Low-density lipoprotein receptor-related protein 2 (LRP-2) (Glycoprotein 330) (gp330) (Megalin)
1_MDRGP 6_ AAVAC 11_ TLLLA 16_ LVACL 21_ APASG 26_ QECDS 31_ AHFRC 36_ GSGHC 41_ IPADW 46_ RCDGT 51_ KDCSD 56_ DADEI 61_ GCAVV 66_ TCQQG 71_ YFKCQ 76_ SEGQC 81_ IPNSW 86_ VCDQD 91_ QDCDD 96_ GSDER 101_ QDCSQ 106_ STCSS 111_ HQITC 116_ SNGQC 121_ IPSEY 126_ RCDHV 131_ RDCPD 136_ GADEN 141_ DCQYP 146_ TCEQL 151_ TCDNG 156_ ACYNT 161_ SQKCD 166_ WKVDC 171_ RDSSD 176_ EINCT 181_ EICLH 186_ NEFSC 191_ GNGEC 196_ IPRAY 201_ VCDHD 206_ NDCQD 211_ GSDEH 216_ ACNYP 221_ TCGGY 226_ QFTCP 231_ SGRCI 236_ YQNWV 241_ CDGED 246_ DCKDN 251_ GDEDG 256_ CESGP 261_ HDVHK 266_ CSPRE 271_ WSCPE 276_ SGRCI 281_ SIYKV 286_ CDGIL 291_ DCPGR 296_ EDENN 301_ TSTGK 306_ YCSMT 311_ LCSAL 316_ NCQYQ 321_ CHETP 326_ YGGAC 331_ FCPPG 336_ YIINH 341_ NDSRT 346_ CVEFD 351_ DCQIW 356_ GICDQ 361_ KCESR 366_ PGRHL 371_ CHCEE 376_ GYILE 381_ RGQYC 386_ KANDS 391_ FGEAS 396_ IIFSN 401_ GRDLL 406_ IGDIH 411_ GRSFR 416_ ILVES 421_ QNRGV 426_ AVGVA 431_ FHYHL 436_ QRVFW 441_ TDTVQ 446_ NKVFS 451_ VDING 456_ LNIQE 461_ VLNVS 466_ VETPE 471_ NLAVD 476_ WVNNK 481_ IYLVE 486_ TKVNR 491_ IDMVN 496_ LDGSY 501_ RVTLI 506_ TENLG 511_ HPRGI 516_ AVDPT 521_ VGYLF 526_ FSDWE 531_ SLSGE 536_ PKLER 541_ AFMDG 546_ SNRKD 551_ LVKTK 556_ LGWPA 561_ GVTLD 566_ MISKR 571_ VYWVD 576_ SRFDY 581_ IETVT 586_ YDGIQ 591_ RKTVV 596_ HGGSL 601_ IPHPF 606_ GVSLF 611_ EGQVF 616_ FTDWT 621_ KMAVL 626_ KANKF 631_ TETNP 636_ QVYYQ 641_ ASLRP 646_ YGVTV 651_ YHSLR 656_ QPYAT 661_ NPCKD 666_ NNGGC 671_ EQVCV 676_ LSHRT 681_ DNDGL 686_ GFRCK 691_ CTFGF 696_ QLDTD 701_ ERHCI 706_ AVQNF 711_ LIFSS 716_ QVAIR 721_ GIPFT 726_ LSTQE 731_ DVMVP 736_ VSGNP 741_ SFFVG 746_ IDFDA 751_ QDSTI 756_ FFSDM 761_ SKHMI 766_ FKQKI 771_ DGTGR 776_ EILAA 781_ NRVEN 786_ VESLA 791_ FDWIS 796_ KNLYW 801_ TDSHY 806_ KSISV 811_ MRLAD 816_ KTRRT 821_ VVQYL 826_ NNPRS 831_ VVVHP 836_ FAGYL 841_ FFTDW 846_ FRPAK 851_ IMRAW 856_ SDGSH 861_ LLPVI 866_ NTTLG 871_ WPNGL 876_ AIDWA 881_ ASRLY 886_ WVDAY 891_ FDKIE 896_ HSTFD 901_ GLDRR 906_ RLGHI 911_ EQMTH 916_ PFGLA 921_ IFGEH 926_ LFFTD 931_ WRLGA 936_ IIRVR 941_ KADGG 946_ EMTVI 951_ RSGIA 956_ YILHL 961_ KSYDV 966_ NIQTG 971_ SNACN 976_ QPTHP 981_ NGDCS 986_ HFCFP 991_ VPNFQ 996_ RVCGC 1001_ PYGMR 1006_ LASNH 1011_ LTCEG 1016_ DPTNE 1021_ PPTEQ 1026_ CGLFS 1031_ FPCKN 1036_ GRCVP 1041_ NYYLC 1046_ DGVDD 1051_ CHDNS 1056_ DEQLC 1061_ GTLNN 1066_ TCSSS 1071_ AFTCG 1076_ HGECI 1081_ PAHWR 1086_ CDKRN 1091_ DCVDG 1096_ SDEHN 1101_ CPTHA 1106_ PASCL 1111_ DTQYT 1116_ CDNHQ 1121_ CISKN 1126_ WVCDT 1131_ DNDCG 1136_ DGSDE 1141_ KNCNS 1146_ TETCQ 1151_ PSQFN 1156_ CPNHR 1161_ CIDLS 1166_ FVCDG 1171_ DKDCV 1176_ DGSDE 1181_ VGCVL 1186_ NCTAS 1191_ QFKCA 1196_ SGDKC 1201_ IGVTN 1206_ RCDGV 1211_ FDCSD 1216_ NSDEA 1221_ GCPTR 1226_ PPGMC 1231_ HSDEF 1236_ QCQED 1241_ GICIP 1246_ NFWEC 1251_ DGHPD 1256_ CLYGS 1261_ DEHNA 1266_ CVPKT 1271_ CPSSY 1276_ FHCDN 1281_ GNCIH 1286_ RAWLC 1291_ DRDND 1296_ CGDMS 1301_ DEKDC 1306_ PTQPF 1311_ RCPSW 1316_ QWQCL 1321_ GHNIC 1326_ VNLSV 1331_ VCDGI 1336_ FDCPN 1341_ GTDES 1346_ PLCNG 1351_ NSCSD 1356_ FNGGC 1361_ THECV 1366_ QEPFG 1371_ AKCLC 1376_ PLGFL 1381_ LANDS 1386_ KTCED 1391_ IDECD 1396_ ILGSC 1401_ SQHCY 1406_ NMRGS 1411_ FRCSC 1416_ DTGYM 1421_ LESDG 1426_ RTCKV 1431_ TASES 1436_ LLLLV 1441_ ASQNK 1446_ IIADS 1451_ VTSQV 1456_ HNIYS 1461_ LVENG 1466_ SYIVA 1471_ VDFDS 1476_ ISGRI 1481_ FWSDA 1486_ TQGKT 1491_ WSAFQ 1496_ NGTDR 1501_ RVVFD 1506_ SSIIL 1511_ TETIA 1516_ IDWVG 1521_ RNLYW 1526_ TDYAL 1531_ ETIEV 1536_ SKIDG 1541_ SHRTV 1546_ LISKN 1551_ LTNPR 1556_ GLALD 1561_ PRMNE 1566_ HLLFW 1571_ SDWGH 1576_ HPRIE 1581_ RASMD 1586_ GSMRT 1591_ VIVQD 1596_ KIFWP 1601_ CGLTI 1606_ DYPNR 1611_ LLYFM 1616_ DSYLD 1621_ YMDFC 1626_ DYNGH 1631_ HRRQV 1636_ IASDL 1641_ IIRHP 1646_ YALTL 1651_ FEDSV 1656_ YWTDR 1661_ ATRRV 1666_ MRANK 1671_ WHGGN 1676_ QSVVM 1681_ YNIQW 1686_ PLGIV 1691_ AVHPS 1696_ KQPNS 1701_ VNPCA 1706_ FSRCS 1711_ HLCLL 1716_ SSQGP 1721_ HFYSC 1726_ VCPSG 1731_ WSLSP 1736_ DLLNC 1741_ LRDDQ 1746_ PFLIT 1751_ VRQHI 1756_ IFGIS 1761_ LNPEV 1766_ KSNDA 1771_ MVPIA 1776_ GIQNG 1781_ LDVEF 1786_ DDAEQ 1791_ YIYWV 1796_ ENPGE 1801_ IHRVK 1806_ TDGTN 1811_ RTVFA 1816_ SISMV 1821_ GPSMN 1826_ LALDW 1831_ ISRNL 1836_ YSTNP 1841_ RTQSI 1846_ EVLTL 1851_ HGDIR 1856_ YRKTL 1861_ IANDG 1866_ TALGV 1871_ GFPIG 1876_ ITVDP 1881_ ARGKL 1886_ YWSDQ 1891_ GTDSG 1896_ VPAKI 1901_ ASANM 1906_ DGTSV 1911_ KTLFT 1916_ GNLEH 1921_ LECVT 1926_ LDIEE 1931_ QKLYW 1936_ AVTGR 1941_ GVIER 1946_ GNVDG 1951_ TDRMI 1956_ LVHQL 1961_ SHPWG 1966_ IAVHD 1971_ SFLYY 1976_ TDEQY 1981_ EVIER 1986_ VDKAT 1991_ GANKI 1996_ VLRDN 2001_ VPNLR 2006_ GLQVY 2011_ HRRNA 2016_ AESSN 2021_ GCSNN 2026_ MNACQ 2031_ QICLP 2036_ VPGGL 2041_ FSCAC 2046_ ATGFK 2051_ LNPDN 2056_ RSCSP 2061_ YNSFI 2066_ VVSML 2071_ SAIRG 2076_ FSLEL 2081_ SDHSE 2086_ TMVPV 2091_ AGQGR 2096_ NALHV 2101_ DVDVS 2106_ SGFIY 2111_ WCDFS 2116_ SSVAS 2121_ DNAIR 2126_ RIKPD 2131_ GSSLM 2136_ NIVTH 2141_ GIGEN 2146_ GVRGI 2151_ AVDWV 2156_ AGNLY 2161_ FTNAF 2166_ VSETL 2171_ IEVLR 2176_ INTTY 2181_ RRVLL 2186_ KVTVD 2191_ MPRHI 2196_ VVDPK 2201_ NRYLF 2206_ WADYG 2211_ QRPKI 2216_ ERSFL 2221_ DCTNR 2226_ TVLVS 2231_ EGIVT 2236_ PRGLA 2241_ VDRSD 2246_ GYVYW 2251_ VDDSL 2256_ DIIAR 2261_ IRING 2266_ ENSEV 2271_ IRYGS 2276_ RYPTP 2281_ YGITV 2286_ FENSI 2291_ IWVDR 2296_ NLKKI 2301_ FQASK 2306_ EPENT 2311_ EPPTV 2316_ IRDNI 2321_ NWLRD 2326_ VTIFD 2331_ KQVQP 2336_ RSPAE 2341_ VNNNP 2346_ CLENN 2351_ GGCSH 2356_ LCFAL 2361_ PGLHT 2366_ PKCDC 2371_ AFGTL 2376_ QSDGK 2381_ NCAIS 2386_ TENFL 2391_ IFALS 2396_ NSLRS 2401_ LHLDP 2406_ ENHSP 2411_ PFQTI 2416_ NVERT 2421_ VMSLD 2426_ YDSVS 2431_ DRIYF 2436_ TQNLA 2441_ SGVGQ 2446_ ISYAT 2451_ LSSGI 2456_ HTPTV 2461_ IASGI 2466_ GTADG 2471_ IAFDW 2476_ ITRRI 2481_ YYSDY 2486_ LNQMI 2491_ NSMAE 2496_ DGSNR 2501_ TVIAR 2506_ VPKPR 2511_ AIVLD 2516_ PCQGY 2521_ LYWAD 2526_ WDTHA 2531_ KIERA 2536_ TLGGN 2541_ FRVPI 2546_ VNSSL 2551_ VMPSG 2556_ LTLDY 2561_ EEDLL 2566_ YWVDA 2571_ SLQRI 2576_ ERSTL 2581_ TGVDR 2586_ EVIVN 2591_ AAVHA 2596_ FGLTL 2601_ YGQYI 2606_ YWTDL 2611_ YTQRI 2616_ YRANK 2621_ YDGSG 2626_ QIAMT 2631_ TNLLS 2636_ QPRGI 2641_ NTVVK 2646_ NQKQQ 2651_ CNNPC 2656_ EQFNG 2661_ GCSHI 2666_ CAPGP 2671_ NGAEC 2676_ QCPHE 2681_ GNWYL 2686_ ANNRK 2691_ HCIVD 2696_ NGERC 2701_ GASSF 2706_ TCSNG 2711_ RCISE 2716_ EWKCD 2721_ NDNDC 2726_ GDGSD 2731_ EMESV 2736_ CALHT 2741_ CSPTA 2746_ FTCAN 2751_ GRCVQ 2756_ YSYRC 2761_ DYYND 2766_ CGDGS 2771_ DEAGC 2776_ LFRDC 2781_ NATTE 2786_ FMCNN 2791_ RRCIP 2796_ REFIC 2801_ NGVDN 2806_ CHDNN 2811_ TSDEK 2816_ NCPDR 2821_ TCQSG 2826_ YTKCH 2831_ NSNIC 2836_ IPRVY 2841_ LCDGD 2846_ NDCGD 2851_ NSDEN 2856_ PTYCT 2861_ THTCS 2866_ SSEFQ 2871_ CASGR 2876_ CIPQH 2881_ WYCDQ 2886_ ETDCF 2891_ DASDE 2896_ PASCG 2901_ HSERT 2906_ CLADE 2911_ FKCDG 2916_ GRCIP 2921_ SEWIC 2926_ DGDND 2931_ CGDMS 2936_ DEDKR 2941_ HQCQN 2946_ QNCSD 2951_ SEFLC 2956_ VNDRP 2961_ PDRRC 2966_ IPQSW 2971_ VCDGD 2976_ VDCTD 2981_ GYDEN 2986_ QNCTR 2991_ RTCSE 2996_ NEFTC 3001_ GYGLC 3006_ IPKIF 3011_ RCDRH 3016_ NDCGD 3021_ YSDER 3026_ GCLYQ 3031_ TCQQN 3036_ QFTCQ 3041_ NGRCI 3046_ SKTFV 3051_ CDEDN 3056_ DCGDG 3061_ SDELM 3066_ HLCHT 3071_ PEPTC 3076_ PPHEF 3081_ KCDNG 3086_ RCIEM 3091_ MKLCN 3096_ HLDDC 3101_ LDNSD 3106_ EKGCG 3111_ INECH 3116_ DPSIS 3121_ GCDHN 3126_ CTDTL 3131_ TSFYC 3136_ SCRPG 3141_ YKLMS 3146_ DKRTC 3151_ VDIDE 3156_ CTEMP 3161_ FVCSQ 3166_ KCENV 3171_ IGSYI 3176_ CKCAP 3181_ GYLRE 3186_ PDGKT 3191_ CRQNS 3196_ NIEPY 3201_ LIFSN 3206_ RYYLR 3211_ NLTID 3216_ GYFYS 3221_ LILEG 3226_ LDNVV 3231_ ALDFD 3236_ RVEKR 3241_ LYWID 3246_ TQRQV 3251_ IERMF 3256_ LNKTN 3261_ KETII 3266_ NHRLP 3271_ AAESL 3276_ AVDWV 3281_ SRKLY 3286_ WLDAR 3291_ LDGLF 3296_ VSDLN 3301_ GGHRR 3306_ MLAQH 3311_ CVDAN 3316_ NTFCF 3321_ DNPRG 3326_ LALHP 3331_ QYGYL 3336_ YWADW 3341_ GHRAY 3346_ IGRVG 3351_ MDGTN 3356_ KSVII 3361_ STKLE 3366_ WPNGI 3371_ TIDYT 3376_ NDLLY 3381_ WADAH 3386_ LGYIE 3391_ YSDLE 3396_ GHHRH 3401_ TVYDG 3406_ ALPHP 3411_ FAITI 3416_ FEDTI 3421_ YWTDW 3426_ NTRTV 3431_ EKGNK 3436_ YDGSN 3441_ RQTLV 3446_ NTTHR 3451_ PFDIH 3456_ VYHPY 3461_ RQPIV 3466_ SNPCG 3471_ TNNGG 3476_ CSHLC 3481_ LIKPG 3486_ GKGFT 3491_ CECPD 3496_ DFRTL 3501_ QLSGS 3506_ TYCMP 3511_ MCSST 3516_ QFLCA 3521_ NNEKC 3526_ IPIWW 3531_ KCDGQ 3536_ KDCSD 3541_ GSDEL 3546_ ALCPQ 3551_ RFCRL 3556_ GQFQC 3561_ SDGNC 3566_ TSPQT 3571_ LCNAH 3576_ QNCPD 3581_ GSDED 3586_ RLLCE 3591_ NHHCD 3596_ SNEWQ 3601_ CANKR 3606_ CIPES 3611_ WQCDT 3616_ FNDCE 3621_ DNSDE 3626_ DSSHC 3631_ ASRTC 3636_ RPGQF 3641_ RCANG 3646_ RCIPQ 3651_ AWKCD 3656_ VDNDC 3661_ GDHSD 3666_ EPIEE 3671_ CMSSA 3676_ HLCDN 3681_ FTEFS 3686_ CKTNY 3691_ RCIPK 3696_ WAVCN 3701_ GVDDC 3706_ RDNSD 3711_ EQGCE 3716_ ERTCH 3721_ PVGDF 3726_ RCKNH 3731_ HCIPL 3736_ RWQCD 3741_ GQNDC 3746_ GDNSD 3751_ EENCA 3756_ PRECT 3761_ ESEFR 3766_ CVNQQ 3771_ CIPSR 3776_ WICDH 3781_ YNDCG 3786_ DNSDE 3791_ RDCEM 3796_ RTCHP 3801_ EYFQC 3806_ TSGHC 3811_ VHSEL 3816_ KCDGS 3821_ ADCLD 3826_ ASDEA 3831_ DCPTR 3836_ FPDGA 3841_ YCQAT 3846_ MFECK 3851_ NHVCI 3856_ PPYWK 3861_ CDGDD 3866_ DCGDG 3871_ SDEEL 3876_ HLCLD 3881_ VPCNS 3886_ PNRFR 3891_ CDNNR 3896_ CIYSH 3901_ EVCNG 3906_ VDDCG 3911_ DGTDE 3916_ TEEHC 3921_ RKPTP 3926_ KPCTE 3931_ YEYKC 3936_ GNGHC 3941_ IPHDN 3946_ VCDDA 3951_ DDCGD 3956_ WSDEL 3961_ GCNKG 3966_ KERTC 3971_ AENIC 3976_ EQNCT 3981_ QLNEG 3986_ GFICS 3991_ CTAGF 3996_ ETNVF 4001_ DRTSC 4006_ LDINE 4011_ CEQFG 4016_ TCPQH 4021_ CRNTK 4026_ GSYEC 4031_ VCADG 4036_ FTSMS 4041_ DRPGK 4046_ RCAAE 4051_ GSSPL 4056_ LLLPD 4061_ NVRIR 4066_ KYNLS 4071_ SERFS 4076_ EYLQD 4081_ EEYIQ 4086_ AVDYD 4091_ WDPKD 4096_ IGLSV 4101_ VYYTV 4106_ RGEGS 4111_ RFGAI 4116_ KRAYI 4121_ PNFES 4126_ GRNNL 4131_ VQEVD 4136_ LKLKY 4141_ VMQPD 4146_ GIAVD 4151_ WVGRH 4156_ IYWSD 4161_ VKNKR 4166_ IEVAK 4171_ LDGRY 4176_ RKWLI 4181_ STDLD 4186_ QPAAI 4191_ AVNPK 4196_ LGLMF 4201_ WTDWG 4206_ KEPKI 4211_ ESAWM 4216_ NGEDR 4221_ NILVF 4226_ EDLGW 4231_ PTGLS 4236_ IDYLN 4241_ NDRIY 4246_ WSDFK 4251_ EDVIE 4256_ TIKYD 4261_ GTDRR 4266_ VIAKE 4271_ AMNPY 4276_ SLDIF 4281_ EDQLY 4286_ WISKE 4291_ KGEVW 4296_ KQNKF 4301_ GQGKK 4306_ EKTLV 4311_ VNPWL 4316_ TQVRI 4321_ FHQLR 4326_ YNKSV 4331_ PNLCK 4336_ QICSH 4341_ LCLLR 4346_ PGGYS 4351_ CACPQ 4356_ GSSFI 4361_ EGSTT 4366_ ECDAA 4371_ IELPI 4376_ NLPPP 4381_ CRCMH 4386_ GGNCY 4391_ FDETD 4396_ LPKCK 4401_ CPSGY 4406_ TGKYC 4411_ EMAFS 4416_ KGISP 4421_ GTTAV 4426_ AVLLT 4431_ ILLIV 4436_ VIGAL 4441_ AIAGF 4446_ FHYRR 4451_ TGSLL 4456_ PALPK 4461_ LPSLS 4466_ SLVKP 4471_ SENGN 4476_ GVTFR 4481_ SGADL 4486_ NMDIG 4491_ VSGFG 4496_ PETAI 4501_ DRSMA 4506_ MSEDF 4511_ VMEMG 4516_ KQPII 4521_ FENPM 4526_ YSARD 4531_ SAVKV 4536_ VQPIQ 4541_ VTVSE 4546_ NVDNK 4551_ NYGSP 4556_ INPSE 4561_ IVPET 4566_ NPTSP 4571_ AADGT 4576_ QVTKW 4581_ NLFKR 4586_ KSKQT 4591_ TNFEN 4596_ PIYAQ 4601_ MENEQ 4606_ KESVA 4611_ ATPPP 4616_ SPSLP 4621_ AKPKP 4626_ PSRRD 4631_ PTPTY 4636_ SATED 4641_ TFKDT 4646_ANLVK
1: Multiligand endocytic receptor (By similarity). Acts together with CUBN to mediate endocytosis of high-density lipoproteins (By similarity). Mediates receptor-mediated uptake of polybasic drugs such as aprotinin, aminoglycosides and polymyxin B (By similarity). In the kidney, mediates the tubular uptake and clearance of leptin (By similarity). Also mediates transport of leptin across the blood-brain barrier through endocytosis at the choroid plexus epithelium (By similarity). Endocytosis of leptin in neuronal cells is required for hypothalamic leptin signaling and leptin-mediated regulation of feeding and body weight (By similarity). Mediates endocytosis and subsequent lysosomal degradation of CST3 in kidney proximal tubule cells (By similarity). Mediates renal uptake of 25-hydroxyvitamin D3 in complex with the vitamin D3 transporter GC/DBP (By similarity). Mediates renal uptake of metallothionein-bound heavy metals (PubMed:15126248). Together with CUBN, mediates renal reabsorption of myoglobin (By similarity). Mediates renal uptake and subsequent lysosomal degradation of APOM (By similarity). Plays a role in kidney selenium homeostasis by mediating renal endocytosis of selenoprotein SEPP1 (By similarity). Mediates renal uptake of the antiapoptotic protein BIRC5/survivin which may be important for functional integrity of the kidney (PubMed:23825075). Mediates renal uptake of matrix metalloproteinase MMP2 in complex with metalloproteinase inhibitor TIMP1 (By similarity). Mediates endocytosis of Sonic hedgehog protein N-product (ShhN), the active product of SHH (By similarity). Also mediates ShhN transcytosis (By similarity). In the embryonic neuroepithelium, mediates endocytic uptake and degradation of BMP4, is required for correct SHH localization in the ventral neural tube and plays a role in patterning of the ventral telencephalon (By similarity). Required at the onset of neurulation to sequester SHH on the apical surface of neuroepithelial cells of the rostral diencephalon ventral midline and to control PTCH1-dependent uptake and intracellular trafficking of SHH (By similarity). During neurulation, required in neuroepithelial cells for uptake of folate bound to the folate receptor FOLR1 which is necessary for neural tube closure (By similarity). In the adult brain, negatively regulates BMP signaling in the subependymal zone which enables neurogenesis to proceed (By similarity). In astrocytes, mediates endocytosis of ALB which is required for the synthesis of the neurotrophic factor oleic acid (By similarity). Involved in neurite branching (By similarity). During optic nerve development, required for SHH-mediated migration and proliferation of oligodendrocyte precursor cells (By similarity). Mediates endocytic uptake and clearance of SHH in the retinal margin which protects retinal progenitor cells from mitogenic stimuli and keeps them quiescent (By similarity). Plays a role in reproductive organ development by mediating uptake in reproductive tissues of androgen and estrogen bound to the sex hormone binding protein SHBG (By similarity). Mediates endocytosis of angiotensin-2 (By similarity). Also mediates endocytosis of angiotensis 1-7 (By similarity). Binds to the complex composed of beta-amyloid protein 40 and CLU/APOJ and mediates its endocytosis and lysosomal degradation (By similarity). Required for embryonic heart development (By similarity). Required for normal hearing, possibly through interaction with estrogen in the inner ear (By similarity)