Transcription factor A, mitochondrial (mtTFA) (Mitochondrial transcription factor 1) (MtTF1) (Transcription factor 6) (TCF-6) (Transcription factor 6-like 2)
1_MAFLR 6_ SMWGV 11_ LSALG 16_ RSGAE 21_ LCTGC 26_ GSRLR 31_ SPFSF 36_ VYLPR 41_ WFSSV 46_ LASCP 51_ KKPVS 56_ SYLRF 61_ SKEQL 66_ PIFKA 71_ QNPDA 76_ KTTEL 81_ IRRIA 86_ QRWRE 91_ LPDSK 96_ KKIYQ 101_ DAYRA 106_ EWQVY 111_ KEEIS 116_ RFKEQ 121_ LTPSQ 126_ IMSLE 131_ KEIMD 136_ KHLKR 141_ KAMTK 146_ KKELT 151_ LLGKP 156_ KRPRS 161_ AYNVY 166_ VAERF 171_ QEAKG 176_ DSPQE 181_ KLKTV 186_ KENWK 191_ NLSDS 196_ EKELY 201_ IQHAK 206_ EDETR 211_ YHNEM 216_ KSWEE 221_ QMIEV 226_ GRKDL 231_ LRRTI 236_ KKQRK 241_YGAEE
1: Binds to the mitochondrial light strand promoter and functions in mitochondrial transcription regulation (PubMed:29445193, PubMed:32183942). Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA (PubMed:29149603). In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand (PubMed:20410300). Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase (PubMed:22037172). Promotes transcription initiation from the HSP1 and the light strand promoter by binding immediately upstream of transcriptional start sites (PubMed:22037172). Is able to unwind DNA (PubMed:22037172). Bends the mitochondrial light strand promoter DNA into a U-turn shape via its HMG boxes (PubMed:1737790). Required for maintenance of normal levels of mitochondrial DNA (PubMed:19304746, PubMed:22841477). May play a role in organizing and compacting mitochondrial DNA (PubMed:22037171)