Cyclin-dependent kinase 6 (EC 2.7.11.22) (Cell division protein kinase 6) (Serine/threonine-protein kinase PLSTIRE)
1_MEKDG 6_ LCRAD 11_ QQYEC 16_ VAEIG 21_ EGAYG 26_ KVFKA 31_ RDLKN 36_ GGRFV 41_ ALKRV 46_ RVQTG 51_ EEGMP 56_ LSTIR 61_ EVAVL 66_ RHLET 71_ FEHPN 76_ VVRLF 81_ DVCTV 86_ SRTDR 91_ ETKLT 96_ LVFEH 101_ VDQDL 106_ TTYLD 111_ KVPEP 116_ GVPTE 121_ TIKDM 126_ MFQLL 131_ RGLDF 136_ LHSHR 141_ VVHRD 146_ LKPQN 151_ ILVTS 156_ SGQIK 161_ LADFG 166_ LARIY 171_ SFQMA 176_ LTSVV 181_ VTLWY 186_ RAPEV 191_ LLQSS 196_ YATPV 201_ DLWSV 206_ GCIFA 211_ EMFRR 216_ KPLFR 221_ GSSDV 226_ DQLGK 231_ ILDVI 236_ GLPGE 241_ EDWPR 246_ DVALP 251_ RQAFH 256_ SKSAQ 261_ PIEKF 266_ VTDID 271_ ELGKD 276_ LLLKC 281_ LTFNP 286_ AKRIS 291_ AYSAL 296_ SHPYF 301_ QDLER 306_ CKENL 311_ DSHLP 316_ PSQNT 321_SELNT
1: Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation; promotes G1/S transition. Phosphorylates pRB/RB1 and NPM1. Interacts with D-type G1 cyclins during interphase at G1 to form a pRB/RB1 kinase and controls the entrance into the cell cycle. Involved in initiation and maintenance of cell cycle exit during cell differentiation; prevents cell proliferation and negatively regulates cell differentiation, but is required for the proliferation of specific cell types (e.g. erythroid and hematopoietic cells). Essential for cell proliferation within the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricles. Required during thymocyte development. Promotes the production of newborn neurons, probably by modulating G1 length. Promotes, at least in astrocytes, changes in patterns of gene expression, changes in the actin cytoskeleton including loss of stress fibers, and enhanced motility during cell differentiation. Prevents myeloid differentiation by interfering with RUNX1 and reducing its transcription transactivation activity, but promotes proliferation of normal myeloid progenitors. Delays senescence. Promotes the proliferation of beta-cells in pancreatic islets of Langerhans. May play a role in the centrosome organization during the cell cycle phases (PubMed:23918663)