Serine protease HTRA3 (EC 3.4.21.-) (High-temperature requirement factor A3) (Pregnancy-related serine protease)
1_MQARA 6_ LLLAA 11_ LAALA 16_ LAREP 21_ PAAPC 26_ PARCD 31_ VSRCP 36_ SPRCP 41_ GGYVP 46_ DLCNC 51_ CLVCA 56_ ASEGE 61_ PCGGP 66_ LDSPC 71_ GESLE 76_ CVRGL 81_ CRCRW 86_ SHAVC 91_ GTDGH 96_ TYANV 101_ CALQA 106_ ASRRA 111_ LQLSG 116_ TPVRQ 121_ LQKGA 126_ CPLGL 131_ HQLSS 136_ PRYKF 141_ NFIAD 146_ VVEKI 151_ APAVV 156_ HIELF 161_ LRHPL 166_ FGRNV 171_ PLSSG 176_ SGFIM 181_ SEAGL 186_ IITNA 191_ HVVSS 196_ NSAAP 201_ GRQQL 206_ KVQLQ 211_ NGDSY 216_ EATIK 221_ DIDKK 226_ SDIAT 231_ IKIHP 236_ KKKLP 241_ VLLLG 246_ HSADL 251_ RPGEF 256_ VVAIG 261_ SPFAL 266_ QNTVT 271_ TGIVS 276_ TAQRE 281_ GRELG 286_ LRDSD 291_ MDYIQ 296_ TDAII 301_ NYGNS 306_ GGPLV 311_ NLDGE 316_ VIGIN 321_ TLKVT 326_ AGISF 331_ AIPSD 336_ RITRF 341_ LTEFQ 346_ DKQIK 351_ DWKKR 356_ FIGIR 361_ MRTIT 366_ PSLVD 371_ ELKAS 376_ NPDFP 381_ EVSSG 386_ IYVQE 391_ VAPNS 396_ PSQRG 401_ GIQDG 406_ DIIVK 411_ VNGRP 416_ LVDSS 421_ ELQEA 426_ VLTES 431_ PLLLE 436_ VRRGN 441_ DDLLF 446_SIAPE
1: Serine protease that cleaves beta-casein/CSN2 as well as several extracellular matrix (ECM) proteoglycans such as decorin/DCN, biglycan/BGN and fibronectin/FN1. Inhibits signaling mediated by TGF-beta family proteins possibly indirectly by degradation of these ECM proteoglycans (By similarity). May act as a tumor suppressor. Negatively regulates, in vitro, trophoblast invasion during placental development and may be involved in the development of the placenta in vivo. May also have a role in ovarian development, granulosa cell differentiation and luteinization (PubMed:21321049, PubMed:22229724)