Basement membrane-specific heparan sulfate proteoglycan core protein (HSPG) (Perlecan) (PLC) [Cleaved into: Endorepellin; LG3 peptide]
1_MGWRA 6_ AGALL 11_ LALLL 16_ HGRLL 21_ AVTHG 26_ LRAYD 31_ GLSLP 36_ EDIET 41_ VTASQ 46_ MRWTH 51_ SYLSD 56_ DEDML 61_ ADSIS 66_ GDDLG 71_ SGDLG 76_ SGDFQ 81_ MVYFR 86_ ALVNF 91_ TRSIE 96_ YSPQL 101_ EDAGS 106_ REFRE 111_ VSEAV 116_ VDTLE 121_ SEYLK 126_ IPGDQ 131_ VVSVV 136_ FIKEL 141_ DGWVF 146_ VELDV 151_ GSEGN 156_ ADGAQ 161_ IQEML 166_ LRVIS 171_ SGSVA 176_ SYVTS 181_ PQGFQ 186_ FRRLG 191_ TVPQF 196_ PRACT 201_ EAEFA 206_ CHSYN 211_ ECVAL 216_ EYRCD 221_ RRPDC 226_ RDMSD 231_ ELNCE 236_ EPVLG 241_ ISPTF 246_ SLLVE 251_ TTSLP 256_ PRPET 261_ TIMRQ 266_ PPVTH 271_ APQPL 276_ LPGSV 281_ RPLPC 286_ GPQEA 291_ ACRNG 296_ HCIPR 301_ DYLCD 306_ GQEDC 311_ EDGSD 316_ ELDCG 321_ PPPPC 326_ EPNEF 331_ PCGNG 336_ HCALK 341_ LWRCD 346_ GDFDC 351_ EDRTD 356_ EANCP 361_ TKRPE 366_ EVCGP 371_ TQFRC 376_ VSTNM 381_ CIPAS 386_ FHCDE 391_ ESDCP 396_ DRSDE 401_ FGCMP 406_ PQVVT 411_ PPRES 416_ IQASR 421_ GQTVT 426_ FTCVA 431_ IGVPT 436_ PIINW 441_ RLNWG 446_ HIPSH 451_ PRVTV 456_ TSEGG 461_ RGTLI 466_ IRDVK 471_ ESDQG 476_ AYTCE 481_ AMNAR 486_ GMVFG 491_ IPDGV 496_ LELVP 501_ QRGPC 506_ PDGHF 511_ YLEHS 516_ AACLP 521_ CFCFG 526_ ITSVC 531_ QSTRR 536_ FRDQI 541_ RLRFD 546_ QPDDF 551_ KGVNV 556_ TMPAQ 561_ PGTPP 566_ LSSTQ 571_ LQIDP 576_ SLHEF 581_ QLVDL 586_ SRRFL 591_ VHDSF 596_ WALPE 601_ QFLGN 606_ KVDSY 611_ GGSLR 616_ YNVRY 621_ ELARG 626_ MLEPV 631_ QRPDV 636_ VLMGA 641_ GYRLL 646_ SRGHT 651_ PTQPG 656_ ALNQR 661_ QVQFS 666_ EEHWV 671_ HESGR 676_ PVQRA 681_ ELLQV 686_ LQSLE 691_ AVLIQ 696_ TVYNT 701_ KMASV 706_ GLSDI 711_ AMDTT 716_ VTHAT 721_ SHGRA 726_ HSVEE 731_ CRCPI 736_ GYSGL 741_ SCESC 746_ DAHFT 751_ RVPGG 756_ PYLGT 761_ CSGCN 766_ CNGHA 771_ SSCDP 776_ VYGHC 781_ LNCQH 786_ NTEGP 791_ QCNKC 796_ KAGFF 801_ GDAMK 806_ ATATS 811_ CRPCP 816_ CPYID 821_ ASRRF 826_ SDTCF 831_ LDTDG 836_ QATCD 841_ ACAPG 846_ YTGRR 851_ CESCA 856_ PGYEG 861_ NPIQP 866_ GGKCR 871_ PVNQE 876_ IVRCD 881_ ERGSM 886_ GTSGE 891_ ACRCK 896_ NNVVG 901_ RLCNE 906_ CADGS 911_ FHLST 916_ RNPDG 921_ CLKCF 926_ CMGVS 931_ RHCTS 936_ SSWSR 941_ AQLHG 946_ ASEEP 951_ GHFSL 956_ TNAAS 961_ THTTN 966_ EGIFS 971_ PTPGE 976_ LGFSS 981_ FHRLL 986_ SGPYF 991_ WSLPS 996_ RFLGD 1001_ KVTSY 1006_ GGELR 1011_ FTVTQ 1016_ RSQPG 1021_ STPLH 1026_ GQPLV 1031_ VLQGN 1036_ NIILE 1041_ HHVAQ 1046_ EPSPG 1051_ QPSTF 1056_ IVPFR 1061_ EQAWQ 1066_ RPDGQ 1071_ PATRE 1076_ HLLMA 1081_ LAGID 1086_ TLLIR 1091_ ASYAQ 1096_ QPAES 1101_ RVSGI 1106_ SMDVA 1111_ VPEET 1116_ GQDPA 1121_ LEVEQ 1126_ CSCPP 1131_ GYRGP 1136_ SCQDC 1141_ DTGYT 1146_ RTPSG 1151_ LYLGT 1156_ CERCS 1161_ CHGHS 1166_ EACEP 1171_ ETGAC 1176_ QGCQH 1181_ HTEGP 1186_ RCEQC 1191_ QPGYY 1196_ GDAQR 1201_ GTPQD 1206_ CQLCP 1211_ CYGDP 1216_ AAGQA 1221_ AHTCF 1226_ LDTDG 1231_ HPTCD 1236_ ACSPG 1241_ HSGRH 1246_ CERCA 1251_ PGYYG 1256_ NPSQG 1261_ QPCQR 1266_ DSQVP 1271_ GPIGC 1276_ NCDPQ 1281_ GSVSS 1286_ QCDAA 1291_ GQCQC 1296_ KAQVE 1301_ GLTCS 1306_ HCRPH 1311_ HFHLS 1316_ ASNPD 1321_ GCLPC 1326_ FCMGI 1331_ TQQCA 1336_ SSAYT 1341_ RHLIS 1346_ THFAP 1351_ GDFQG 1356_ FALVN 1361_ PQRNS 1366_ RLTGE 1371_ FTVEP 1376_ VPEGA 1381_ QLSFG 1386_ NFAQL 1391_ GHESF 1396_ YWQLP 1401_ ETYQG 1406_ DKVAA 1411_ YGGKL 1416_ RYTLS 1421_ YTAGP 1426_ QGSPL 1431_ SDPDV 1436_ QITGN 1441_ NIMLV 1446_ ASQPA 1451_ LQGPE 1456_ RRSYE 1461_ IMFRE 1466_ EFWRR 1471_ PDGQP 1476_ ATREH 1481_ LLMAL 1486_ ADLDE 1491_ LLIRA 1496_ TFSSV 1501_ PLAAS 1506_ ISAVS 1511_ LEVAQ 1516_ PGPSN 1521_ RPRAL 1526_ EVEEC 1531_ RCPPG 1536_ YIGLS 1541_ CQDCA 1546_ PGYTR 1551_ TGSGL 1556_ YLGHC 1561_ ELCEC 1566_ NGHSD 1571_ LCHPE 1576_ TGACS 1581_ QCQHN 1586_ AAGEF 1591_ CELCA 1596_ PGYYG 1601_ DATAG 1606_ TPEDC 1611_ QPCAC 1616_ PLTNP 1621_ ENMFS 1626_ RTCES 1631_ LGAGG 1636_ YRCTA 1641_ CEPGY 1646_ TGQYC 1651_ EQCGP 1656_ GYVGN 1661_ PSVQG 1666_ GQCLP 1671_ ETNQA 1676_ PLVVE 1681_ VHPAR 1686_ SIVPQ 1691_ GGSHS 1696_ LRCQV 1701_ SGSPP 1706_ HYFYW 1711_ SREDG 1716_ RPVPS 1721_ GTQQR 1726_ HQGSE 1731_ LHFPS 1736_ VQPSD 1741_ AGVYI 1746_ CTCRN 1751_ LHQSN 1756_ TSRAE 1761_ LLVTE 1766_ APSKP 1771_ ITVTV 1776_ EEQRS 1781_ QSVRP 1786_ GADVT 1791_ FICTA 1796_ KSKSP 1801_ AYTLV 1806_ WTRLH 1811_ NGKLP 1816_ TRAMD 1821_ FNGIL 1826_ TIRNV 1831_ QLSDA 1836_ GTYVC 1841_ TGSNM 1846_ FAMDQ 1851_ GTATL 1856_ HVQAS 1861_ GTLSA 1866_ PVVSI 1871_ HPPQL 1876_ TVQPG 1881_ QLAEF 1886_ RCSAT 1891_ GSPTP 1896_ TLEWT 1901_ GGPGG 1906_ QLPAK 1911_ AQIHG 1916_ GILRL 1921_ PAVEP 1926_ TDQAQ 1931_ YLCRA 1936_ HSSAG 1941_ QQVAR 1946_ AVLHV 1951_ HGGGG 1956_ PRVQV 1961_ SPERT 1966_ QVHAG 1971_ RTVRL 1976_ YCRAA 1981_ GVPSA 1986_ TITWR 1991_ KEGGS 1996_ LPPQA 2001_ RSERT 2006_ DIATL 2011_ LIPAI 2016_ TTADA 2021_ GFYLC 2026_ VATSP 2031_ AGTAQ 2036_ ARIQV 2041_ VVLSA 2046_ SDASP 2051_ PPVKI 2056_ ESSSP 2061_ SVTEG 2066_ QTLDL 2071_ NCVVA 2076_ GSAHA 2081_ QVTWY 2086_ RRGGS 2091_ LPPHT 2096_ QVHGS 2101_ RLRLP 2106_ QVSPA 2111_ DSGEY 2116_ VCRVE 2121_ NGSGP 2126_ KEASI 2131_ TVSVL 2136_ HGTHS 2141_ GPSYT 2146_ PVPGS 2151_ TRPIR 2156_ IEPSS 2161_ SHVAE 2166_ GQTLD 2171_ LNCVV 2176_ PGQAH 2181_ AQVTW 2186_ HKRGG 2191_ SLPAR 2196_ HQTHG 2201_ SLLRL 2206_ HQVTP 2211_ ADSGE 2216_ YVCHV 2221_ VGTSG 2226_ PLEAS 2231_ VLVTI 2236_ EASVI 2241_ PGPIP 2246_ PVRIE 2251_ SSSST 2256_ VAEGQ 2261_ TLDLS 2266_ CVVAG 2271_ QAHAQ 2276_ VTWYK 2281_ RGGSL 2286_ PARHQ 2291_ VRGSR 2296_ LYIFQ 2301_ ASPAD 2306_ AGQYV 2311_ CRASN 2316_ GMEAS 2321_ ITVTV 2326_ TGTQG 2331_ ANLAY 2336_ PAGST 2341_ QPIRI 2346_ EPSSS 2351_ QVAEG 2356_ QTLDL 2361_ NCVVP 2366_ GQSHA 2371_ QVTWH 2376_ KRGGS 2381_ LPVRH 2386_ QTHGS 2391_ LLRLY 2396_ QASPA 2401_ DSGEY 2406_ VCRVL 2411_ GSSVP 2416_ LEASV 2421_ LVTIE 2426_ PAGSV 2431_ PALGV 2436_ TPTVR 2441_ IESSS 2446_ SQVAE 2451_ GQTLD 2456_ LNCLV 2461_ AGQAH 2466_ AQVTW 2471_ HKRGG 2476_ SLPAR 2481_ HQVHG 2486_ SRLRL 2491_ LQVTP 2496_ ADSGE 2501_ YVCRV 2506_ VGSSG 2511_ TQEAS 2516_ VLVTI 2521_ QQRLS 2526_ GSHSQ 2531_ GVAYP 2536_ VRIES 2541_ SSASL 2546_ ANGHT 2551_ LDLNC 2556_ LVASQ 2561_ APHTI 2566_ TWYKR 2571_ GGSLP 2576_ SRHQI 2581_ VGSRL 2586_ RIPQV 2591_ TPADS 2596_ GEYVC 2601_ HVSNG 2606_ AGSRE 2611_ TSLIV 2616_ TIQGS 2621_ GSSHV 2626_ PSVSP 2631_ PIRIE 2636_ SSSPT 2641_ VVEGQ 2646_ TLDLN 2651_ CVVAR 2656_ QPQAI 2661_ ITWYK 2666_ RGGSL 2671_ PSRHQ 2676_ THGSH 2681_ LRLHQ 2686_ MSVAD 2691_ SGEYV 2696_ CRANN 2701_ NIDAL 2706_ EASIV 2711_ ISVSP 2716_ SAGSP 2721_ SAPGS 2726_ SMPIR 2731_ IESSS 2736_ SHVAE 2741_ GETLD 2746_ LNCVV 2751_ PGQAH 2756_ AQVTW 2761_ HKRGG 2766_ SLPSH 2771_ HQTRG 2776_ SRLRL 2781_ HHVSP 2786_ ADSGE 2791_ YVCRV 2796_ MGSSG 2801_ PLEAS 2806_ VLVTI 2811_ EASGS 2816_ SAVHV 2821_ PAPGG 2826_ APPIR 2831_ IEPSS 2836_ SRVAE 2841_ GQTLD 2846_ LKCVV 2851_ PGQAH 2856_ AQVTW 2861_ HKRGG 2866_ NLPAR 2871_ HQVHG 2876_ PLLRL 2881_ NQVSP 2886_ ADSGE 2891_ YSCQV 2896_ TGSSG 2901_ TLEAS 2906_ VLVTI 2911_ EPSSP 2916_ GPIPA 2921_ PGLAQ 2926_ PIYIE 2931_ ASSSH 2936_ VTEGQ 2941_ TLDLN 2946_ CVVPG 2951_ QAHAQ 2956_ VTWYK 2961_ RGGSL 2966_ PARHQ 2971_ THGSQ 2976_ LRLHL 2981_ VSPAD 2986_ SGEYV 2991_ CRAAS 2996_ GPGPE 3001_ QEASF 3006_ TVTVP 3011_ PSEGS 3016_ SYRLR 3021_ SPVIS 3026_ IDPPS 3031_ STVQQ 3036_ GQDAS 3041_ FKCLI 3046_ HDGAA 3051_ PISLE 3056_ WKTRN 3061_ QELED 3066_ NVHIS 3071_ PNGSI 3076_ ITIVG 3081_ TRPSN 3086_ HGTYR 3091_ CVASN 3096_ AYGVA 3101_ QSVVN 3106_ LSVHG 3111_ PPTVS 3116_ VLPEG 3121_ PVWVK 3126_ VGKAV 3131_ TLECV 3136_ SAGEP 3141_ RSSAR 3146_ WTRIS 3151_ STPAK 3156_ LEQRT 3161_ YGLMD 3166_ SHAVL 3171_ QISSA 3176_ KPSDA 3181_ GTYVC 3186_ LAQNA 3191_ LGTAQ 3196_ KQVEV 3201_ IVDTG 3206_ AMAPG 3211_ APQVQ 3216_ AEEAE 3221_ LTVEA 3226_ GHTAT 3231_ LRCSA 3236_ TGSPA 3241_ PTIHW 3246_ SKLRS 3251_ PLPWQ 3256_ HRLEG 3261_ DTLII 3266_ PRVAQ 3271_ QDSGQ 3276_ YICNA 3281_ TSPAG 3286_ HAEAT 3291_ IILHV 3296_ ESPPY 3301_ ATTVP 3306_ EHASV 3311_ QAGET 3316_ VQLQC 3321_ LAHGT 3326_ PPLTF 3331_ QWSRV 3336_ GSSLP 3341_ GRATA 3346_ RNELL 3351_ HFERA 3356_ APEDS 3361_ GRYRC 3366_ RVTNK 3371_ VGSAE 3376_ AFAQL 3381_ LVQGP 3386_ PGSLP 3391_ ATSIP 3396_ AGSTP 3401_ TVQVT 3406_ PQLET 3411_ KSIGA 3416_ SVEFH 3421_ CAVPS 3426_ DRGTQ 3431_ LRWFK 3436_ EGGQL 3441_ PPGHS 3446_ VQDGV 3451_ LRIQN 3456_ LDQSC 3461_ QGTYI 3466_ CQAHG 3471_ PWGKA 3476_ QASAQ 3481_ LVIQA 3486_ LPSVL 3491_ INIRT 3496_ SVQTV 3501_ VVGHA 3506_ VEFEC 3511_ LALGD 3516_ PKPQV 3521_ TWSKV 3526_ GGHLR 3531_ PGIVQ 3536_ SGGVV 3541_ RIAHV 3546_ ELADA 3551_ GQYRC 3556_ TATNA 3561_ AGTTQ 3566_ SHVLL 3571_ LVQAL 3576_ PQISM 3581_ PQEVR 3586_ VPAGS 3591_ AAVFP 3596_ CIASG 3601_ YPTPD 3606_ ISWSK 3611_ LDGSL 3616_ PPDSR 3621_ LENNM 3626_ LMLPS 3631_ VRPQD 3636_ AGTYV 3641_ CTATN 3646_ RQGKV 3651_ KAFAH 3656_ LQVPE 3661_ RVVPY 3666_ FTQTP 3671_ YSFLP 3676_ LPTIK 3681_ DAYRK 3686_ FEIKI 3691_ TFRPD 3696_ SADGM 3701_ LLYNG 3706_ QKRVP 3711_ GSPTN 3716_ LANRQ 3721_ PDFIS 3726_ FGLVG 3731_ GRPEF 3736_ RFDAG 3741_ SGMAT 3746_ IRHPT 3751_ PLALG 3756_ HFHTV 3761_ TLLRS 3766_ LTQGS 3771_ LIVGD 3776_ LAPVN 3781_ GTSQG 3786_ KFQGL 3791_ DLNEE 3796_ LYLGG 3801_ YPDYG 3806_ AIPKA 3811_ GLSSG 3816_ FIGCV 3821_ RELRI 3826_ QGEEI 3831_ VFHDL 3836_ NLTAH 3841_ GISHC 3846_ PTCRD 3851_ RPCQN 3856_ GGQCH 3861_ DSESS 3866_ SYVCV 3871_ CPAGF 3876_ TGSRC 3881_ EHSQA 3886_ LHCHP 3891_ EACGP 3896_ DATCV 3901_ NRPDG 3906_ RGYTC 3911_ RCHLG 3916_ RSGLR 3921_ CEEGV 3926_ TVTTP 3931_ SLSGA 3936_ GSYLA 3941_ LPALT 3946_ NTHHE 3951_ LRLDV 3956_ EFKPL 3961_ APDGV 3966_ LLFSG 3971_ GKSGP 3976_ VEDFV 3981_ SLAMV 3986_ GGHLE 3991_ FRYEL 3996_ GSGLA 4001_ VLRSA 4006_ EPLAL 4011_ GRWHR 4016_ VSAER 4021_ LNKDG 4026_ SLRVN 4031_ GGRPV 4036_ LRSSP 4041_ GKSQG 4046_ LNLHT 4051_ LLYLG 4056_ GVEPS 4061_ VPLSP 4066_ ATNMS 4071_ AHFRG 4076_ CVGEV 4081_ SVNGK 4086_ RLDLT 4091_ YSFLG 4096_ SQGIG 4101_ QCYDS 4106_ SPCER 4111_ QPCQH 4116_ GATCM 4121_ PAGEY 4126_ EFQCL 4131_ CRDGF 4136_ KGDLC 4141_ EHEEN 4146_ PCQLR 4151_ EPCLH 4156_ GGTCQ 4161_ GTRCL 4166_ CLPGF 4171_ SGPRC 4176_ QQGSG 4181_ HGIAE 4186_ SDWHL 4191_ EGSGG 4196_ NDAPG 4201_ QYGAY 4206_ FHDDG 4211_ FLAFP 4216_ GHVFS 4221_ RSLPE 4226_ VPETI 4231_ ELEVR 4236_ TSTAS 4241_ GLLLW 4246_ QGVEV 4251_ GEAGQ 4256_ GKDFI 4261_ SLGLQ 4266_ DGHLV 4271_ FRYQL 4276_ GSGEA 4281_ RLVSE 4286_ DPIND 4291_ GEWHR 4296_ VTALR 4301_ EGRRG 4306_ SIQVD 4311_ GEELV 4316_ SGRSP 4321_ GPNVA 4326_ VNAKG 4331_ SVYIG 4336_ GAPDV 4341_ ATLTG 4346_ GRFSS 4351_ GITGC 4356_ VKNLV 4361_ LHSAR 4366_ PGAPP 4371_ PQPLD 4376_ LQHRA 4381_ QAGAN 4386_TRPCP
1: Integral component of basement membranes. Component of the glomerular basement membrane (GBM), responsible for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and charge-selective. It serves as an attachment substrate for cells. Plays essential roles in vascularization. Critical for normal heart development and for regulating the vascular response to injury. Also required for avascular cartilage development
2: Anti-angiogenic and anti-tumor peptide that inhibits endothelial cell migration, collagen-induced endothelial tube morphogenesis and blood vessel growth in the chorioallantoic membrane. Blocks endothelial cell adhesion to fibronectin and type I collagen. Anti-tumor agent in neovascularization. Interaction with its ligand, integrin alpha2/beta1, is required for the anti-angiogenic properties. Evokes a reduction in phosphorylation of receptor tyrosine kinases via alpha2/beta1 integrin-mediated activation of the tyrosine phosphatase, PTPN6
3: Has anti-angiogenic properties that require binding of calcium ions for full activity