SAP domain-containing ribonucleoprotein (Cytokine-induced protein of 29 kDa) (Nuclear protein Hcc-1) (Proliferation-associated cytokine-inducible protein CIP29)
1_MATET 6_ VELHK 11_ LKLAE 16_ LKQEC 21_ LARGL 26_ ETKGI 31_ KQDLI 36_ HRLQA 41_ YLEEH 46_ AEEEA 51_ NEEDV 56_ LGDET 61_ EEEET 66_ KPIEL 71_ PVKEE 76_ EPPEK 81_ TVDVA 86_ AEKKV 91_ VKITS 96_ EIPQT 101_ ERMQK 106_ RAERF 111_ NVPVS 116_ LESKK 121_ AARAA 126_ RFGIS 131_ SVPTK 136_ GLSSD 141_ NKPMV 146_ NLDKL 151_ KERAQ 156_ RFGLN 161_ VSSIS 166_ RKSED 171_ DEKLK 176_ KRKER 181_ FGIVT 186_ SSAGT 191_ GTTED 196_ TEAKK 201_RKRAE
1: Binds both single-stranded and double-stranded DNA with higher affinity for the single-stranded form. Specifically binds to scaffold/matrix attachment region DNA. Also binds single-stranded RNA. Enhances RNA unwinding activity of DDX39A. May participate in important transcriptional or translational control of cell growth, metabolism and carcinogenesis. Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA (PubMed:15338056, PubMed:17196963, PubMed:20844015). The TREX complex is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway (PubMed:15338056, PubMed:17196963, PubMed:20844015). Associates with DDX39B, which facilitates RNA binding of DDX39B and likely plays a role in mRNA export (PubMed:37578863)