Calcium-transporting ATPase type 2C member 1 (ATPase 2C1) (EC 7.2.2.10) (ATP-dependent Ca(2+) pump PMR1) (Ca(2+)/Mn(2+)-ATPase 2C1) (Secretory pathway Ca(2+)-transporting ATPase type 1) (SPCA1)
1_MKVAR 6_ FQKIP 11_ NGENE 16_ TMIPV 21_ LTSKK 26_ ASELP 31_ VSEVA 36_ SILQA 41_ DLQNG 46_ LNKCE 51_ VSHRR 56_ AFHGW 61_ NEFDI 66_ SEDEP 71_ LWKKY 76_ ISQFK 81_ NPLIM 86_ LLLAS 91_ AVISV 96_ LMHQF 101_ DDAVS 106_ ITVAI 111_ LIVVT 116_ VAFVQ 121_ EYRSE 126_ KSLEE 131_ LSKLV 136_ PPECH 141_ CVREG 146_ KLEHT 151_ LARDL 156_ VPGDT 161_ VCLSV 166_ GDRVP 171_ ADLRL 176_ FEAVD 181_ LSIDE 186_ SSLTG 191_ ETTPC 196_ SKVTA 201_ PQPAA 206_ TNGDL 211_ ASRSN 216_ IAFMG 221_ TLVRC 226_ GKAKG 231_ VVIGT 236_ GENSE 241_ FGEVF 246_ KMMQA 251_ EEAPK 256_ TPLQK 261_ SMDLL 266_ GKQLS 271_ FYSFG 276_ IIGII 281_ MLVGW 286_ LLGKD 291_ ILEMF 296_ TISVS 301_ LAVAA 306_ IPEGL 311_ PIVVT 316_ VTLAL 321_ GVMRM 326_ VKKRA 331_ IVKKL 336_ PIVET 341_ LGCCN 346_ VICSD 351_ KTGTL 356_ TKNEM 361_ TVTHI 366_ FTSDG 371_ LHAEV 376_ TGVGY 381_ NQFGE 386_ VIVDG 391_ DVVHG 396_ FYNPA 401_ VSRIV 406_ EAGCV 411_ CNDAV 416_ IRNNT 421_ LMGKP 426_ TEGAL 431_ IALAM 436_ KMGLD 441_ GLQQD 446_ YIRKA 451_ EYPFS 456_ SEQKW 461_ MAVKC 466_ VHRTQ 471_ QDRPE 476_ ICFMK 481_ GAYEQ 486_ VIKYC 491_ TTYQS 496_ KGQTL 501_ TLTQQ 506_ QRDVY 511_ QQEKA 516_ RMGSA 521_ GLRVL 526_ ALASG 531_ PELGQ 536_ LTFLG 541_ LVGII 546_ DPPRT 551_ GVKEA 556_ VTTLI 561_ ASGVS 566_ IKMIT 571_ GDSQE 576_ TAVAI 581_ ASRLG 586_ LYSKT 591_ SQSVS 596_ GEEID 601_ AMDVQ 606_ QLSQI 611_ VPKVA 616_ VFYRA 621_ SPRHK 626_ MKIIK 631_ SLQKN 636_ GSVVA 641_ MTGDG 646_ VNDAV 651_ ALKAA 656_ DIGVA 661_ MGQTG 666_ TDVCK 671_ EAADM 676_ ILVDD 681_ DFQTI 686_ MSAIE 691_ EGKGI 696_ YNNIK 701_ NFVRF 706_ QLSTS 711_ IAALT 716_ LISLA 721_ TLMNF 726_ PNPLN 731_ AMQIL 736_ WINII 741_ MDGPP 746_ AQSLG 751_ VEPVD 756_ KDVIR 761_ KPPRN 766_ WKDSI 771_ LTKNL 776_ ILKIL 781_ VSSII 786_ IVCGT 791_ LFVFW 796_ RELRD 801_ NVITP 806_ RDTTM 811_ TFTCF 816_ VFFDM 821_ FNALS 826_ SRSQT 831_ KSVFE 836_ IGLCS 841_ NRMFC 846_ YAVLG 851_ SIMGQ 856_ LLVIY 861_ FPPLQ 866_ KVFQT 871_ ESLSI 876_ LDLLF 881_ LLGLT 886_ SSVCI 891_ VAEII 896_ KKVER 901_ SREKI 906_ QKHVS 911_STSSS
1: ATP-driven pump that supplies the Golgi apparatus with Ca(2+) and Mn(2+) ions, both essential cofactors for processing and trafficking of newly synthesized proteins in the secretory pathway (PubMed:12707275, PubMed:16192278, PubMed:20439740, PubMed:21187401, PubMed:30923126). Within a catalytic cycle, acquires Ca(2+) or Mn(2+) ions on the cytoplasmic side of the membrane and delivers them to the lumenal side. The transfer of ions across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing to outward-facing state (PubMed:16192278, PubMed:16332677, PubMed:30923126). Plays a primary role in the maintenance of Ca(2+) homeostasis in the trans-Golgi compartment with a functional impact on Golgi and post-Golgi protein sorting as well as a structural impact on cisternae morphology (PubMed:14632183, PubMed:20439740). Responsible for loading the Golgi stores with Ca(2+) ions in keratinocytes, contributing to keratinocyte differentiation and epidermis integrity (PubMed:10615129, PubMed:14632183, PubMed:20439740). Participates in Ca(2+) and Mn(2+) ions uptake into the Golgi store of hippocampal neurons and regulates protein trafficking required for neural polarity (By similarity). May also play a role in the maintenance of Ca(2+) and Mn(2+) homeostasis and signaling in the cytosol while preventing cytotoxicity (PubMed:21187401)