Phospholipid-transporting ATPase IH (EC 7.6.2.1) (ATPase IS) (ATPase class VI type 11A) (P4-ATPase flippase complex alpha subunit ATP11A)
1_MDCSL 6_ VRTLV 11_ HRYCA 16_ GEENW 21_ VDSRT 26_ IYVGH 31_ REPPP 36_ GAEAY 41_ IPQRY 46_ PDNRI 51_ VSSKY 56_ TFWNF 61_ IPKNL 66_ FEQFR 71_ RVANF 76_ YFLII 81_ FLVQL 86_ IIDTP 91_ TSPVT 96_ SGLPL 101_ FFVIT 106_ VTAIK 111_ QGYED 116_ WLRHK 121_ ADNAM 126_ NQCPV 131_ HFIQH 136_ GKLVR 141_ KQSRK 146_ LRVGD 151_ IVMVK 156_ EDETF 161_ PCDLI 166_ FLSSN 171_ RGDGT 176_ CHVTT 181_ ASLDG 186_ ESSHK 191_ THYAV 196_ QDTKG 201_ FHTEE 206_ DIGGL 211_ HATIE 216_ CEQPQ 221_ PDLYK 226_ FVGRI 231_ NVYSD 236_ LNDPV 241_ VRPLG 246_ SENLL 251_ LRGAT 256_ LKNTE 261_ KIFGV 266_ AIYTG 271_ METKM 276_ ALNYQ 281_ SKSQK 286_ RSAVE 291_ KSMNA 296_ FLIVY 301_ LCILI 306_ SKALI 311_ NTVLK 316_ YMWQS 321_ EPFRD 326_ EPWYN 331_ QKTES 336_ ERQRN 341_ LFLKA 346_ FTDFL 351_ AFMVL 356_ FNYII 361_ PVSMY 366_ VTVEM 371_ QKFLG 376_ SYFIT 381_ WDEDM 386_ FDEET 391_ GEGPL 396_ VNTSD 401_ LNEEL 406_ GQVEY 411_ IFTDK 416_ TGTLT 421_ ENNME 426_ FKECC 431_ IEGHV 436_ YVPHV 441_ ICNGQ 446_ VLPES 451_ SGIDM 456_ IDSSP 461_ SVNGR 466_ EREEL 471_ FFRAL 476_ CLCHT 481_ VQVKD 486_ DDSVD 491_ GPRKS 496_ PDGGK 501_ SCVYI 506_ SSSPD 511_ EVALV 516_ EGVQR 521_ LGFTY 526_ LRLKD 531_ NYMEI 536_ LNREN 541_ HIERF 546_ ELLEI 551_ LSFDS 556_ VRRRM 561_ SVIVK 566_ SATGE 571_ IYLFC 576_ KGADS 581_ SIFPR 586_ VIEGK 591_ VDQIR 596_ ARVER 601_ NAVEG 606_ LRTLC 611_ VAYKR 616_ LIQEE 621_ YEGIC 626_ KLLQA 631_ AKVAL 636_ QDREK 641_ KLAEA 646_ YEQIE 651_ KDLTL 656_ LGATA 661_ VEDRL 666_ QEKAA 671_ DTIEA 676_ LQKAG 681_ IKVWV 686_ LTGDK 691_ METAA 696_ ATCYA 701_ CKLFR 706_ RNTQL 711_ LELTT 716_ KRIEE 721_ QSLHD 726_ VLFEL 731_ SKTVL 736_ RHSGS 741_ LTRDN 746_ LSGLS 751_ ADMQD 756_ YGLII 761_ DGAAL 766_ SLIMK 771_ PREDG 776_ SSGNY 781_ RELFL 786_ EICRS 791_ CSAVL 796_ CCRMA 801_ PLQKA 806_ QIVKL 811_ IKFSK 816_ EHPIT 821_ LAIGD 826_ GANDV 831_ SMILE 836_ AHVGI 841_ GVIGK 846_ EGRQA 851_ ARNSD 856_ YAIPK 861_ FKHLK 866_ KMLLV 871_ HGHFY 876_ YIRIS 881_ ELVQY 886_ FFYKN 891_ VCFIF 896_ PQFLY 901_ QFFCG 906_ FSQQT 911_ LYDTA 916_ YLTLY 921_ NISFT 926_ SLPIL 931_ LYSLM 936_ EQHVG 941_ IDVLK 946_ RDPTL 951_ YRDVA 956_ KNALL 961_ RWRVF 966_ IYWTL 971_ LGLFD 976_ ALVFF 981_ FGAYF 986_ VFENT 991_ TVTSN 996_ GQIFG 1001_ NWTFG 1006_ TLVFT 1011_ VMVFT 1016_ VTLKL 1021_ ALDTH 1026_ YWTWI 1031_ NHFVI 1036_ WGSLL 1041_ FYVVF 1046_ SLLWG 1051_ GVIWP 1056_ FLNYQ 1061_ RMYYV 1066_ FIQML 1071_ SSGPA 1076_ WLAIV 1081_ LLVTI 1086_ SLLPD 1091_ VLKKV 1096_ LCRQL 1101_ WPTAT 1106_ ERVQT 1111_ KSQCL 1116_ SVEQS 1121_ TIFML 1126_SQTSS
1: Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids, phosphatidylserines (PS) and phosphatidylethanolamines (PE), from the outer to the inner leaflet of the plasma membrane (PubMed:25315773, PubMed:25947375, PubMed:26567335, PubMed:29799007, PubMed:30018401, PubMed:36300302). Does not show flippase activity toward phosphatidylcholine (PC) (PubMed:34403372). Contributes to the maintenance of membrane lipid asymmetry with a specific role in morphogenesis of muscle cells. In myoblasts, mediates PS enrichment at the inner leaflet of plasma membrane, triggering PIEZO1-dependent Ca2+ influx and Rho GTPases signal transduction, subsequently leading to the assembly of cortical actomyosin fibers and myotube formation (PubMed:29799007). May be involved in the uptake of farnesyltransferase inhibitor drugs, such as lonafarnib