Disabled homolog 2 (Adaptor molecule disabled-2) (Differentially expressed in ovarian carcinoma 2) (DOC-2) (Differentially-expressed protein 2)
1_MSNEV 6_ ETSAT 11_ NGQPD 16_ QQAAP 21_ KAPSK 26_ KEKKK 31_ GPEKT 36_ DEYLL 41_ ARFKG 46_ DGVKY 51_ KAKLI 56_ GIDDV 61_ PDARG 66_ DKMSQ 71_ DSMMK 76_ LKGMA 81_ AAGRS 86_ QGQHK 91_ QRIWV 96_ NISLS 101_ GIKII 106_ DEKTG 111_ VIEHE 116_ HPVNK 121_ ISFIA 126_ RDVTD 131_ NRAFG 136_ YVCGG 141_ EGQHQ 146_ FFAIK 151_ TGQQA 156_ EPLVV 161_ DLKDL 166_ FQVIY 171_ NVKKK 176_ EEEKK 181_ KIEEA 186_ SKAVE 191_ NGSEA 196_ LMILD 201_ DQTNK 206_ LKSGV 211_ DQMDL 216_ FGDMS 221_ TPPDL 226_ NSPTE 231_ SKDIL 236_ LVDLN 241_ SEIDT 246_ NQNSL 251_ RENPF 256_ LTNGI 261_ TSCSL 266_ PRPTP 271_ QASFL 276_ PENAF 281_ SANLN 286_ FFPTP 291_ NPDPF 296_ RDDPF 301_ TQPDQ 306_ STPSS 311_ FDSLK 316_ SPDQK 321_ KENSS 326_ SSSTP 331_ LSNGP 336_ LNGDV 341_ DYFGQ 346_ QFDQI 351_ SNRTG 356_ KQEAQ 361_ AGPWP 366_ FSSSQ 371_ TQPAV 376_ RTQNG 381_ VSERE 386_ QNGFS 391_ VKSSP 396_ NPFVG 401_ SPPKG 406_ LSIQN 411_ GVKQD 416_ LESSV 421_ QSSPH 426_ DSIAI 431_ IPPPQ 436_ STKPG 441_ RGRRT 446_ AKSSA 451_ NDLLA 456_ SDIFA 461_ PPVSE 466_ PSGQA 471_ SPTGQ 476_ PTALQ 481_ PNPLD 486_ LFKTS 491_ APAPV 496_ GPLVG 501_ LGGVT 506_ VTLPQ 511_ AGPWN 516_ TASLV 521_ FNQSP 526_ SMAPG 531_ AMMGG 536_ QPSGF 541_ SQPVI 546_ FGTSP 551_ AVSGW 556_ NQPSP 561_ FAAST 566_ PPPVP 571_ VVWGP 576_ SASVA 581_ PNAWS 586_ TTSPL 591_ GNPFQ 596_ SNIFP 601_ APAVS 606_ TQPPS 611_ MHSSL 616_ LVTPP 621_ QPPPR 626_ AGPPK 631_ DISSD 636_ AFTAL 641_ DPLGD 646_ KEIKD 651_ VKEMF 656_ KDFQL 661_ RQPPA 666_ VPARK 671_ GEQTS 676_ SGTLS 681_ AFASY 686_ FNSKV 691_ GIPQE 696_ NADHD 701_ DFDAN 706_ QLLNK 711_ INEPP 716_ KPAPR 721_ QVSLP 726_ VTKST 731_ DNAFE 736_ NPFFK 741_ DSFGS 746_ SQASV 751_ ASSQP 756_ VSSEM 761_YRDPF
1: Adapter protein that functions as a clathrin-associated sorting protein (CLASP) required for clathrin-mediated endocytosis of selected cargo proteins. Can bind and assemble clathrin, and binds simultaneously to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and cargos containing non-phosphorylated NPXY internalization motifs, such as the LDL receptor, to recruit them to clathrin-coated pits. Can function in clathrin-mediated endocytosis independently of the AP-2 complex. Involved in endocytosis of integrin beta-1; this function seems to redundant with the AP-2 complex and seems to require DAB2 binding to endocytosis accessory EH domain-containing proteins such as EPS15, EPS15L1 and ITSN1. Involved in endocytosis of cystic fibrosis transmembrane conductance regulator/CFTR. Involved in endocytosis of megalin/LRP2 lipoprotein receptor during embryonal development. Required for recycling of the TGF-beta receptor. Involved in CFTR trafficking to the late endosome. Involved in several receptor-mediated signaling pathways. Involved in TGF-beta receptor signaling and facilitates phosphorylation of the signal transducer SMAD2. Mediates TFG-beta-stimulated JNK activation. May inhibit the canoniocal Wnt/beta-catenin signaling pathway by stabilizing the beta-catenin destruction complex through a competing association with axin preventing its dephosphorylation through protein phosphatase 1 (PP1). Sequesters LRP6 towards clathrin-mediated endocytosis, leading to inhibition of Wnt/beta-catenin signaling. May activate non-canonical Wnt signaling. In cell surface growth factor/Ras signaling pathways proposed to inhibit ERK activation by interrupting the binding of GRB2 to SOS1 and to inhibit SRC by preventing its activating phosphorylation at 'Tyr-419'. Proposed to be involved in modulation of androgen receptor (AR) signaling mediated by SRC activation; seems to compete with AR for interaction with SRC. Plays a role in the CSF-1 signal transduction pathway. Plays a role in cellular differentiation. Involved in cell positioning and formation of visceral endoderm (VE) during embryogenesis and proposed to be required in the VE to respond to Nodal signaling coming from the epiblast. Required for the epithelial to mesenchymal transition, a process necessary for proper embryonic development. May be involved in myeloid cell differentiation and can induce macrophage adhesion and spreading. May act as a tumor suppressor