Mothers against decapentaplegic homolog 3 (MAD homolog 3) (Mad3) (Mothers against DPP homolog 3) (hMAD-3) (JV15-2) (SMAD family member 3) (SMAD 3) (Smad3) (hSMAD3)
1_MSSIL 6_ PFTPP 11_ IVKRL 16_ LGWKK 21_ GEQNG 26_ QEEKW 31_ CEKAV 36_ KSLVK 41_ KLKKT 46_ GQLDE 51_ LEKAI 56_ TTQNV 61_ NTKCI 66_ TIPRS 71_ LDGRL 76_ QVSHR 81_ KGLPH 86_ VIYCR 91_ LWRWP 96_ DLHSH 101_ HELRA 106_ MELCE 111_ FAFNM 116_ KKDEV 121_ CVNPY 126_ HYQRV 131_ ETPVL 136_ PPVLV 141_ PRHTE 146_ IPAEF 151_ PPLDD 156_ YSHSI 161_ PENTN 166_ FPAGI 171_ EPQSN 176_ IPETP 181_ PPGYL 186_ SEDGE 191_ TSDHQ 196_ MNHSM 201_ DAGSP 206_ NLSPN 211_ PMSPA 216_ HNNLD 221_ LQPVT 226_ YCEPA 231_ FWCSI 236_ SYYEL 241_ NQRVG 246_ ETFHA 251_ SQPSM 256_ TVDGF 261_ TDPSN 266_ SERFC 271_ LGLLS 276_ NVNRN 281_ AAVEL 286_ TRRHI 291_ GRGVR 296_ LYYIG 301_ GEVFA 306_ ECLSD 311_ SAIFV 316_ QSPNC 321_ NQRYG 326_ WHPAT 331_ VCKIP 336_ PGCNL 341_ KIFNN 346_ QEFAA 351_ LLAQS 356_ VNQGF 361_ EAVYQ 366_ LTRMC 371_ TIRMS 376_ FVKGW 381_ GAEYR 386_ RQTVT 391_ STPCW 396_ IELHL 401_ NGPLQ 406_ WLDKV 411_ LTQMG 416_SPSIR
1: Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator