Serine beta-lactamase-like protein LACTB, mitochondrial (EC 3.4.-.-)
1_MYRLM 6_ SAVTA 11_ RAAAP 16_ GGLAS 21_ SCGRR 26_ GVHQR 31_ AGLPP 36_ LGHGW 41_ VGGLG 46_ LGLGL 51_ ALGVK 56_ LAGGL 61_ RGAAP 66_ AQSPA 71_ APDPE 76_ ASPLA 81_ EPPQE 86_ QSLAP 91_ WSPQT 96_ PAPPC 101_ SRCFA 106_ RAIES 111_ SRDLL 116_ HRIKD 121_ EVGAP 126_ GIVVG 131_ VSVDG 136_ KEVWS 141_ EGLGY 146_ ADVEN 151_ RVPCK 156_ PETVM 161_ RIASI 166_ SKSLT 171_ MVALA 176_ KLWEA 181_ GKLDL 186_ DIPVQ 191_ HYVPE 196_ FPEKE 201_ YEGEK 206_ VSVTT 211_ RLLIS 216_ HLSGI 221_ RHYEK 226_ DIKKV 231_ KEEKA 236_ YKALK 241_ MMKEN 246_ VAFEQ 251_ EKEGK 256_ SNEKN 261_ DFTKF 266_ KTEQE 271_ NEAKC 276_ RNSKP 281_ GKKKN 286_ DFEQG 291_ ELYLR 296_ EKFEN 301_ SIESL 306_ RLFKN 311_ DPLFF 316_ KPGSQ 321_ FLYST 326_ FGYTL 331_ LAAIV 336_ ERASG 341_ CKYLD 346_ YMQKI 351_ FHDLD 356_ MLTTV 361_ QEENE 366_ PVIYN 371_ RARFY 376_ VYNKK 381_ KRLVN 386_ TPYVD 391_ NSYKW 396_ AGGGF 401_ LSTVG 406_ DLLKF 411_ GNAML 416_ YGYQV 421_ GLFKN 426_ SNENL 431_ LPGYL 436_ KPETM 441_ VMMWT 446_ PVPNT 451_ EMSWD 456_ KEGKY 461_ AMAWG 466_ VVERK 471_ QTYGS 476_ CRKQR 481_ HYASH 486_ TGGAV 491_ GASSV 496_ LLVLP 501_ EELDT 506_ ETINN 511_ KVPPR 516_ GIIVS 521_ IICNM 526_ QSVGL 531_ NSTAL 536_ KIALE 541_FDKDR
1: Mitochondrial serine protease that acts as a regulator of mitochondrial lipid metabolism (PubMed:28329758). Acts by decreasing protein levels of PISD, a mitochondrial enzyme that converts phosphatidylserine (PtdSer) to phosphatidylethanolamine (PtdEtn), thereby affecting mitochondrial lipid metabolism (PubMed:28329758). It is unclear whether it acts directly by mediating proteolysis of PISD or by mediating proteolysis of another lipid metabolism protein (PubMed:28329758). Acts as a tumor suppressor that has the ability to inhibit proliferation of multiple types of breast cancer cells: probably by promoting decreased levels of PISD, thereby affecting mitochondrial lipid metabolism (PubMed:28329758)