Norrin (Norrie disease protein) (X-linked exudative vitreoretinopathy 2 protein)
1_MRKHV 6_ LAASF 11_ SMLSL 16_ LVIMG 21_ DTDSK 26_ TDSSF 31_ IMDSD 36_ PRRCM 41_ RHHYV 46_ DSISH 51_ PLYKC 56_ SSKMV 61_ LLARC 66_ EGHCS 71_ QASRS 76_ EPLVS 81_ FSTVL 86_ KQPFR 91_ SSCHC 96_ CRPQT 101_ SKLKA 106_ LRLRC 111_ SGGMR 116_ LTATY 121_ RYILS 126_CHCEE
1: Activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. Plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. Acts in concert with TSPAN12 to activate FZD4 independently of the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1). May be involved in a pathway that regulates neural cell differentiation and proliferation. Possible role in neuroectodermal cell-cell interaction