Very low-density lipoprotein receptor (VLDL receptor) (VLDL-R)
1_MGTSA 6_ LWALW 11_ LLLAL 16_ CWAPR 21_ ESGAT 26_ GTGRK 31_ AKCEP 36_ SQFQC 41_ TNGRC 46_ ITLLW 51_ KCDGD 56_ EDCVD 61_ GSDEK 66_ NCVKK 71_ TCAES 76_ DFVCN 81_ NGQCV 86_ PSRWK 91_ CDGDP 96_ DCEDG 101_ SDESP 106_ EQCHM 111_ RTCRI 116_ HEISC 121_ GAHST 126_ QCIPV 131_ SWRCD 136_ GENDC 141_ DSGED 146_ EENCG 151_ NITCS 156_ PDEFT 161_ CSSGR 166_ CISRN 171_ FVCNG 176_ QDDCS 181_ DGSDE 186_ LDCAP 191_ PTCGA 196_ HEFQC 201_ STSSC 206_ IPISW 211_ VCDDD 216_ ADCSD 221_ QSDES 226_ LEQCG 231_ RQPVI 236_ HTKCP 241_ ASEIQ 246_ CGSGE 251_ CIHKK 256_ WRCDG 261_ DPDCK 266_ DGSDE 271_ VNCPS 276_ RTCRP 281_ DQFEC 286_ EDGSC 291_ IHGSR 296_ QCNGI 301_ RDCVD 306_ GSDEV 311_ NCKNV 316_ NQCLG 321_ PGKFK 326_ CRSGE 331_ CIDIS 336_ KVCNQ 341_ EQDCR 346_ DWSDE 351_ PLKEC 356_ HINEC 361_ LVNNG 366_ GCSHI 371_ CKDLV 376_ IGYEC 381_ DCAAG 386_ FELID 391_ RKTCG 396_ DIDEC 401_ QNPGI 406_ CSQIC 411_ INLKG 416_ GYKCE 421_ CSRGY 426_ QMDLA 431_ TGVCK 436_ AVGKE 441_ PSLIF 446_ TNRRD 451_ IRKIG 456_ LERKE 461_ YIQLV 466_ EQLRN 471_ TVALD 476_ ADIAA 481_ QKLFW 486_ ADLSQ 491_ KAIFS 496_ ASIDD 501_ KVGRH 506_ VKMID 511_ NVYNP 516_ AAIAV 521_ DWVYK 526_ TIYWT 531_ DAASK 536_ TISVA 541_ TLDGT 546_ KRKFL 551_ FNSDL 556_ REPAS 561_ IAVDP 566_ LSGFV 571_ YWSDW 576_ GEPAK 581_ IEKAG 586_ MNGFD 591_ RRPLV 596_ TADIQ 601_ WPNGI 606_ TLDLI 611_ KSRLY 616_ WLDSK 621_ LHMLS 626_ SVDLN 631_ GQDRR 636_ IVLKS 641_ LEFLA 646_ HPLAL 651_ TIFED 656_ RVYWI 661_ DGENE 666_ AVYGA 671_ NKFTG 676_ SELAT 681_ LVNNL 686_ NDAQD 691_ IIVYH 696_ ELVQP 701_ SGKNW 706_ CEEDM 711_ ENGGC 716_ EYLCL 721_ PAPQI 726_ NDHSP 731_ KYTCS 736_ CPSGY 741_ NVEEN 746_ GRDCQ 751_ STATT 756_ VTYSE 761_ TKDTN 766_ TTEIS 771_ ATSGL 776_ VPGGI 781_ NVTTA 786_ VSEVS 791_ VPPKG 796_ TSAAW 801_ AILPL 806_ LLLVM 811_ AAVGG 816_ YLMWR 821_ NWQHK 826_ NMKSM 831_ NFDNP 836_ VYLKT 841_ TEEDL 846_ SIDIG 851_ RHSAS 856_ VGHTY 861_ PAISV 866_VSTDD
1: Multifunctional cell surface receptor that binds VLDL and transports it into cells by endocytosis and therefore plays an important role in energy metabolism. Also binds to a wide range of other molecules including Reelin/RELN or apolipoprotein E/APOE-containing ligands as well as clusterin/CLU (PubMed:24381170, PubMed:30873003). In the off-state of the pathway, forms homooligomers or heterooligomers with LRP8 (PubMed:30873003). Upon binding to ligands, homooligomers are rearranged to higher order receptor clusters that transmit the extracellular RELN signal to intracellular signaling processes by binding to DAB1 (PubMed:30873003). This interaction results in phosphorylation of DAB1 leading to the ultimate cell responses required for the correct positioning of newly generated neurons. Later, mediates a stop signal for migrating neurons, preventing them from entering the marginal zone (By similarity)
2: (Microbial infection) Acts as a receptor for Semliki Forest virus