G-protein-signaling modulator 2 (Mosaic protein LGN)
1_MEENL 6_ ISMRE 11_ DHSFH 16_ VRYRM 21_ EASCL 26_ ELALE 31_ GERLC 36_ KSGDC 41_ RAGVS 46_ FFEAA 51_ VQVGT 56_ EDLKT 61_ LSAIY 66_ SQLGN 71_ AYFYL 76_ HDYAK 81_ ALEYH 86_ HHDLT 91_ LARTI 96_ GDQLG 101_ EAKAS 106_ GNLGN 111_ TLKVL 116_ GNFDE 121_ AIVCC 126_ QRHLD 131_ ISREL 136_ NDKVG 141_ EARAL 146_ YNLGN 151_ VYHAK 156_ GKSFG 161_ CPGPQ 166_ DVGEF 171_ PEEVR 176_ DALQA 181_ AVDFY 186_ EENLS 191_ LVTAL 196_ GDRAA 201_ QGRAF 206_ GNLGN 211_ THYLL 216_ GNFRD 221_ AVIAH 226_ EQRLL 231_ IAKEF 236_ GDKAA 241_ ERRAY 246_ SNLGN 251_ AYIFL 256_ GEFET 261_ ASEYY 266_ KKTLL 271_ LARQL 276_ KDRAV 281_ EAQSC 286_ YSLGN 291_ TYTLL 296_ QDYEK 301_ AIDYH 306_ LKHLA 311_ IAQEL 316_ NDRIG 321_ EGRAC 326_ WSLGN 331_ AYTAL 336_ GNHDQ 341_ AMHFA 346_ EKHLE 351_ ISREV 356_ GDKSG 361_ ELTAR 366_ LNLSD 371_ LQMVL 376_ GLSYS 381_ TNNSI 386_ MSENT 391_ EIDSS 396_ LNGVR 401_ PKLGR 406_ RHSME 411_ NMELM 416_ KLTPE 421_ KVQNW 426_ NSEIL 431_ AKQKP 436_ LIAKP 441_ SAKLL 446_ FVNRL 451_ KGKKY 456_ KTNSS 461_ TKVLQ 466_ DASNS 471_ IDHRI 476_ PNSQR 481_ KISAD 486_ TIGDE 491_ GFFDL 496_ LSRFQ 501_ SNRMD 506_ DQRCC 511_ LQEKN 516_ CHTAS 521_ TTTSS 526_ TPPKM 531_ MLKTS 536_ SVPVV 541_ SPNTD 546_ EFLDL 551_ LASSQ 556_ SRRLD 561_ DQRAS 566_ FSNLP 571_ GLRLT 576_ QNSQS 581_ VLSHL 586_ MTNDN 591_ KEADE 596_ DFFDI 601_ LVKCQ 606_ GSRLD 611_ DQRCA 616_ PPPAT 621_ TKGPT 626_ VPDED 631_ FFSLI 636_ LRSQG 641_ KRMDE 646_ QRVLL 651_ QRDQN 656_ RDTDF 661_ GLKDF 666_ LQNNA 671_ LLEFK 676_NSGKK
1: Plays an important role in mitotic spindle pole organization via its interaction with NUMA1 (PubMed:11781568, PubMed:15632202, PubMed:21816348). Required for cortical dynein-dynactin complex recruitment during metaphase (PubMed:22327364). Plays a role in metaphase spindle orientation (PubMed:22327364). Also plays an important role in asymmetric cell divisions (PubMed:21816348). Has guanine nucleotide dissociation inhibitor (GDI) activity towards G(i) alpha proteins, such as GNAI1 and GNAI3, and thereby regulates their activity (By similarity)