Zinc finger BED domain-containing protein 6
1_MSVCT 6_ LSVPV 11_ SSLSP 16_ GRRCN 21_ TFSDS 26_ GILGC 31_ VPINS 36_ NTDEE 41_ DVVEE 46_ KMVAE 51_ GVNKE 56_ AKQPA 61_ KKKRK 66_ KGLRI 71_ KGKRR 76_ RKKLI 81_ LAKKF 86_ SKDLG 91_ SGRPV 96_ ADAPA 101_ LLASN 106_ DPEQD 111_ EESLF 116_ ESNIE 121_ KQIYL 126_ PSTRA 131_ KTSIV 136_ WHFFH 141_ VDPQY 146_ TWRAI 151_ CNLCE 156_ KSVSR 161_ GKPGS 166_ HLGTS 171_ TLQRH 176_ LQARH 181_ SPHWT 186_ RANKF 191_ GVASG 196_ EEDFT 201_ LDVSL 206_ SPSSG 211_ SNGSF 216_ EYIPT 221_ DPLDD 226_ NRMGK 231_ KHDKS 236_ ASDAL 241_ RAERG 246_ RFLIK 251_ SNIVK 256_ HALIP 261_ GTRAK 266_ TSAVW 271_ NFFYT 276_ DPQHI 281_ SRAVC 286_ NICKR 291_ SVSRG 296_ RPGSH 301_ LGTST 306_ LQRHL 311_ QATHP 316_ IHWAV 321_ ANKDS 326_ GAVAN 331_ GLDEA 336_ ETERS 341_ DLLSD 346_ TLHGE 351_ KSTGS 356_ QDLTA 361_ EDLSD 366_ SDSDE 371_ PMLEV 376_ ENRSE 381_ SPIPV 386_ AEQGT 391_ LMRAQ 396_ ERETT 401_ CCGNP 406_ VSSHI 411_ SQAII 416_ QMIVE 421_ DMHPY 426_ NYFST 431_ PAFQR 436_ FMQIV 441_ APDYR 446_ LPSET 451_ YFFTK 456_ AVPQL 461_ YDCVR 466_ EKIFL 471_ TLENV 476_ QSQKI 481_ HLTVD 486_ IWTHD 491_ PSTDY 496_ FIVTV 501_ HWVSL 506_ ETASF 511_ LNNGR 516_ IPDFR 521_ KWAVL 526_ CVTGL 531_ AKDCL 536_ ITNIL 541_ QELND 546_ QIGLW 551_ LSPNF 556_ LIPSF 561_ IVSDN 566_ SSNVV 571_ HAIKD 576_ GGFTH 581_ VPCFL 586_ HCLNM 591_ VIQDF 596_ FCEHK 601_ SIENM 606_ LVAAR 611_ KTCHH 616_ FSHSV 621_ KARQI 626_ LQEFQ 631_ NDHQL 636_ PWKNL 641_ KQDET 646_ GHWIS 651_ TFYML 656_ KWLLE 661_ HCYSV 666_ HHSLG 671_ RASGV 676_ VLTSL 681_ QWTLM 686_ TYVCD 691_ ILKPF 696_ EEATQ 701_ KVSVK 706_ TAGLN 711_ QVLPL 716_ IHHLL 721_ LSLQK 726_ LREDF 731_ QVRGI 736_ TQALN 741_ LVDSL 746_ SLKLE 751_ TDTLL 756_ SAMLK 761_ SKPCI 766_ LATLL 771_ DPCFK 776_ NSLED 781_ FFPQG 786_ ADLET 791_ YKQFL 796_ AEEVC 801_ NYMES 806_ SPEIC 811_ QIPTS 816_ EASCP 821_ SVTVG 826_ ADSFT 831_ SSLKE 836_ GTSSS 841_ GSVDS 846_ SAVDN 851_ VALGS 856_ KSFMF 861_ PSAVA 866_ VVDEY 871_ FKEKY 876_ SEFSG 881_ GDDPL 886_ IYWQR 891_ KISIW 896_ PALTQ 901_ VAIQY 906_ LSCPM 911_ CSWQS 916_ ECIFT 921_ KNSHF 926_ HPKQI 931_ MSLDF 936_ DNIEQ 941_ LMFLK 946_ MNLKN 951_ VNYDY 956_ STLVL 961_ SWDPE 966_ QNEVV 971_QSSEK
1: Transcriptional repressor which binds to the consensus sequence 5'-GCTCGC-3', transcription regulation may be tissue-specific (By similarity). Regulates the expression of target genes such as: IGF2, PGAP6/TMEM8, ENHO, and PIANP (By similarity). Acts as a transcriptional repressor of growth factor IGF2, thereby negatively regulating postnatal growth of muscles and internal organs, especially in females (By similarity). Negatively regulates myoblast differentiation and myoblast mitochondrial activity via its regulation of IGF2 transcription (By similarity). Negatively regulates the cell cycle of myoblasts, potentially via transcriptional regulation of the E2F family of transcription factors such as: E2F1 and E2F2 (By similarity). Positively regulates the cell cycle and survival of pancreatic beta cells (PubMed:24043816). Binds to the CDH2 gene and may directly repress CDH2 transcription (By similarity). Probably by controlling CDH2 expression, regulates pancreatic beta cell adhesion, and formation of cell-to-cell junctions between pancreatic beta cells and neural crest stem cells (By similarity). May also play a role in embryonic beta cell differentiation (By similarity). May play a role in insulin sensitivity and glucose clearance (By similarity)