ADP-ribosylation factor 1
1_MGNIF 6_ ANLFK 11_ GLFGK 16_ KEMRI 21_ LMVGL 26_ DAAGK 31_ TTILY 36_ KLKLG 41_ EIVTT 46_ IPTIG 51_ FNVET 56_ VEYKN 61_ ISFTV 66_ WDVGG 71_ QDKIR 76_ PLWRH 81_ YFQNT 86_ QGLIF 91_ VVDSN 96_ DRERV 101_ NEARE 106_ ELMRM 111_ LAEDE 116_ LRDAV 121_ LLVFA 126_ NKQDL 131_ PNAMN 136_ AAEIT 141_ DKLGL 146_ HSLRH 151_ RNWYI 156_ QATCA 161_ TSGDG 166_ LYEGL 171_ DWLSN 176_QLRNQ
1: Small GTPase involved in protein trafficking between different compartments (PubMed:8253837). Modulates vesicle budding and uncoating within the Golgi complex (PubMed:8253837). In its GTP-bound form, triggers the recruitment of coatomer proteins to the Golgi membrane (PubMed:8253837). The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles (PubMed:8253837). The GTP-bound form interacts with PICK1 to limit PICK1-mediated inhibition of Arp2/3 complex activity; the function is linked to AMPA receptor (AMPAR) trafficking, regulation of synaptic plasticity of excitatory synapses and spine shrinkage during long-term depression (LTD) (By similarity). Plays a key role in the regulation of intestinal stem cells and gut microbiota, and is essential for maintaining intestinal homeostasis (By similarity). Also plays a critical role in mast cell expansion but not in mast cell maturation by facilitating optimal mTORC1 activation (By similarity)
2: (Microbial infection) Functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase