Proline-rich protein 5 (Protein observed with Rictor-1) (Protor-1)
1_MRTLR 6_ RLKFM 11_ SSPSL 16_ SDLGK 21_ REPAA 26_ AADER 31_ GTQQR 36_ RACAN 41_ ATWNS 46_ IHNGV 51_ IAVFQ 56_ RKGLP 61_ DQELF 66_ SLNEG 71_ VRQLL 76_ KTELG 81_ SFFTE 86_ YLQNQ 91_ LLTKG 96_ MVILR 101_ DKIRF 106_ YEGQK 111_ LLDSL 116_ AETWD 121_ FFFSD 126_ VLPML 131_ QAIFY 136_ PVQGK 141_ EPSVR 146_ QLALL 151_ HFRNA 156_ ITLSV 161_ KLEDA 166_ LARAH 171_ ARVPP 176_ AIVQM 181_ LLVLQ 186_ GVHES 191_ RGVTE 196_ DYLRL 201_ ETLVQ 206_ KVVSP 211_ YLGTY 216_ GLHSS 221_ EGPFT 226_ HSCIL 231_ EKRLL 236_ RRSRS 241_ GDVLA 246_ KNPVV 251_ RSKSY 256_ NTPLL 261_ NPVQE 266_ HEAEG 271_ AAAGG 276_ TSIRR 281_ HSVSE 286_ MTSCP 291_ EPQGF 296_ SDPPG 301_ QGPTG 306_ TFRSS 311_ PAPHS 316_ GPCPS 321_ RLYPT 326_ TQPPE 331_ QGLDP 336_ TRSSL 341_ PRSSP 346_ ENLVD 351_ QILES 356_ VDSDS 361_ EGIFI 366_ DFGRG 371_ RGSGM 376_ SDLEG 381_SGGRQ
1: Associated subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals (PubMed:17461779, PubMed:17599906, PubMed:29424687). mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive (PubMed:17461779, PubMed:17599906, PubMed:29424687). mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors (PubMed:17461779, PubMed:17599906, PubMed:29424687). PRR5 plays an important role in regulation of PDGFRB expression and in modulation of platelet-derived growth factor signaling (PubMed:17599906). May act as a tumor suppressor in breast cancer (PubMed:15718101)