b(0,+)-type amino acid transporter 1 (b(0,+)AT1) (Glycoprotein-associated amino acid transporter b0,+AT1) (Solute carrier family 7 member 9)
1_MGDTG 6_ LRKRR 11_ EDEKS 16_ IQSQE 21_ PKTTS 26_ LQKEL 31_ GLISG 36_ ISIIV 41_ GTIIG 46_ SGIFV 51_ SPKSV 56_ LSNTE 61_ AVGPC 66_ LIIWA 71_ ACGVL 76_ ATLGA 81_ LCFAE 86_ LGTMI 91_ TKSGG 96_ EYPYL 101_ MEAYG 106_ PIPAY 111_ LFSWA 116_ SLIVI 121_ KPTSF 126_ AIICL 131_ SFSEY 136_ VCAPF 141_ YVGCK 146_ PPQIV 151_ VKCLA 156_ AAAIL 161_ FISTV 166_ NSLSV 171_ RLGSY 176_ VQNIF 181_ TAAKL 186_ VIVAI 191_ IIISG 196_ LVLLA 201_ QGNTK 206_ NFDNS 211_ FEGAQ 216_ LSVGA 221_ ISLAF 226_ YNGLW 231_ AYDGW 236_ NQLNY 241_ ITEEL 246_ RNPYR 251_ NLPLA 256_ IIIGI 261_ PLVTA 266_ CYILM 271_ NVSYF 276_ TVMTA 281_ TELLQ 286_ SQAVA 291_ VTFGD 296_ RVLYP 301_ ASWIV 306_ PLFVA 311_ FSTIG 316_ AANGT 321_ CFTAG 326_ RLIYV 331_ AGREG 336_ HMLKV 341_ LSYIS 346_ VRRLT 351_ PAPAI 356_ IFYGI 361_ IATIY 366_ IIPGD 371_ INSLV 376_ NYFSF 381_ AAWLF 386_ YGLTI 391_ LGLIV 396_ MRFTR 401_ KELER 406_ PIKVP 411_ VVIPV 416_ LMTLI 421_ SVFLV 426_ LAPII 431_ SKPTW 436_ EYLYC 441_ VLFIL 446_ SGLLF 451_ YFLFV 456_ HYKFG 461_ WAQKI 466_ SKPIT 471_ MHLQM 476_ LMEVV 481_PPEED
1: Associates with SLC3A1 to form a functional transporter complex that mediates the electrogenic exchange between cationic amino acids and neutral amino acids, with a stoichiometry of 1:1 (PubMed:16825196, PubMed:32494597, PubMed:32817565, PubMed:8663357). Has system b(0,+)-like activity with high affinity for extracellular cationic amino acids and L-cystine and lower affinity for intracellular neutral amino acids (PubMed:16825196, PubMed:32494597, PubMed:8663357). Substrate exchange is driven by high concentration of intracellular neutral amino acids and the intracellular reduction of L-cystine to L-cysteine (PubMed:8663357). Required for reabsorption of L-cystine and dibasic amino acids across the brush border membrane in renal proximal tubules