Forkhead box protein O4 (Fork head domain transcription factor AFX1)
1_MDPGN 6_ ENSAT 11_ EAAAI 16_ IDLDP 21_ DFEPQ 26_ SRPRS 31_ CTWPL 36_ PRPEI 41_ ANQPS 46_ EPPEV 51_ EPDLG 56_ EKVHT 61_ EGRSE 66_ PILLP 71_ SRLPE 76_ PAGGP 81_ QPGIL 86_ GAVTG 91_ PRKGG 96_ SRRNA 101_ WGNQS 106_ YAELI 111_ SQAIE 116_ SAPEK 121_ RLTLA 126_ QIYEW 131_ MVRTV 136_ PYFKD 141_ KGDSN 146_ SSAGW 151_ KNSIR 156_ HNLSL 161_ HSKFI 166_ KVHNE 171_ ATGKS 176_ SWWML 181_ NPEGG 186_ KSGKA 191_ PRRRA 196_ ASMDS 201_ SSKLL 206_ RGRSK 211_ APKKK 216_ PSVLP 221_ APPEG 226_ ATPTS 231_ PVGHF 236_ AKWSG 241_ SPCSR 246_ NREEA 251_ DMWTT 256_ FRPRS 261_ SSNAS 266_ SVSTR 271_ LSPLR 276_ PESEV 281_ LAEEI 286_ PASVS 291_ SYAGG 296_ VPPTL 301_ NEGLE 306_ LLDGL 311_ NLTSS 316_ HSLLS 321_ RSGLS 326_ GFSLQ 331_ HPGVT 336_ GPLHT 341_ YSSSL 346_ FSPAE 351_ GPLSA 356_ GEGCF 361_ SSSQA 366_ LEALL 371_ TSDTP 376_ PPPAD 381_ VLMTQ 386_ VDPIL 391_ SQAPT 396_ LLLLG 401_ GLPSS 406_ SKLAT 411_ GVGLC 416_ PKPLE 421_ APGPS 426_ SLVPT 431_ LSMIA 436_ PPPVM 441_ ASAPI 446_ PKALG 451_ TPVLT 456_ PPTEA 461_ ASQDR 466_ MPQDL 471_ DLDMY 476_ MENLE 481_ CDMDN 486_ IISDL 491_ MDEGE 496_GLDFN
1: Transcription factor involved in the regulation of the insulin signaling pathway. Binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. Down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. Also involved in negative regulation of the cell cycle. Involved in increased proteasome activity in embryonic stem cells (ESCs) by activating expression of PSMD11 in ESCs, leading to enhanced assembly of the 26S proteasome, followed by higher proteasome activity