Cyclin-dependent kinase 3 (EC 2.7.11.22) (Cell division protein kinase 3)
1_MDMFQ 6_ KVEKI 11_ GEGTY 16_ GVVYK 21_ AKNRE 26_ TGQLV 31_ ALKKI 36_ RLDLE 41_ MEGVP 46_ STAIR 51_ EISLL 56_ KELKH 61_ PNIVR 66_ LLDVV 71_ HNERK 76_ LYLVF 81_ EFLSQ 86_ DLKKY 91_ MDSTP 96_ GSELP 101_ LHLIK 106_ SYLFQ 111_ LLQGV 116_ SFCHS 121_ HRVIH 126_ RDLKP 131_ QNLLI 136_ NELGA 141_ IKLAD 146_ FGLAR 151_ AFGVP 156_ LRTYT 161_ HEVVT 166_ LWYRA 171_ PEILL 176_ GSKFY 181_ TTAVD 186_ IWSIG 191_ CIFAE 196_ MVTRK 201_ ALFPG 206_ DSEID 211_ QLFRI 216_ FRMLG 221_ TPSED 226_ TWPGV 231_ TQLPD 236_ YKGSF 241_ PKWTR 246_ KGLEE 251_ IVPNL 256_ EPEGR 261_ DLLMQ 266_ LLQYD 271_ PSQRI 276_ TAKTA 281_ LAHPY 286_ FSSPE 291_ PSPAA 296_RQYVL
1: Serine/threonine-protein kinase that plays a critical role in the control of the eukaryotic cell cycle; involved in G0-G1 and G1-S cell cycle transitions. Interacts with CCNC/cyclin-C during interphase. Phosphorylates histone H1, ATF1, RB1 and CABLES1. ATF1 phosphorylation triggers ATF1 transactivation and transcriptional activities, and promotes cell proliferation and transformation. CDK3/cyclin-C mediated RB1 phosphorylation is required for G0-G1 transition. Promotes G1-S transition probably by contributing to the activation of E2F1, E2F2 and E2F3 in a RB1-independent manner