH 391_ QVIQQ 396_ MEQKK 401_ LQQGI 406_ PPSGP 411_AGELK
1: Calcium-binding protein which may have a role in calcium homeostasis (By similarity). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates guanine nucleotide-binding protein (G-protein) alpha subunit GNAI3 (By similarity)
2: Anorexigenic peptide, seems to play an important role in hypothalamic pathways regulating food intake and energy homeostasis, acting in a leptin-independent manner. May also exert hypertensive roles and modulate blood pressure through directly acting on peripheral arterial resistance. In intestinal epithelial cells, plays a role in the inhibition of hepatic glucose production via MC4R receptor leading to increased cyclic adenosine monophosphate (cAMP) levels and glucagon-like peptide 1 (GLP-1) secretion (PubMed:39562740)