Serine/arginine-rich splicing factor 3 (Pre-mRNA-splicing factor SRP20) (Splicing factor, arginine/serine-rich 3)
1_MHRDS 6_ CPLDC 11_ KVYVG 16_ NLGNN 21_ GNKTE 26_ LERAF 31_ GYYGP 36_ LRSVW 41_ VARNP 46_ PGFAF 51_ VEFED 56_ PRDAA 61_ DAVRE 66_ LDGRT 71_ LCGCR 76_ VRVEL 81_ SNGEK 86_ RSRNR 91_ GPPPS 96_ WGRRP 101_ RDDYR 106_ RRSPP 111_ PRRRS 116_ PRRRS 121_ FSRSR 126_ SRSLS 131_ RDRRR 136_ ERSLS 141_ RERNH 146_ KPSRS 151_ FSRSR 156_SRSRS
1: Splicing factor, which binds the consensus motif 5'-C[ACU][AU]C[ACU][AC]C-3' within pre-mRNA and promotes specific exons inclusion during alternative splicing (PubMed:17036044, PubMed:26876937, PubMed:32440474). Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites within exons (PubMed:26876937). Also functions as an adapter involved in mRNA nuclear export (PubMed:11336712, PubMed:18364396, PubMed:28984244). Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity (PubMed:11336712, PubMed:18364396). Involved in nuclear export of m6A-containing mRNAs via interaction with YTHDC1: interaction with YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export (PubMed:28984244)