Rho-related GTP-binding protein RhoG
1_MQSIK 6_ CVVVG 11_ DGAVG 16_ KTCLL 21_ ICYTT 26_ NAFPK 31_ EYIPT 36_ VFDNY 41_ SAQSA 46_ VDGRT 51_ VNLNL 56_ WDTAG 61_ QEEYD 66_ RLRTL 71_ SYPQT 76_ NVFVI 81_ CFSIA 86_ SPPSY 91_ ENVRH 96_ KWHPE 101_ VCHHC 106_ PDVPI 111_ LLVGT 116_ KKDLR 121_ AQPDT 126_ LRRLK 131_ EQGQA 136_ PITPQ 141_ QGQAL 146_ AKQIH 151_ AVRYL 156_ ECSAL 161_ QQDGV 166_ KEVFA 171_ EAVRA 176_ VLNPT 181_ PIKRG 186_RSCIL
1: Plays a role in immunological synaptic F-actin density and architecture organization (PubMed:33513601). Regulates actin reorganization in lymphocytes, possibly through the modulation of Rac1 activity (PubMed:33513601). Required for the formation of membrane ruffles during macropinocytosis (PubMed:15133129). Plays a role in cell migration and is required for the formation of cup-like structures during trans-endothelial migration of leukocytes (PubMed:17875742). Binds phospholipids in an activation-dependent manner; thereby acting as an anchor for other proteins to the plasma membrane (PM) (PubMed:33513601). Plays a role in exocytosis of cytotoxic granules (CG) by lymphocytes/Component of the exocytosis machinery in natural killer (NK) and CD8+ T cells (PubMed:33513601). Promotes the docking of cytotoxic granules (CG) to the plasma membrane through the interaction with UNC13D (PubMed:33513601). Involved in the cytotoxic activity of lymphocytes/primary CD8+ T cells (PubMed:33513601)
2: (Microbial infection) In case of Salmonella enterica infection, activated by SopB and ARHGEF26/SGEF, which induces cytoskeleton rearrangements and promotes bacterial entry